Endocrine function in multiple sclerosis possible correlation with immunitary phenomena.
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Biomedical subjects
Publications and source records attributed to A Zibetti.
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18 patients with severe stabilized pyramidal hypertonia were treated with Trazodone for a minimum period of 60 days with a daily oral dose of 200-300 mg. The reduction of hypertonia was assessed using the Ashworth Scale to evaluate symptoms and signs. On the whole 12 patients showed a clinical improvement; eight of them showed an improvement of at least 2 items on the Ashworth Scale. The reduction of hypertonia began on the 4-5th day of therapy, progressing until the 10-12th day of treatment and then remained constant. Tolerance was very good. Despite the low number of patients in the study the authors obtained good results suggesting that Trazodone should be studied further in this field.
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Epidemiological research has been carried out on multiple sclerosis in the province of Varese. The index of prevalence of the disease at 31-12-1975 was 24.176%. The geomedical figures for the province are reported and a comparison made with similar research carried out in 1966. The clinical aspects of the disease are discussed in relation to a group of patients from other Italian provinces.