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Biomedical subjects

A Zahaf

Publications and source records attributed to A Zahaf.

At least 55 records · Page 3Linked to original sources
PubMed1995

Comparative epidemiology of pemphigus in Tunisia and France: unusual incidence of pemphigus foliaceus in young Tunisian women.

Recent studies have suggested that in Tunisia, pemphigus foliaceus is more frequent in young women than expected. To confirm these findings, we compared the incidence rates of pemphigus in Tunisia as a whole and in a large area of France. New cases of pemphigus were detected retrospectively from dermatology departments and pathology laboratories over a 6-year period and classified as pemphigus vulgaris or foliaceus according to the pathology. In France, the incidence rate was 1.7 cases per million per year (95% confidence interval 1.4 to 2.1). Pemphigus vulgaris accounted for 73% of all cases, incidence increased with age, and the female-to-male sex ratio was 1.2. The incidence rate was significantly higher in Tunisia than in France: 6.7 cases per million per year (95% confidence interval 5.8 to 7.7); pemphigus foliaceus was more frequent (61%), the female-to-male sex ratio was 4.1, and the incidence rate was higher in young women. The incidence rate was 15.5 cases per million per year for pemphigus foliaceus among women aged 25 to 34 years and was even higher in some rural areas. No case was observed among household members or in neonates, and only one case occurred in childhood. Thus, we confirmed that the epidemiology of pemphigus in Tunisia is unusual. High rates of pemphigus foliaceus among young people living in rural areas are reminiscent of Brazilian pemphigus. However, the absence of cases among genetically related household members and during childhood, and the large predominance of women, contrast with Brazilian pemphigus.

Adult↗
PubMed1994

[Lyme disease in Sfax].

Primary borreliosis is exceptional in North Africa. From 1988 to 1992, we observed 23 cases (10 females, 13 males; age 20-67 years) of erythema chronicum migrans in our unit. The lesions began during the months of April to October with a peak in July and August. There was always an unique characteristic lesion with a central mark left by the bite in 20 cases. Serological studies were not performed. Several antibiotics were given. Primary borreliosis of the erythema chronicum migrans type are seen in Tunisia and probable throughout North Africa. The clinical presentations and seasonal distribution are the same as in Europe.

Adult↗
PubMed1991

[Systemic scleroderma in children. Apropos of 2 cases].

Two cases of systemic scleroderma in girls are reported. One patient, aged 11 years, has systemic scleroderma with Raynaud's phenomenon, and pulmonary involvement. The other, aged 8 years, has systemic scleroderma with lung involvement. The specific features of pediatric systemic scleroderma are reviewed briefly.

Child↗
PubMed1988

[Hereditary epidermolysis bullosa. Epidemiology and clinical classification of 23 cases].

The authors report 23 cases of hereditary epidermolysis bullosa (EB). An attempt has been made to classify them. It was based only on the clinical and genetic criteria. The EB simplex has been found in 14 patients, 5 cases were of the Köbner type. The other 9 cases were of the Cockayne-Weber type. EB dystrophica was isolated in 9 cases, 7 cases of which were carriers of the Hallopeau-Siemens form, one case of the pretibial form and one case of Bart syndrome. The frequencies obtained are largely above the values reported in the literature.

Adolescent↗
PubMedDate not supplied

[Giant sebaceous gland hyperplasia of the vulva].

BACKGROUND: Sebaceous gland hyperplasia is an epithelial tumour with sebaceous differentiation. Genital involvement is rare. In this paper, we report a new case of sebaceous gland hyperplasia of the vulva. CASE REPORT: A 27 year-old woman presented multiple polypoid lesions of the lower third of left labium majus. The lesions were soft to the touch, measured 5 cm in length and were painless. The cutaneous biopsy confirmed the diagnosis of sebaceous gland hyperplasia of the vulva. Surgical excision was performed in two separate procedures and was successful. DISCUSSION: This case was unusual in terms of the site, the clinical appearance and the weeping seen due to the high concentration of hyperplasic sebaceous glands.

Adult↗
PubMedDate not supplied

[Cutaneous lymphoma in Tunisia: clinical profile and therapeutic results].

PURPOSE: The aim of this retrospective study was to investigate therapeutic result of cutaneous lymphoma in Tunisia. PATIENTS AND METHODS: Between January 1969 and June 1994, 100 patients with cutaneous lymphoma were referred either to Salah Azaiz Institute or the other University Hospitals of Tunisia. Fifty-one patients had epidermotropic lymphoma and 49 non-epidermotropic lesions. Eighty-seven patients received complete treatment. Puvatherapy and other local dermatologic treatments were used for early stage mycosis fungoïdes. Thirty-two patients benefited from radiotherapy, with curative dose in 28 cases. Chemotherapy including anthracyclin agents was used for high grade lymphoma. Thirteen patients had association of radiotherapy and chemotherapy. RESULTS: Five-year survival rates were 50% for patients with epidermotropic lesions and 56% for patients with non-epidermotropic cutaneous lymphoma. Statistical study has not identified any significant prognosis factor. CONCLUSION: Radiotherapy and chemotherapy are both effective. Treatment should depend on stage and histologic type.

Adolescent↗
PubMedDate not supplied

[Necrobiosis lipoidica - 3 case reports].

Necrobiosis lipoidica is a rare degenerative disease mostly seen on the legs. The association to diabetes mellitus is usual. We report three patients with necrobiosis lipoidica located on the extremities, 2 of them were already treated for diabetes. Necrobiosis lipoidica has distinctive clinical and histological appearances. The lesions appear as well circumscribed, erythematous plaques, with a depressed centre. Some of these lesions may progress to ulcers. The legs are commonly involved. Angiopathy leading to thrombosis of the cutaneous vessels has been implicated in its pathogeny. There is no specific therapy for this disease Topical and/or intralesional corticosteroids are the most widely used treatment.

Adolescent↗
PubMedDate not supplied

[Discovery of 4 new cases of leprosy in a South Tunisian location].

Having found a new case of leprosy from Beni Khadech, the Sfax Service of dermatology has decided to investigate in two places in this region: Elmenzla and Gattar. Beni Khadech, an endemic region, has 30 cases of leprosy in 1978 over 164 declared in Tunisia. Over 1688 systematically examined patients, 4 new cases have been discovered and 3 of which are contagious ones.

Adolescent↗
PubMedDate not supplied

[Leprosy in South Tunisia. Preliminary study].

One hundred and nine leprosy cases have been recorded by the service of dermatology in Sfax (the only specialised centre in the south of Tunisia) during the last decade. These cases have been essentially assembled in two regions: Sfax and Malloulech. The lag of their finding and the ignorance of some other new cases are due to several factors.

Epidemiologic Methods↗