Search PubMed⌕ Search

Biomedical subjects

A Zubizarreta

Publications and source records attributed to A Zubizarreta.

At least 73 records · Page 4Linked to original sources
PubMed1979

Acute lymphatic leukemia with mediastinal involvement.

Mediastinal involvement was found in 11 (group A) of 43 patients affected with acute lymphatic leukemia when early thoracic roentgenograms of these patients were reviewed. Several clinicobiological characteristics of these patients were compared with those with a normal mediastinum as shown in their roentgenograms (group B). Statistically significant differences were observed between group A and group B not only as far as age was concerned (13 years group A, 7.4 years group B) but also in the ratio males/females (10:1 group A, 10:20 group B) and with regard to the leukocyte counts (266 x 10(9)/liter group A, 20 x 10(9)/liter group B). In addition, patients from group A showed a greater 'tumoral mass' and a more prominent extrahematological involvement (45% group A, 15% group B). In these cases 'convoluted' cells were frequently discovered and the blastic cells exhibited significantly lower scores of PAS-positivity and more marked acid phosphatase activity than those in group B. Although the rate of complete remissions (CR) obtained in both groups was similar (80% group A, 93% group B), marked differences were observed not only in the duration of CR but in the period of survival after CR as well, both factors being more prolonged in group B patients. 50% of patients with mediastinal involvement (group A) relapsed in the first 6 months of the evolution of the disease.

Adolescent↗
PubMedDate not supplied

[Immunoglobulin levels at different ages in the healthy child population].

In this study, we report the IgE, IgA, IgM and IgG levels in the serum and the secretory IgA obtained from a group of children of different ages with normal morphgram, with no personal or family history of allergies and without recurrent infectious diseases. The IgG, IgA and IgM and salivary secretory IgA were determined by the immunonephelometry technique, using specific anti-serum for heavy chains obtained form rabbits and purified by affinitive chromatography. The IgE was determined by radioimmunoassay, using the PRIST technique. If we look at all published works about normal levels of immunoglobulins in serum, we can see many differences among the results obtained by different authors. Our results are different as well; however, there is no difference in IgE levels. In our work, the secretory IgA level cannot be compared as we do not have any other study available for comparison. We think that our results differ from those obtained by other authors because of differences in laboratory and statistical techniques and other factors such as environment, constitution, nutrition, etc.

Age Factors↗