[Thin layer chromatography in the analysis of pharmaceutical preparations of phenolic character].
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Biomedical subjects
Publications and source records attributed to A Z Knizhnik.
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The authors review the principles of calculating the optimal dosage regimens of mebicar used in the treatment of borderline psychopathological abnormalities in alcoholics. Mebicar administered to patients according to the calculated dosage regimens ensures the positive clinical effect. This is supported by the clinicopsychopathological and electrophysiological data.
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Twenty-two patients admitted to the narcological clinic of an industrial enterprise were examined for the clinical effect and pharmacokinetic parameters after intake of a single dose of a Soviet psychotropic drug mebicar. The clinical status was assessed by means of psychometric mapping and concurrent recording of the EEG. The correlation of the pharmacodynamic and pharmacokinetic data can be used for the choice of minimal effective concentrations applied in further calculations of individual dosage regimens.