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Biomedical subjects

AK Chakraborty

Publications and source records attributed to AK Chakraborty.

5 recordsLinked to original sources
PubMed1998

Interaction of Mixed Surfactants with Bacterial Lipopolysaccharide.

The interaction of lipopolysaccharide isolated from Klebsiella O3 strain with cationic and cationic-nonionic mixed surfactants has been studied by turbidimetry and by spectrophotometric, spectrofluorometric, viscosity, and conductance measurements. The cationic surfactants benzyldimethyl-n-hexadecylammonium chloride (BDHAC), cetyltrimethylammonium bromide (CTAB), cetylpyridinium chloride (CpCl), dodecylpyridinium chloride (DpCl), and nonionic surfactants polyoxyethylene glycol-tert-octylphenyl ether (Triton X-100), polyoxyethylenesorbitan monolaurate (Tween-20), and polyoxyethylene (23) lauryl ether (Brij-35) were used in all the experiments as single surfactants and also as mixed surfactants of different compositions. Mixed surfactants were found to be more effective in binding with the lipopolysaccharide molecules. Micellar effects of cationic and cationic-nonionic mixed surfactants on binding with the anionic polymer are presented in this paper. The binding was found to be electrostatic in origin and also hydrophobic in nature to a certain extent. Copyright 1998 Academic Press.

Journal Article↗
PubMed1998

Metabolic Study of Isoproturon in Goats Following a Single Oral Administration: Toxicokinetics and Recovery.

Toxicokinetic behavior and recoveries of isoproturon from feces, urine, and different tissues of goat were determined after 4, 5, 6, and 7 days following single oral administration at 500 mg/kg. Isoproturon was rapidly absorbed and attained blood concentration within 15 min of administration. The kinetic behavior followed a two-compartment open model. The higher t(1/2)(beta) (9.78 +/- 0.33 h) and V(d)()area (4.49 +/- 0.41 L/kg) associated with lower Cl(B) (0.32 +/- 0.02 L/kg/h) suggested slow elimination from the blood. Approximately 56% of the total administered compound was recovered from feces. The rate of excretion of isoproturon through feces was maximum at 48 h and could not be detected beyond 120 h. The excretion pattern of isoproturon through urine resembled that of feces, and approximately 10-11% was eliminated in urine. A maximum quantity of residue was detected in all tissues of goats slaughtered after 4 days followed by a substantial decline after day 5, and nothing could be detected after day 7. Histopathological study revealed that isoproturon produced moderate cellular changes like fatty degeneration in the liver and kidney and emphysema in the lung after 7 days post administration.

Journal Article↗