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Biomedical subjects

A Zlotnick

Publications and source records attributed to A Zlotnick.

At least 55 records · Page 3Linked to original sources
PubMed1981

Immunological evaluation of asymptomatic carriers of hepatitis B virus.

The immune system of 69 asymptomatic HBsAg carriers with normal liver function tests was evaluated. B cell function, as documented by serum immunoglobulin levels, number of mouse rosette-forming lymphocytes and lymphocyte reactivity to staphylococcal protein A, was intact. On the other hand, T cell function was markedly impaired. This was manifested by a significant decrease in E rosette-forming lymphocytes, an increase in stable rosette-forming cells and decreased reactivity to phytohaemagglutinin and concanavalin A. These data rule out the possibility that the immunological aberrations associated with hepatitis B infection are secondary to liver injury. The abnormal immune state either precedes the viral infection, thus predisposing to the acquisition of a carrier state or, alternatively, is a direct result of the infection.

Adult↗
PubMed1980

Coexistence of a circulating IgG-albumin complex and a gamma heavy chain in the same patient.

A patient with an IgG-albumin complex and a gamma heavy chain in his serum was studied by crossed immunoelectrophoresis. The IgG-albumin complex was not dissociated after incubation with 2-mercaptoethanol but it was after incubation with sodium dodecyl sulfate. Evidence was obtained that the IgG and albumin were held together by noncovalent bonds, possibly due to an antigen-antibody reaction.

Antigen-Antibody Complex↗
PubMed1980

Epidemiology of polymyositis-dermatomyositis in Israel, 1960-76.

We attempted to identify all cases with polymyositis and/or dermatomyositis (PM-DM) admitted to hospitals in Israel during 1960-76. The diagnosis of PM-DM was retrospectively confirmed in 86 Jewish patients. The age-adjusted incidence rates increased from 1.30 in 1960-64 to 2.57 in 1970-74, with an overall incidence of 2.18 new cases diagnosed annually per 10(6) population. The male:female ratio in this series was 0.59. Females predominated among patients younger than 60 years of age, while males and females aged 60 or more appeared to be equally affected. The age distribution was heterogeneous with modes in the second and seventh decades. The annual incidence of PM-DM increased from 0.47 cases per 10(6) persons in the third decade to a peak of 6.32 in the seventh. The incidence of childhood PM-DM among non-Western Jews(of African or Asian origin) was significantly higher than that among Western Jews (of European or American origin). On the other hand, the incidence of adult PM-DM among Western Jews exceeded that among Jews of non-Western extraction.

Adolescent↗
PubMed1978

Familial clustering and immune response in family contacts of patients with HBsAg-positive liver cirrhosis.

Families of 11 patients with hepatitis B surface antigen (HBsAg)-positive cirrhosis were studied to evaluate the immunologic correlates and extent of intrafamilial HBsAg clustering. Of 76 family contacts, 12 were identified to be asymptomatic carriers of HBsAg and two were diagnosed to have HSsAg-positive cirrhosis. The over-all HBsAg prevalence for the 76 contacts was 18% and that for all 87 members studied 29.0%. Serologic evidence of hepatitis B virus (HBV) infection (either HBsAg, anti-HBs, or both) was detected in 59% of all family members. HBsAg was more prevalent in males (47%) compared with females (16%), and anti-HBs was more prevalent in females (42%) compared with males (18%). Evidence of an immunologic response in clinically unaffected HBsAg-negative family contacts consisted of elevated serum IgG levels (mean 1660 mg/100 ml) and increased prevalence of anti-smooth muscle and antimitochondrial antibodies (16% and 6%, respectively). The prevalence of one or more autoantibodies in all HBsAg-negative family contacts was 20%, and it was higher in females (25%) than in males (13%). The present study demonstrates that HBsAg clustering occurs in families of patients with cirrhosis in the Jerusalem area and indicates that HBsAg-negative family contacts may have increased B-cell activity.

