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Biomedical subjects

A Wiskemann

Publications and source records attributed to A Wiskemann.

At least 37 records · Page 2Linked to original sources
PubMed1978

Radiotherapy of mycosis fungoides: twenty years of experience with teleroentgen and low-voltage X-ray therapy.

Of 98 patients with mycosis fungoides, 55 have been treated with teleroentgen therapy and 43 with low voltage radiation at a shorter distance. Teleroentgen therapy is indicated in the stage of generalized eczematous lesions or superficial infiltration. According to the Hamburg method, a dose of 300 R was delivered to eight fields at a target distance of 120 cm. After a series of one to three treatments, 300 R, administered at three-week intervals, all lesions usually cleared. Small patches and deeply infiltrated lesions and tumors were treated with the same doses and intervals of low voltage X rays, the half-value depth corresponding to the depth of infiltration. After five years, 54% of all patients were still alive and after 10 years, 29% were still living.

Adult↗
PubMed1978

[X-ray irradiation of basaliomas on the eyelids. Irradiation technic and results].

98 patients suffering from basal cell carcinomas near the eye and treated with X-rays between 1962-1972 were followed up. The cure rate was 96%. The functional result was good in 86%. Nine patients suffered from epiphora. In four patients an ectropion had developed. The cosmetric result was excellent to satifactory in 98%. The advantages of X-ray therapy are not only the high cure rate but also the ease of ambulatory treatment.

Basal Cell Carcinoma↗
PubMed1977

[X-ray irradiation of dermatoses in the genital area].

Report on empirical data of X-ray treatment of dermatoses in the genital area, concerning indications, technique and results. Irradiations are mainly successful in large patches of Bowen's disease and Bowen's carcinoma as well as in Queyrat's erythroplasia and Paget's disease. Carcinomata of the penis should not exceed the stages T1-T2. Regression of Peyronie's disease is accelerated. Psoriatic lesions disappear following Grenz-rays without further topical treatment. Grenz-rays can also prevent or delay local recurrences of herpes simplex eruptions in the genital area.

Aged↗
PubMed1975

[Light-induced cancer].

After exposure of mice and rats to ultraviolet radiation, the yield of cutaneous carcinomas regularly depends on radiation dose and dose distribution. In man, according to comparison of radiation climate with cancer frequency and based on distribution studies of skin exposed to light, the rules are supposed to be of the same kind. Thereby, the latent period is additionally influenced by genetically determined radiosensitivity (melanin content; DNA repair and by the action of syncarcinogenic and concarcinogenic factors. The resulting correlations between UV-light absorption and initiation of cutaneous carcinomas are tight in spinocellular carcinoma, distinct in basaloma, and questionable in melanoma. By converting the estimated UV-radiation doses into "Biological Units", it is possible to determine the risk of cutaneous carcinoma induced by artificial radiation sources as compared with the risk by radiation from sun and sky.

Animals↗
PubMed1975

[Statistical evaluation of light protection factors].

The protection against erythema belongs to the cosmetic effects which lend themselves to mathematical treatment. It is demonstrated -- on the basis of the optimal definitions given by Ellinger and Schulze -- that the calculation of the mean value of the light-protection factor Q as hitherto in use, does not correspond to the real frequency-distribution. On the contrary there exists, independent of the radiation source having sunlike characteristics and of the distance from the radiator, a binary-logarithmic standard distribution. With reference to the gradation principles of the human skin a transformation of the pertinent differences of area is necessary first, i.e. a transformation responding to the Gaussian standard distribution principle. Tables are presented concerning the transformation and the practical evaluation of the light-protection factor Q. By aid of these tables a standardization of the factors Q measured by different authors has been attained as well as a standardized statistical-mathematical analysis. The investigation of the threshold dose producing erythema on the unprotected human skin has revealed a superposition of three frequency-distribution types (showing logarithmic distribution, too) having different standard deviations. The results of this entirely statistical classification permit a safe forecast: the sunburn protection inherent in the human skin is compounded of several contributing factors which are interconnected multiplicatively, not additively.

Erythema↗