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Biomedical subjects

A Wise

Publications and source records attributed to A Wise.

122 records · Page 7Linked to original sources
PubMed1975

Adipocyte number and size in hypothalamic obesity induced in weanling mice by gold thioglucose and bipiperidyl mustard.

Weanling mice were injected with gold thioglucose or bipiperidyl mustard which have been previously shown to cause obesity associated with ventromedial hypothalamic damage. There was an increase in both adipocyte number and size compared to controls. Several models of obesity are compared and a possible role for the hypothalamus in the regulation of fat stores is discussed.

Adipose Tissue↗
PubMedDate not supplied

Irreversible pulmonary toxicity after single course of BCNU.

Irreversible pulmonary interstitial fibrosis developed 36 days after a single course of BCNU (total, 400 mg) in a patient with a malignant brain tumor. The case is unique in that irreversible changes developed shortly after a single course of BCNU whereas heretofore such permanent changes have been associated only with multiple courses of the drug (2,000-4,000 mg). This suggests that individual differences in the local sensitivity of lung tissue may be as important as the dose of the drug in determining whether irreversible fibrosis will develop.

Brain Neoplasms↗
PubMedDate not supplied

Preoperative psychologic testing as a predictor of success in knee surgery. A preliminary report.

Preoperative psychologic test scores derived from the Minnesota Multiphasic Personality Inventory (MMPI) were evaluated as predictors of success after elective knee surgery. The patients were examined 1 to 3 years after surgery and were evaluated in terms of subjective improvement, pain, level of activity, work restrictions, swelling, and strength. Patients that had scored high on the hysteria and hypochondriasis scales of the MMPI showed less improvement after surgery than those patients scoring lower on these scales. The results indicate that personality factors may play an important part in the symptomatic success after elective knee surgery.

Athletic Injuries↗
PubMedDate not supplied

Longitudinal CT study of parenchymal brain changes in glioma survivors.

We reviewed the serial CT studies obtained between 1974 and 1986 of 31 patients with malignant glioma who survived for 2 to 11 years after surgical removal of their tumors. In all cases surgery was followed by radiation therapy to the head (6000 rad) and chemotherapy. Patients were divided into two age groups: those under age 40 (n = 13) and those over age 40 (n = 18). By 2 years all patients in the older group developed evidence of leukoencephalopathy characterized by periventricular zones of decreased attenuation. Only 58% of the younger group showed evidence of white matter changes at this point. All patients from both age groups who survived for 4 years developed leukoencephalopathy. The severity of leukoencephalopathy from 6 months after surgery and beyond was always greater in the older group. All patients developed cerebral atrophy as evidenced by sulcal dilatation and ventricular enlargement. Atrophy was progressive beginning with the first postirradiation scan, and was always more severe in the older patients. A significant difference was found in the clinical status of the two age groups as determined by the mental status score and the Karnofsky scale. Despite progressive brain changes, survivors under age 40 maintained a nearly normal mental status and Karnofsky scores until their death, whereas survivors over age 40 showed progressive clinical decline.

Adolescent↗
PubMedDate not supplied

CT prognostic criteria of survival after malignant glioma surgery.

The serial pre- and postoperative computed tomographic (CT) scans of 115 patients entered in the Cooperative Brain Tumor Study between 1975 and 1982 were analyzed in order to define CT prognostic criteria and to test the hypothesis that radical glioma surgery prolongs patient survival. The CT parameters of mass size, associated edema, and intensity of enhancement were quantitated on all scans. Clinical parameters evaluated included gender, age, length of survival, and useful (Karnofsky greater than 30) survival. Data analyses indicated postoperative residual tumor burden was inversely related to length of survival (p less than 0.01). Postoperative associated edema and intensity of image enhancement were also of prognostic value and showed an inverse relation to survival. Younger patients proved more likely than older patients to attain long-term survival. Residual tumor burden of less than 45 mm diameter on postoperative CT scans was associated with 70% chance of long-term survival. These findings support the radical surgical management of glioma.

Adult↗