Biomedical subjects
Publications and source records attributed to A Wodak.
Cryptosporidiosis was found in a patient with the acquired immune deficiency syndrome. The microbiological and morphological features of this newly recognized opportunistic infection are distinctive and diagnostic.
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50 patients with heart muscle disease have been investigated using routine invasive and non-invasive techniques, including endomyocardial biopsy. Enzyme activities in myocardial tissue obtained by biopsy have been measured in dilated cardiomyopathy and heart muscle disease and compared. Significant differences in enzyme activity have been found between dilated cardiomyopathy and alcoholic heart muscle disease when the groups are defined by detailed drinking histories. CPK (p less than 0.002), MDH (p less than 0.001), LDH (p less than 0.001) and alpha HBD (p less than 0.001). The changes in the enzyme levels may be an adaptive response to alcohol although serial study did not show a fall in enzyme activities after 3-6 months abstinence. Preliminary data furthermore indicates an association of the alpha HBD/LDH and LDH/CPK enzyme activity ratios and ejection fraction. This data supports the diagnosis of a specific heart muscle disease in response to alcohol excess.
A reanalysis was undertaken of survey and retrospective urinalysis data on patients remaining in an abstinence-oriented, public methadone maintenance program in Sydney, Australia. A comparison of urinalysis results with those of previous reports of Australian methadone programs suggests that the clinic's disciplinary program failed to reduce detected heroin use; morphine was detected in 27% of urine specimens. Women, those with a partner in methadone maintenance, and exprisoners were significantly more likely to submit morphine positive urines. When account was taken of subjects' General Health Questionnaire scores in a second logistic regression model, the more psychologically disturbed patients were one fifth as likely to submit a morphine positive specimen as the less disturbed. This and other findings are interpreted as indicating that psychologically disturbed patients who continued to use heroin were more likely to be expelled from or otherwise leave treatment than the less psychologically disturbed who continued to use heroin.
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