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Biomedical subjects

A Yabrov

Publications and source records attributed to A Yabrov.

At least 19 recordsLinked to original sources
PubMed2001

A theory of cellular-function pathology: further development of Virchow's theory of cellular pathology.

A new theory of pathology is introduced. The human cell is an organism in itself. It fulfills both cell-oriented and organism-oriented functions. Impairment of either one of these functions may lead to disease. This means that a structural lesion of a cell is not a sole and necessary cause of the beginning of disease. When a cell-oriented function is impaired the cell suffers, but the overt symptoms at the organ-organism level might be absent for a very long time. This is how a chronic asymptomatic disease starts. Measures of prophylaxis, diagnosis, and treatment should be centered upon maintenance and restoration of a balance between the cell-oriented and organism-oriented cellular functions.

Humans↗
PubMed2000

It is hazardous to treat HIV patients with interferon-alpha.

Interferon-alpha is shown to play a key role in the progressing immunodysfunction that characterizes HIV infection. In particular, interferon-alpha is responsible for the development of an autoimmune state that is prone to serious complications. Therefore, treatment of HIV patients with IFN-alpha is hazardous. There are results suggesting that anti-interferon-alpha immunization might be a method for prophylaxis and treatment of the autoimmune state in HIV patients. This treatment may prevent complications of HIV infection and the transition to AIDS.

HIV Infections↗
PubMed1988

Aspects of perceptual development and rehabilitation.

It is hypothesized that two anatomically distinct structures--sensory and cognitive--are jointly responsible for perception. In normal individuals the sensory structure is developed at birth, whereas the cognitive one develops after birth under the influence of information received through the sensory structure. Only information that is consciously perceived and comprehended is essential for development of cognitive structure. Consequently, creation of an optimal substream of this cognizable information is an important objective for the therapist or teacher.

Cognition↗
PubMed1988

New approach to treatment of AIDS and AIDS related complex.

A new approach for treatment of AIDS is suggested. This is to isolate the patient's blood, to remove anti-T-cell substance from the plasma, and treat the cells with an anti-viral agent. And then return it into the patient.

AIDS-Related Complex↗
PubMed1987

General mechanism of chronic diseases.

In a human, the cells function adequately to the needs of the organism, and to their own needs. Consequently, adequate cell function is comprised of the organism-oriented, and cell-oriented functions. It is suggested that an independent stage in the pathogenesis of a chronic disease exists which so far has not been considered. This is the disturbance of the cell-oriented function of the cells involved. This initial stage may last for years and decades, whereas function of the organ remains preserved. Organism-oriented cellular function appears to become involved in the pathologic process long after the disease has actually started. At this time the cells themselves are severely impaired, and as a result a disease acquires its progressive, irreversible course. Pathogenesis of atherosclerosis is considered as an example of the above-mentioned developments.

Aging↗
PubMed1987

Theory of adequate function of cells and the organism--the theoretical basis for contemporary medicine.

The theory of adequate function of the cells and the organism is introduced as the theoretical basis for contemporary medicine. In accordance with this theory, the organism tends to function adequately to the needs directed toward the maintenance of life under various conditions. Mechanisms responsible for adequate function include those of regulation, compensation and defense. Their interactions provide for adequate function in both steady and transient physiological conditions, as well as in pathological conditions. Examples of adequate function under various conditions are discussed. The notion of optimal adequate function of cells and the organism is introduced, which implies the complete satisfaction of the needs of the cells and the demands imposed upon these cells by the organism. The dual character of the cell's adequate function contributes to the possibilities for disease. Imbalance between the needs of the cell and the needs of the organism is proposed to be the general mechanism of chronic diseases. Maintenance of the optimal balance of adequate function throughout the life of an individual is considered to be the major objective through which the prophylaxis and early treatment of chronic diseases can be achieved.

Adaptation, Physiological↗
PubMed1986

Lymphocyte emperipolesis into autologous monocytes in leukocyte cultures exposed to mitogenic lectins.

