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Biomedical subjects

A Yanagiya

Publications and source records attributed to A Yanagiya.

8 recordsLinked to original sources
PubMed1992

Prolongation of second heart transplants in rats.

Second clinical kidney grafts often survive longer than first grafts. Using a rat cardiac allograft model, we examined the conditions under which survival of a second graft can be longer than first graft survival. In the BUF-to-LEW combination, following rejection of the first transplant, second cardiac allografts from the same donor strain implanted immediately survived longer than the first grafts (P = 0.047). Although the mean survival time of first grafts was 9.0 days, second grafts implanted in the same animals survived 19.5 days. In contrast, when ACI donors were used for the same LEW recipients, the second grafts were rejected in 3 days compared with 6.6 days for first grafts. Donor-specific spleen cell transfusions in these combinations resulted in prolonged survival in the BUF to LEW combination, but had no effect when the donor strain was ACI. Second grafts from BUF had prolonged survival following rejection of the first graft. Thus the histocompatibility difference was a determining factor of whether or not prolongation would be obtained. Another factor was timing of the second transplant. If 7 days were allowed to elapse following rejection of the first graft before implantation of the second, the enhancement effect was lost. Moreover, in the LEW-to-ACI combination in which second grafts were rejected rapidly, removal of the first graft after 7 days (before rejection), resulted in prolonged survival of the second graft. There is, therefore, a window of time before rejection of first grafts and shortly thereafter, when the enhancement effect can be obtained. Passive transfer of serum in the BUF-to-LEW combination resulted in enhancement, but transfer of splenic cells was ineffective. We conclude that graft rejection can result in induction of enhancement during a specific period, after which this effect is lost; and that enhancement can be obtained only in certain strain combinations. This suggests that human patients with heart transplants that reject might benefit from a second graft, even from a donor with a mismatch similar to the first graft.

Animals↗
PubMed1989

Second transplants.

1. One-year graft survival for recipients of second cadaver renal allografts was 66%, 10% below that of first transplant recipients. The poor second graft survival rates have not improved since the introduction of cyclosporine A in 1984. 2. The major difference between first and second transplants was a higher rate of immunological failures in the first 3 months. Whether or not the second transplant functioned on the first day was a good indication of the outcome. 3. The degree of HLA mismatching in the first transplant affected second graft survival. When there were no HLA-B,DR mismatches in the first transplant, 1-year second graft survival was 72% compared to 66% when there were mismatches. 4. HLA-A,B,DR matching in the second transplant also improved second graft survival from 65% for completely mismatched grafts to 78% when there were no antigens mismatched. 5. The duration of the first transplant was an important consideration in second graft survival. When the first transplant had functioned for more than 1 year, second graft survival was 74%. When the first graft had been lost within 3 months, second graft survival was less than 60%. 6. Early second graft function in patients whose first transplant had functioned more than 6 months paralleled that of first transplant recipients. When the first transplant was lost within 6 months, 30% of second transplants never functioned or were lost in the first month. With a longer duration first graft, only 10% were lost in the first month. 7. Sensitization, though a predictive factor of second graft survival, was less informative than the first transplant duration.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Transfusion↗
PubMed1989

[The effects of aorto-coronary bypass grafting on left ventricular diastolic function in patients with left ventricular dysfunction].

To determine the effects of aorto-coronary bypass grafting on left ventricular diastolic function in patients with low ejection fraction (EF less than or equal to 0.40), 17 patients were studied. They were divided into two groups, Group I: 8 patients without previous myocardial infarction, Group II: 9 patients with previous myocardial infarction. Left ventricular diastolic function was assessed by maximum negative dp/dt, constant T, diastolic compliance and 1/3 functional filling. In conclusions, when ejection fraction is depressed (EF less than or equal to 0.40), myocardial revascularization improves left ventricular diastolic function in patients without previous myocardial infarction, but not with previous myocardial infarction.

Aged↗
PubMed1987

[A case of aneurysmal dilatation of a saphenous vein graft for subclavian aneurysm in a patient with Behçet disease].

The autogenous saphenous vein is the preferred conduit for repair of occluded arteries in the limb and coronary arteries. The aneurysmal dilatation of the vein graft is a unusual complication in the long-term period. A case of aneurysmal formation of the vein graft for the subclavian aneurysm 5 years after grafting with classic Behçet disease was reported. The etiology of this rare complication and the special surgical problem were also discussed.

Adult↗