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Biomedical subjects

A Wroński

Publications and source records attributed to A Wroński.

At least 19 recordsLinked to original sources
PubMed1986

[Mixed infections of the urogenital tract with Trichomonas vaginalis and yeast-like fungi in humans with reference to treatment].

Comparative studies on the incidence of mixed infections with T. vaginalis and yeast-like fungi in man carried out within the years 1969-1980 and 1981-1984 showed a progressive increase of this kind of disease. Clinical treatment with Clotrimazole was performed in 35 patients. Local therapy with Clotrimazole was effective, if 3-5 days later the patients receive Tinidazole at one dosage. In some patients, the therapy has to be continued with Metronidazole.

Administration, Oral↗
PubMed1985

[Trichomoniasis of the urogenital tract in patients hospitalized in 1976-1983].

We report on investigations carried out on T. vaginalis and mixed infection (T. vaginalis and yeast-like fungi). Special attention was paid to metronidazol resistance on T. vaginalis strains isolated from patients who had been repeatedly treated with this medicament. Therefore we point to the necessity of defining the patients' susceptibility to this remedy.

Adolescent↗
PubMed1983

[Diagnostic and epidemiologic significance of multinuclear and round forms of Trichomonas vaginalis].

Trichomonas are analyzed in the material taken directly from the urogenital tract of male and female patients cultivated on Roiron medium and using different methods for staining the preparations was carried out. It is observed that some of the preparations examined show round nuclear forms of T. vaginalis impossible the detect by laboratory methods used up to now. The techniques used in this study decrease the risk of false diagnosis of these forms of trichomoniasis by less experienced examiners thus facilitating correct diagnosis and therapy. It should be also said, that they are simple and easy to carry out in the laboratory.

Diagnosis, Differential↗
PubMed1983

[Effect of different cytostatic agents and antibiotics on the biology of Trichomonas in vitro].

The purpose of these examinations was an attempt to elucidate the influence of some cytostatic preparations (Fluorouracil, Triaziquone (Treminon), Mechlorethaminee Oxide Hydrochloride (Mitomen), Methotroxate, Mitomycins, Cyclophosphamide (Endoxan), Mechlorethamin (Nitrogranulogen) and antibiotics (Penicillin, Streptomycin, Aureomycin, Nystatin) on formation of the multinuclear forms of Trichomonas under the conditions of culture on artificial medium and to investigate the cidal and static effects of chosen cytostatics and antibiotics of different species of Trichomonas in vitro. It was found that Mechlorethamine (Nitrogranulogen) and Mitomycins have distinct influence on formation of the multinuclear forms of Trichomonas in culture. Similar effects were observed in the antibiotic group with aureomycin only if applied pure or combined with other antibiotic drugs. In addition, it was shown that Triaziquone (Treminon) exerts the strongest effects on the examined species of Trichomonas.

Anti-Bacterial Agents↗
PubMed1983

Clinical studies on the effectiveness of Wratizolin in the treatment of some dermatoses.

Clinical studies on therapeutic effectiveness of ITCL applied as 2-3% ointment, 2% cream and 2-3% lotion were carried out. The study material included 96 patients at the age of 9-80. Of this group, 19 patients were with herpes zoster, 16 with herpes simplex, 29 with eczema complicated by secondary bacterial infection, 30 with palm and foot pustulosis, 1 patient with actinic cheilitis and 1 with varicella. The results obtained have revealed that the preparation is particularly effective in the treatment of dermatoses induced by herpes zoster and herpes simplex virus.

Administration, Topical↗
PubMed1982

Identification and characterization of sulfhydryl-containing proteolytic fragments involved in the Ca2+-induced conformational change of beef brain S-100.

The Ca2+-dependent conformational alteration of the brain-specific S-100 protein was studied by reacting the protein with N-ethyl[2,3-14C]maleimide in the absence and presence of Ca2+ and under denaturing conditions. Peptic hydrolysates of the 14C-labeled protein were analyzed and fractionated by high-performance liquid chromatography. Labeled peptide fractions were characterized by high-voltage electrophoresis and TLC. A clear distinction could be made between two classes of sulfhydryl-containing fragments: (a) neutral, hydrophobic, and (b) acidic. Ca2+ markedly favored 14C incorporation into the former components, whereas the latter were readily available only under denaturing conditions.

Animals↗
PubMed1980

Effects of trichloroethylene inhalation on proteins of the gerbil brain.

Inhalation exposure of adult Mongolian gerbils to 320 ppm of trichloroethylene (TCE) during 8 weeks causes a decrease of soluble proteins per wet weight in frontal cerebral cortex, cerebellar anterior part of the hemispheres and in the posterior part of vermis, as well as in hippocampus, although the levels of S 100, a glial cytoplasmic protein, showed an overgoing increase back to control levels, or a significant increase. In the sensory-motor cortex, an overgoing increase of soluble proteins, as well as of the S 100, were observed during the exposure period. One of the major soluble polypeptides (m.w. 50,000--52,000) of cerebral cortex, the cerebellar hemispheres and the brain stem, decreased at the end of the exposure period. Possible candidates for such a polypeptide are among others the subunit of microtubular protein or a subunit of (Na+K+)-ATPase. The results show that inhalation of TCE effect various brain areas differently. The observed biochemical changes could be interpreted as an adaptation and in some brain areas neuronal cells seem to be more sensitive than glial cells to TCE.

Animals↗
PubMed1977

Amino acid incorporation into total protein and levels of S-100 protein in discrete rat brain areas after prolonged protein or amino acid restriction.

Young adult rats were fed an isocaloric diet for 28 days. The diet consisted of either 22% casein, or protein-restricted food consisting of a 5% mixture of soy and whey protein, or a synthetic amino acid mixed diet devoid of the essential amino acids tryptophan, valine, lysine, and threonine. The level of the nervous tissue-specific S-100 protein was quantified immunoelectrophoretically in 9 different brain areas. A marked decrease of S-100 was observed in hippocampus and posterior part of the cerebellar vermis per g wet weight in protein-restricted rats. An additional lowering was noticed in sensory motor cortex per mg soluble protein. This effect was potentiated with the amino acid-deficient diet. The in vitro incorporation of 3H-leucine into cerebellar proteins was slightly decreased in the low-protein-fed rats, and more markedly decreased in those receiving an amino acid-restricted diet.

Amino Acids↗