Lymphocyte-monocyte synergistic interaction in cooperative response to mitogens and antigens is well established. This paper describes a less known--antagonistic (effector-target)--lymphocyte-monocyte interaction that came into existence in a leukocyte culture after the commencement of cellular response to concanavalin A, phytohemagglutinin and Wistaria floribunda mitogen. An invasion of lymphocytes into monocytes and monocyte polykaryons has been found 24-48 h after exposure to mitogens. The invasion is not followed by lysosome fusion with lymphocyte-bearing vacuoles, but is associated with a sequential destruction of the vacuole wall, and eventual disintegration of some affected cells. The expression of pan-T-cell surface antigens, staining patterns for nonspecific esterase and acid phosphatase as well as ultrastructural features show that the lymphocytes entering into and those located within monocytes and polykaryons represent activated T-cells. The presence of developed Golgi complexes associated with coated and smooth vesicles, and lysosomal bodies with microvesicles, tubular arrays or dense cores suggest that these T-cells belong to subpopulations which possess cytolytic activities. The lymphocyte invasion is considered cytolytic emperipolesis directed towards some autologous cells of the mononuclear phagocyte series. Its extent depends upon the mitogen concentration, and density of cell population in the culture. It also shows individual variability. The relationship of cytolytic emperipolesis to phagocytosis, and its possible significance as a mechanism of cell-mediated elimination of undesirable cells is discussed.

Antigens, Surface↗
PubMed1986

Reorganization of contemporary medical practice.

A research project now in development at Rutgers University is discussed. Its aim is to elaborate a comprehensive program for the physician which he or she could use for a continuous individualized treatment of a healthy person with the aim of preventing development of a chronic disease.

Chronic Disease↗
PubMed1986

Medicine in the long-living society.

Contemporary medicine is faced with a new objective--control over chronic diseases. In order to achieve it, new approaches in theory and practice should be explored.

Chronic Disease↗
PubMed1986

General principle of existence of natural objects.

Natural objects, live and inanimate, actively maintain their entities by using their capacities (i.e., properties, internal resources, mechanisms, and experience) adequately to their needs. It is suggested that the principle of adequate function is a law of nature.

Biology↗
PubMed1980

Adequate function of the cell: interactions between the needs of the cell and the needs of the organism.

The continuous maintenance of cell adequate function (cellular stress) is considered to be the main feature which characterizes the activity of a live cell. In accordance with the concept of cellular stress, the transition of the cell to the state of adequate functioning represents a dual commitment. The cell must function adequately to respond to the demands of the organism and to provide for its own needs. Thus, it is proposed that two systems exist for the regulation of the adequate function of the cell: one enabling the cell to respond to the demands of the organism, and the other providing for the needs of the cell itself. The hormonal system of the organism represents the first of these mechanisms, and I believe that another system exists for regulation of intracellular needs. Adequate function of the cell is determined by the regulative, controlling and defense mechanisms. The balance between the needs of the cell and of the organism should be a concern of physician, since it provides for the optimal function and health of the organism as a whole.

Adaptation, Physiological↗
PubMed1979

Interferon and cell-mediated immunity.

The thesis is introduced that the phenomena of cell-mediated immunity proceed with the necessary involvement of interferon. In view of this thesis various examples of cell-mediated cytotoxicity both antibody-dependent, and antibody-independent are analyzed. The role of interferon in transplantation, allergic diseases and the treatment of cancer is also discussed. Based on this analysis it is concluded that interferon provides for the cytotoxicity of immune and non-immune leukocytes. It is suggested that interferon is responsible for the cytotoxic effect in itself, since it facilitates lethal hybridization. Recognition of the important role of interferon in the mechanism of cell-mediated immunity leads to some practical conclusions: a) The selective inhibition of the activity of type II interferon may be a sufficient measure in cases where now total immunosuppression is applied. b) Periodic treatment of healthy population by lymphokine stimulants may be a method of prevention of cancer. c) Transplantation, allergic diseases, immunotherapy of cancer should be considered in terms of the role of interferon in these processes.

Autoimmune Diseases↗
PubMed1979

Maintenance of the adequate function is a general principle of survival of organisms.

A general theory which describes the existence of live organisms is introduced; this theory is the Principle of Adequate Function and it describes all the situations in which live organisms may exist, whether healthy or sick at both physiological and pathological conditions. In biology, so far, the existence of living organisms under physiological conditions is described by homeostasis, and under pathological conditions specific immunity is used. As it is shown below, adaptation and non-specific resistance provide a much broader basis of how living organisms exist under both physiological and pathological conditions. This general theory does not interfere with the notions of homeostasis, adaptation, and specific immunity but includes them as particular cases. It is proposed that the principle of adequate function supplements the description of life processes by the evolutionary principle; it describes the laws of existence and function of a particular individual.

Adaptation, Biological↗