Adult↗
PubMed1977

Multiple myeloma terminating in lymphocytic leukemia with B-lymphocyte membrane markers.

The development of lymphocytic leukemia with a rapidly fatal clinical course is reported in a patient with kappa light-chain multiple myeloma treated with alkeran. The leukemic cells lacked the ultrastructural features of plasma cells but bore readily detectable B-cell markers and resembled lymphocytes under the light, transmission, and scanning electron microscopes. The leukemic phase is perhaps best defined as lymphocytic and probably represents a variant of plasma cell leukemia, in which the cells showed a degree of dedifferentiation from plasma cells to B lymphocytes. The possible relation between these 2 proliferative processes is discussed and the nature of leukemias developing in cases of plasma cell myeloma is briefly reviewed.

B-Lymphocytes↗
PubMed1977

Macroglobulinemia of Waldenström associated with severe osteolytic lesions.

Osteolytic lesions are not known to be associated with chronic lymphocytic leukemia and are rare in macroglobulinemia of Waldenström. In the present paper we report a patient suffering from macroglobulinemia associated with chronic lymphocytic leukemia in whom osteolytic lesions, resembling those of multiple myeloma were found. Treatment with chlorambucil resulted in normalization of the peripheral blood smear, but the malignant infiltration of the bone marrow continued and manifested itself by appearance of new osteolytic lesions, though some of the old lesions underwent recalcification after treatment.

Aged↗
PubMed1977

Pyridoxal-5-phosphate-resistant sideroblastic anaemia with trisomy 8 mosaicism in the bone marrow.

A patient with sideroblastic anaemia manifested a trisomic condition for chromosome number 8 in 75% of his bone marrow cells. Cytogenetic studies of peripheral lymphocytes demonstrated a normal male karyotype. The anaemia was resistant to treatment with pyridoxal-5-phosphate; this is in contradiction with the response achieved in some patients with the primary acquired form of sideroblastic anaemia.

Adult↗
PubMed1976

IgA deficiency and autoimmune hemolytic disease.

A case of familial selective IgA deficiency associated with autoimmune hemolytic disease is reported that illustrates the therapeutic implications when these two entities coexist. Immunoglobulin screening is recommended for patients with AHD who require blood transfusions, in order to identify IgA-deficient patients who may have anti-IgA anaphylactic reactions.

Adult↗
PubMed1975

Serum immunoglobulin levels in healthy adults of various ethnic groups in a rural family practice in Israel.

A study on the immunoglobulin levels of five ethnic groups in a rural population in Israel was carried out. The ethnic group comprised Yemenite, Cochin, Kurd, North African, and Ashkenazi Jews. Yemenites have a low level of IgA, Ashkenazis have a high IgM level, Cochins and North Africans have high levels of IgG and IgA, and Kurds show low IgM levels. Females have higher IgM levels than males. No positive correlation between immunoglobulin levels and age could be demonstrated. A connection between these levels and exogenous and endogenous factors in the various ethnic groups is discussed.

Adult↗
PubMed1975

Renal pathologic findings associated with monoclonal gammopathies.

The myeloma kidney is characterized by casts in the distal and collecting tubules. The glomeruli are hardly affected unless amyloidosis is present. When the glomeruli are involved, the proteinuria is nonselective and, in some cases, the whole paraprotein is excreted in the urine. Nephrocalcinosis may be present and focal myeloma cell infiltration in the interstitium is a characteristic, but inconstant, finding. The nephrotic syndrome is extremely rare; if it exists, amyloidosis should be suspected. In contrast to multiple myeloma, the glomeruli are frequently involved in macroglobulinemia of Waldenstrom. Hyaline intracapillary deposits consisting of pure IgM are a characteristic finding as is infiltration of the kidney with lymphoid cells. No characteristic lesion of the kidney has been described in the heavy-chain diseases. Mixed cryoglobulinemia associated with an IgM paraprotein can produce glomerulonephritis that is due to the deposition in the glomeruli of an immune complex consisting of IgG, IgM, and complement.

Animals↗