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Biomedical subjects

A Wolfson

Publications and source records attributed to A Wolfson.

36 records · Page 2Linked to original sources
PubMed1979

Side chain cleavage of some cholesterol esters.

For some time it has been known that the side chain of cholesterol sulfate is cleaved by the cleavage enzyme system present in bovine adrenal mitochondria without prior hydrolysis of the sulfate moiety. In this work, other inorganic esters as well as some organic esters of cholesterol were tested as substrates for this enzyme system. The results revealed that cholesterol nitrate, cholesterol phosphate, and a series of acyl esters of cholesterol can also be cleaved by the enzyme system to their respective pregnenolone derivatives without first being hydrolyzed to cholesterol. The rate of oxidation of the carboxylic acid esters decreased as the size of the acyl groups increased. Cholesterol stearate and cholesterol phosphate were demonstrated to be inhibitors of the side chain cleavage of cholesterol. While digitonin, as might be expected, inhibits the cleavage of cholesterol, it accelerates the oxidation of both cholesterol sulfate and cholesterol nitrate. The results reported in this paper add support to the previously proposed hypothesis that more than one cholesterol side chain cleavage enzyme system exists in adrenal mitochondria.

Adrenal Glands↗
PubMed1976

A comparison of process notes and tape recordings. Implications for therapy research.

The basic contention of many researchers is that process notes are not suitable for objective study of psychotherapy. We focus here on our contrasting assumption that process notes may be effectively used for certain kinds of psychotherapy research, particularly that which deals with thematic shifts occurring over a period of time. To test this, three classes of taped memories were examined for thematic shifts: memories of the patient's father, mother, and repetitive memories. The taped memories were then compared with the memories recorded in the analyst's notes. Compared to the tapes, process note memories were fewer in number, significantly condensed, and introduced a variety of distortions into the data. In spite of these differences, judgments by independent raters indicated that in all three classes of memories, the analyst's notes reliably picked up pertinent thematic shifts.

Adult↗
PubMed1967

Avian pineal gland: progonadotropic response in the Japanese quail.

Pinealectomy in juvenile Japanese quail (Coturnix coturnix japonica) exposed to stimulatory photoperiods results in delay of ovarian and oviducal development and decreased pituitary weight. These effects are transitory and occur during a phase of growth immediately preceding the onset of sexual maturity. No effect was found in males. These results suggest that the pineal gland in females has a stimulatory effect on gonadal growth during maturation.

Animals↗