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Biomedical subjects

A Zimmermann

Publications and source records attributed to A Zimmermann.

At least 433 records · Page 24Linked to original sources
PubMed1976

[The application of Actihaemyl in chronically inflamed and dystrophic urinary bladder (author's transl)].

The effect of automated continuous irrigation treatment with Actihaemyl on bacterial growth in the infected urinary bladder was tested using an experimental model. The result was that instillation alone of this preparation promoted growth of Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa in the infected bladder. With simultaneous application of Framycetinsulfate or Kanamycin the growth of Pr. mirabilis and Ps. aeruginosa was totally suppressed in the "urine", and the growth of E. coli extensively low. At the same time there was a clear reduction in the bacterial count in the coagulum that served as a substitute bladder wall. Thus a urinary tract infection is a contraindication for local treatment with Actihaemyl of a tropically disturbed urinary bladder inasmuch as an effective antibiotic is not added to the instillate. With the latter combination, however, a therapeutic trial is justified in chronic, inflammatory, dystrophic bladders.

Actihaemyl↗
PubMed1976

Monoclonal plasma cell population in the uterus.

The case of a 28-year-old female patient is presented. Heavy infiltration with plasma cells of uterine tissue removed by surgical currettage following an aborted pregnancy was detected by cytological and histological examination. Subsequent immunohistochemical studies revealed the monoclonal nature of these cells: intracellular immunoglobulin contained gamma- and lambda-chains exclusively. Since careful clinical examination produced no evidence in favor of multiple myeloma, these findings were tentatively interpreted to be compatible with the diagnosis of solitary plasmocytoma of the uterus.

Abortion, Habitual↗
PubMed1975

[Immunological aspects of gastrointestinal neoplasms].

The mammalian immune system appears to play an essential role in preventing the development, and/or in controlling growth and spread, of malignant tumor cells. Antigenic properties of neoplastic cells and defense mechanism of the tumor host are briefly reviewed. The relative importance of immune reactions and other "non-specific" means of host defense with regard to tumor development and growth are discussed in the light of available experimental and clinical evidence. An attempt is made to incorporate these considerations into a hypothesis relating to the development of intestinal neoplasms.

Antigens, Neoplasm↗
PubMed1975

[Differentiation of urinary bacteria in urological practice].

The value of a new differential diagnostic nutrient medium was tested on 360 urines from urological patients. Simultaneously every urine specimen was examined according to classical bacteriological differential methods and colony counting. In 137 sterile urines there was agreement between the two methods in approximately 93%. On the basis of colony counting 96% of the 223 urinary tract infections could be diagnosed with the new test. Differentiation of the infecting organisms was possible in 71% of the infections.

Bacteriological Techniques↗
PubMedDate not supplied

The N-terminal propeptide of collagen type III in serum reflects activity and degree of fibrosis in patients with chronic liver disease.

To evaluate the diagnostic significance of the collagen Type III (Col 1-3) N-terminal propeptide of procollagen Type III, with respect to activity and degree of liver fibrosis, Col 1-3 serum concentrations were measured in 111 patients with chronic liver diseases and in 60 patients were correlated with liver histology and morphometry. Col 1-3 was measured by a specific radioimmunoassay. Biopsies were read without knowledge of diagnosis. Periportal and intralobular lesions were assessed semiquantitatively by allocating 1 of 4 severity grades to each parameter. All portal areas were measured morphometrically. Compared to 27 normal controls, Col 1-3 concentrations were significantly elevated in patients with untreated chronic active hepatitis, cirrhosis and primary biliary cirrhosis, but not in chronic persistent hepatitis or fatty liver. Morphometrically measured portal tract area significantly correlated with Col 1-3 plasma levels. Among the semiquantitatively measured periportal lesions, the number of fibroblasts exhibited the closest relationship with Col 1-3 levels; there was no relationship between Col 1-3 levels and intralobular lesions. These data suggest that Col 1-3 serum levels reliably reflect the activity and degree of liver fibrosis and are useful along with liver biopsy in follow-up of patients with chronic liver disease.

Adult↗