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A Yagüe

Publications and source records attributed to A Yagüe.

9 recordsLinked to original sources
PubMed2000

Modelling and forecasting antimicrobial resistance and its dynamic relationship to antimicrobial use: a time series analysis.

To investigate the relationship between antimicrobial use and resistance in our hospital, we collected antimicrobial susceptibility and use data from existing microbiology laboratory and pharmacy databases for the period July 1st, 1991-December 31, 1998. The data was analyzed as time series and autoregressive integrated moving average (Box-Jenkins) and transfer function models were built. By using this method, we were able to demonstrate a temporal relationship between antimicrobial use and resistance, to quantify the effect of use on resistance and to estimate the delay between variations of use and subsequent variations in resistance. The results obtained for two antimicrobial-microorganism combinations: ceftazidime-gram-negative bacilli and imipenem-Pseudomonas aeruginosa, are shown as examples.

Anti-Bacterial Agents↗
PubMed1998

Intrinsic viscosity calculated out of single point measurements for chondroitin-4-sulfate and chondroitin-6-sulfate solutions.

The differences in the structure of polymer chain between the chondroitin-4-sulfate (C4-S) and the chondroitin-6-sulfate (C6-S) are reflected in the intrinsic viscosity values calculated starting from the traditional methods of Huggins, Kraemer, Mead and Fouss, and Martin, and by the method for a single-point determination of intrinsic viscosity [eta]. For the range between 0.4 and 0.5% (w/v) concentrations, we get an agreement in the intrinsic viscosity values. The chains of both polymers present a flexible structure and are not ramified between 0.28 and 1.00% (w/v) concentrations.

Algorithms↗
PubMed1993

[Enteric fever caused by multiresistant Salmonella typhi: 2 autochthonous cases].

BACKGROUND: References about isolation of strains of Salmonella typhi multiply resistant to antimicrobials and native from Spain are very scant. We describe here two cases of typhoid fever produced by two identical strains of Salmonella typhi. Both strains are multiresistant and autochthonous, judging from epidemiological investigations. METHOD: Microbiological diagnosis was made by means of isolation of causative microorganism from blood and stool, in the first case, and only from stool, in the second one. Antimicrobial susceptibility was ascertained using a minimal inhibitory concentration micromethod. RESULTS: Identification of Salmonella enterica ser. typhi and determination of its resistance to many antimicrobials. Native origin of both strains verified by means of epidemiological investigation. Healing achieved in both cases with ciprofloxacin. CONCLUSIONS: We stand out the rarity of isolating native multiresistant strains of Salmonella typhi in our country, as well as the great epidemiological interest of our finding. We think that diagnosis of these diseases must be made by culturing suitable specimens and isolating causal microorganisms, what will us to determine antimicrobial susceptibility. Finally, we emphasize the resolution of the illness with ciprofloxacin. We consider that this third generation quinolone is a suitable alternative in these cases.

Adult↗
PubMed1992

[Empyema due to Moraxella (Branhamella) catarrhalis].

We present a case of empyema by Moraxella (Branhamella) catarrhalis in a patient affected by a bronchogenic epidermoid carcinoma. We describe the basic clinical characteristics of the infection by Moraxella (Branhamella) catarrhalis and we confirm the low incidence of empyema by such germ.

Aged↗
PubMedDate not supplied

Mucopolysaccharides in aqueous solutions: effect of ionic strength on titration curves.

We study the changes taking place in hyaluronic acid, chondroitin 4-sulfate (C4-S) and condroitin 6-sulfate (C6-S), at ionic strengths of 0.10, 0.15, and 0.20 in NaCl, in a neutralization process in aqueous solution. We apply the equation of Henderson Hasselbalch modified for polyelectrolytes and evaluate the changes in the electrostatic free energy starting from the pK curves as a function of the dissociation degree. For a dissociation degree next to 0.4 corresponding to the -COOH group of the hyaluronic acid, we observed a change in the conformation of the three glycosaminoglycans studied. This conformational change takes place as a consequence of the break of intramolecular links and the beginning of the ionization process. The macromolecules in solution show a structure of random coil sufficiently expanded so that the interaction among the close ionizable groups is negligible.

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