[Histiocytosis X: mother-infant leukocyte chimerism?].
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Biomedical subjects
Publications and source records attributed to A Winter.
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Spinal dysraphism is relatively common in children and includes a wide spectrum of congenital anomalies in the normal closure of the posterior elements of the spine. The prognosis will depend mostly on early diagnosis and treatment. Occult spinal dysraphism may present without external anomalies and the diagnosis could be suspected lately, when neurological symptoms are present and often irreversible. Occult spinal dysraphism is frequently associated to a tethered cord, most commonly secondary to the presence of a lipoma. Ultrasonography has been proven highly sensitive in the detection of intraspinal anomalies, especially in the diagnosis of tethered cord, in children under two years of age due to lack of ossification of the posterior elements of the spine. Today ultrasonography should be the examination of choice in all those patients in whom some kind of spinal dysraphism is suspected. We report our experience with three infants with occult spinal dysraphism in whom diagnosis was initially made by US and later on proved by either computed tomography, magnetic resonance or myelography. All of them had corrective surgery and neurological abnormalities were not detected afterwards.
Intrauterine growth of 11,543 newborn infants, liveborn between 1978 to 1987 that met prospective selection conditions (without intrauterine growth retardation risk) and their data are reported. MBW and weight percentiles 10, 25, 50, 75, 90 from 26 throughout 42 week of gestational age are reported. Selection of cases was important in obtaining adequate percentiles of birth-weight vs gestational age. The intrauterine growth pattern herein reported is recommended for evaluation of chilean newborns, because it is different to that of some foreign countries and the studied sample seems representative of chilean babies.
Thirty one infants with moderate and severe protein-calorie malnutrition whose blood hemoglobin concentrations were higher than 10 g/dl were managed with diet supplements containing iron fortified cereals for three months. In addition, 17 of them were given an extra daily dose of elementary iron (3 mg/kg/day). Mean weight gain was similar in both subgroups but mean hemoglobin concentration raised by 1,2 g/dl among extra iron infants in contrast with no increase or even decreased hemoglobin levels at the end of follow up in controls, thus demonstrating the importance of adding supplementary iron to these children during the recovery period of under nutrition, even it the diet provides the usually recommended 8 to 10 mg/day of iron.
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