Search PubMedSearch

Biomedical subjects

A Xypolyta

Publications and source records attributed to A Xypolyta.

9 recordsLinked to original sources

Malignant fibrous histiocytoma. Review of the literature and report of a case in a four-year-old child.

A case of fibrous histiocytoma is presented, originally diagnosed as aggressive, which eventually ran the course of fibrosarcoma. We feel that when dealing with any form of "fibromas" one must be very careful as far as the diagnosis and the prognosis are concerned, because there are no clear histological and clinical borders between the benign and malignant counterparts. A wide excision is required in most of the cases, if a recurrence is to be avoided, and a close follow-up to detect any metastasis. The term "aggressive" used in many such lesions could be a convenience in the face of inability to better describe the tumor, and inaccuracy should rather turn our attention towards the malignant side.

Child, Preschool

Uncommon manifestations of histiocytosis X.

Histiocytosis X is a group of disorders of uncertain etiology with a variety of manifestations that are usually related to the age of the patient. Treatment consists of local curettage, irradiation and chemotherapy. The prognosis depends on the systems involved. The oral and perioral tissues are occasionally involved and often lead to the diagnosis. We report a case with spinal cord involvement and a case of facial nerve paralysis secondary to involvement of the petrosal bone. Also included is a case of involvement of the mandibular condyle.

Bone Diseases

Cherubism.

Cherubism is a benign, hereditary giant cell lesion of the jaws, that appears in children as a bilateral painless swelling, between the ages of 2 and 5 years and progresses until puberty, when it spontaneously regresses. It normally requires no treatment. We had the chance to operate on a 5-year-old boy with cherubism 8 years ago, and used homogenous bone grafts to replace the diseased tissue to avoid pathological fracture of the mandible. Since then we have been following the patient, witnessing the gradual involvement of other sites in the jaws and the displacement of teeth and tooth germs.

Anodontia

Irradiation of the head. Immediate effect on growth hormone secretion in children.

Plasma growth hormone (GH) was determined in samples obtained hourly from 1000 h to 0700 h before, and after a 3 week course of "prophylactic" cranial irradiation, in ten leukemic children who had no clinical or laboratory evidence of central nervous system involvement. The mean per hour value of GH prior to irradiation (4.1 +/- 2.4 ng/ml) was similar to that of 7 endocrinologically normal children (4.09 +/- 2.4 ng/ml), a finding strongly suggesting normal pituitary function prior to irradiation. Following irradiation GH levels at each hour were, in general, lower than before. The difference is statistically significant at 0100 h. The peak GH responses were lower following than preceeding irradiation (p less than 0.02). The findings suggest an immediate suppressive effect of irradiadiation on the apparently normal hypothalamic pituitary axis in children.

Adolescent