Search PubMed⌕ Search

Biomedical subjects

A des Lauriers

Publications and source records attributed to A des Lauriers.

At least 19 recordsLinked to original sources
PubMed1992

Clinical subtypes and age at onset in schizophrenic siblings.

This study examines the concordance of clinical subtypes and age at onset of schizophrenia in 42 sibships of multiply affected schizophrenic patients. Subtypes were defined by four major diagnostic systems (DSM-III, DSM-III-R, ICD-10, and Tsuang-Winokur criteria) and rated both for the first hospitalization and long-term diagnosis. When a sibship method was used, no concordance for subtypes was found in siblings. Age at onset, analyzed as a continuous variable with the intraclass correlation method, was found to be correlated in siblings. This finding suggest that the search for continuous traits distributed in families of schizophrenic patients might constitute an alternative to discrete category-based family studies.

Age Factors↗
PubMed1983

[Plasma levels of desmethylclomipramine and clomipramine at steady-state in the morning. Correlative analysis and prediction of theoretical blood clomipramine].

Clomipramine (CMI) was administered to eight patients, either as an antidepressive drug or, in two patients, as an antalgic drug (average age: 54 y.; average body surface area: 1,71 m2). These patients were treated with 20 to 150 mg, every day, for various lengths of time: min.; one week: max.; 7 years, till the day before the determination of plasma levels. The samples were drawn on patients, fasting, in the morning. Plasma levels of CMI, Desmethylclomipramine (DCMI) and Cortisol were dosed by means of High Performance Liquid Chromatography with U. V. detection.

Adult↗
PubMed1982

[Drug combinations in the treatment of depression].

Four types of combination therapy may be used in the treatment of depression: anxiolytics and antidepressants, neuroleptics and antidepressants, co-administration of two or more antidepressants, association of antidepressants with drugs correcting antidepressant-induced side-effects. First, the pros and cons of these combinations are described as they appear in daily practice. In the second part, the theoretical reasons for supporting or contraindicating such combinations are discussed in the light of pharmacological data. The value of recent molecules such as nomifensin, viloxazin, amineptin and mianserin which interact with a minimum number of neurotransmitters is stressed.

Antidepressive Agents↗
PubMed1982

[Psychiatric emergencies and family crisis. A possible systemic approach at a general hospital].

Psychiatric emergencies concern not only sectorized psychiatric organizations but general hospitals as well, especially in large cities. No set-ups for long-term management are available in general hospitals and means for short-term intermittent action should be evolved. Family crisis may be responsible for psychiatric emergencies as they may lead to decompensation due to the breaking-up of familial relationships. When confronted with such situations, practitioners must of course face the emergency by using various specific chemotherapeutic agents or by hospitalizing the patient. However, practitioners should also concern themselves with acting upon the whole family in order to help them to develop solutions to the crisis. The modalities of this global approach of psychiatric disorders are delineated in the family crisis therapeutic technique.

Conflict, Psychological↗
PubMed1982

[Lithium and diabetes insipidus. Theoretical and practical aspects. Therapeutic value of thiazide diuretics (author's transl)].

Lithium is increasingly prescribed by psychiatrists for manic-depressive psychosis and other affective disorders. Therefore, psychiatrists should be familiar with lithium-induced nephrogenic diabetes insipidus. Management of this condition is discussed. Thiazide diuretics have a paradoxical antidiuretic effect in lithium-induced diabetes insipidus. For this reason, it is no longer warranted to contraindicate concomitant use of lithium and thiazide diuretics.

Adult↗