Biomedical subjects

AJ McKane

Publications and source records attributed to AJ McKane.

14 recordsLinked to original sources

PubMed2000

Resonances while surmounting a fluctuating barrier

Electronic analog experiments on escape over a fluctuating potential barrier are performed for the case when the fluctuations are caused by Ornstein-Uhlenbeck noise (OUN). In its dependence on the relation between the two OUN parameters (the correlation time tau and noise strength Q) the nonmonotonic variation of the mean escape time T as a function of tau can exhibit either a minimum (resonant activation), or a maximum (inhibition of activation), or both these effects. The possible resonant nature of these features is discussed. We claim that T is not a good quantity to describe the resonancelike character of the problem. Independently of the specific relation between the OUN parameters, the resonance manifests itself as a maximal lowering of the potential barrier during the escape event, and it appears for tau of the order of the relaxation time toward the metastable state.

Journal Article↗

PubMed2000

Ratchet driven by quasimonochromatic noise

The currents generated by noise-induced activation processes in a periodic potential are investigated analytically, by digital simulation and by performing analog experiments. The noise is taken to be quasimonochromatic and the potential to be a smoothed sawtooth. Two analytic approaches are studied. The first involves a perturbative expansion in inverse powers of the frequency characterizing quasimonochromatic noise and the second is a direct numerical integration of the deterministic differential equations obtained in the limit of weak noise. These results, together with the digital and analog experiments, show that the system does indeed give rise, in general, to a net transport of particles. All techniques also show that a current reversal exists for a particular value of the noise parameters.

Journal Article↗

PubMed1998

Modelling Coevolution in Multispecies Communities.

We introduce the Webworld model, which links together the ecological modelling of food web structure with the evolutionary modelling of speciation and extinction events. The model describes dynamics of ecological communities on an evolutionary time-scale. Species are defined as sets of characteristic features, and these features are used to determine interaction scores between species. A simple rule is used to transfer resources from the external environment through the food web to each of the species, and to determine mean population sizes. A time step in the model represents a speciation event. A new species is added with features similar to those of one of the existing species and a new food web structure is than calculated. The new species may (i) add stably to the web, (ii) become extinct immediately because it is poorly adapted, or (iii) cause one or more other species to become extinct due to competition for resources. We measure various properties of the model webs and compare these with data on real food webs. These properties include the proportions of basal, intermediate and top species, the number of links per species and the number of trophic levels. We also study the evolutionary dynamics of the model ecosystem by following the fluctuations in the total number of species in the web. Extinction avalanches occur when novel organisms arise which are significantly better adapted than existing ones. We discuss these results in relation to the observed extinction events in the fossil record, and to the theory of self-organized criticality.Copyright 1998 Academic Press

Journal Article↗

PubMed1995