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Biomedical subjects

A Woscoff

Publications and source records attributed to A Woscoff.

At least 19 recordsLinked to original sources
PubMed2002

Mycosis fungoides presenting with extensive pyoderma gangrenosum-like ulcers.

Mycosis fungoides (MF) may present with atypical clinical manifestations. Usually it mimics various chronic dermatoses, with the appearance of ulcers during the tumour stage. Infrequently, cutaneous ulcers are the main or initial sign of lymphoma. We report the case of a man who presented multiple skin lesions that clinically appeared to be pyoderma gangrenosum (PG). However, histological and immunohistochemical examination revealed MF. This case illustrates that PG-like ulcers maybe atypical cutaneous manifestations of MF and exceptionally the presenting sign of this disease.

Biopsy, Needle↗
PubMed2000

Prevalence of cutaneous manifestations in 200 patients with eating disorders.

BACKGROUND: Eating disorders are increasing and show a variety of symptoms. They mainly include anorexia nervosa (AN), bulimia nervosa (BN), and eating disorders not specified (EDNOS). They predominate in females and represent an important danger, especially in teenagers. In serious cases, they may be life-threatening. Objective To determine the prevalence of cutaneous findings in patients with eating disorders and to compare the results with those found in the literature. METHODS: An observational, transverse, and prospective study was performed. Two hundred patients of recent admission to ALUBA (association that fights against BN and AN), a psychiatric unit for eating disorders, were included: 122 BN; 62 AN; 16 EDNOS. RESULTS: Patients with eating disorders show dermatologic manifestations (alopecia, xerosis, hypertrichosis, caries, nail fragility) that are secondary to starvation. Russell's sign, seen as calluses on the dorsal aspect of the hands, is a consequence of self-induced vomiting and the local trauma of the superior incisors. This sign represents a compensatory behavior to overeating and predominates in the BN group. CONCLUSION: The recognition of dermatologic signs could be of immense value and could lead to the early diagnosis and treatment of these eating disorders.

Adolescent↗
PubMed2000

[Diagnosis by electron microscopy of recessive dystrophic epidermolysis bullosa].

Inherited epidermolysis bullosa (EB) includes a number of distinctive diseases that are characterized by the presence of fragile skin and the tendency to develop blisters and erosions. The current classification separates the types of EB on the basis of the ultrastructural level of the blisters. The electron microscopy is very important for the diagnosis and in the recessive dystrophic EB shows that the lamina densa forms the roof of the blister and that the number of anchoring fibrils are absent or reduced. We present the case of a 30 year old woman with a diagnosis of recessive dystrophic EB diagnosed by electron microscopy.

Adult↗
PubMed2000

[Ulcerated cutaneous lymphoma. 10 years of experience].

Patients with lymphomas and cutaneous ulcers have a poor prognosis. Commonly the ulcers occur later in the course of lymphomas and may be the source of sepsis. From 59 patients with lymphoma and skin involvement, 12 patients who presented with ulcers were retrospectively analyzed between January 1990 to December 1999. More frequently ulcers were multiple, necrotic, infected and placed on tumors. Sepsis was the main cause of mortality in 10 patients and most cases were secondary to Staphylococcus aureus and Pseudomonas aeruginosa. Factors associated with poor prognosis were febrile neutropenia after chemotherapy and generalized involvement by the lymphoma. Mean survival of deceased patients after onset of ulcers was 6.27 months. We emphasize the importance of an appropriate microbiological study and a prompt therapy.

Adult↗
PubMed1999

Nevoid keratosis of the nipple.

A patient with nevoid keratosis of the nipple is described. The clinical features, histology, therapy, and prognosis are discussed.

Adult↗
PubMed1999

[PCR determination of an association between class II HLA and pemphigus vulgaris].

Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting the skin and mucous membranes. It is characterized by the presence of an autoantibody directed against desmoglein 3, which causes acantholysis and blister formation. In this study, we examined the HLA antigens of 30 caucasian argentinian patients compared with 199 controls. We used the PCR-SSO method (Polymerase Chain Reaction-Sequence Specific Oligonucleotide). We found that PV patients had significantly increased frequencies of HLA DR4 (RR = 3.80, P = 0.001) and HLA DR 14 (RR = 5.97, P = 0.0001). As in other populations, two associated alleles were found: the first was DR beta 1*0402 (RR = 44.70, P = 10.7) and DQ beta 1*0302 (RR = 71.82, P = 10(-7)) and the second was DR beta 1*1401 (RR = 117.94, P = 10(-7)) y DQ beta 1*0503 (RR = 86.95, P = 10(-7)).

Alleles↗
PubMed1989

[Contact dermatitis caused by heterologous proteins].

A patient (gastronomic employee) presented a sharp dermatosis of eczema type in both hands. Patch-test confirmed sensitivity to heterologous proteins contained in the squid, which he was accustomed to handling. Although the levels of the IgE were elevated, the final diagnostic was dermatitis by allergic heterologous proteins.

Adult↗
PubMed1989

[Ulcerative plantar lichen. Is it an indicator of an autoimmune disease?].

A 48 years old female has had erosive and ulcerative lichen planus with sores in both heals, onychodystrophy and typical lesions in oral mucous membranes. Laboratory examination revealed specific abnormalities indicative of autoimmune thyroiditis and primary biliary cirrhosis. This clinical variant of lichen planus was associated with immunological disturbances. Autoimmune diseases must be investigated in patients with erosive and ulcerative lichen planus.

Autoimmune Diseases↗