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Biomedical subjects

A Wilhelm

Publications and source records attributed to A Wilhelm.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Interposition arthroplasties in the area of the proximal carpal row (lunate and scaphoid replacement/partial replacement].

Prostheses are recommended for replacement of the scaphoid. Results of tendon interposition after resection of small proximal fragments are unpredictable. Therefore alternative procedures like liquid silicone casts or replacement by a lunate prosthesis (or part of the prosthesis of the scaphoid) have to be evaluated. If after removal of the lunate a prosthesis does not fit into the cavity we recommend filling this cavity with liquid silicone.

Arthrodesis↗
PubMed1982

Serum-sialyltransferase activity in cancer patients.

Serum-sialyltransferase activity was measured in serum samples of 116 patients with malignant tumors of various origins and different clinical stages using asialo-fetuin as the acceptor and cytidine-5'-mono-phospho[14C]sialic acid as the donor. Only patients with metastatic tumors had significantly elevated serum-sialyltransferase levels. Increased enzyme activity was also associated with rheumatoid arthritis and with acute hepatitis, whereas no significant alteration of enzyme activity was observed in cystic fibrosis patients. In a group of tumor patients, various additional tumor markers were determined (carcinoembryonic antigen, alkaline phosphatase: Regan isoenzyme, creatinekinase: BB-isoenzyme, lactatedehydrogenase: isoenzyme 5) and the data compared to the clinical diagnoses. The sensitivity and specificity of serum-sialyltransferase as a tumor marker is assessed.

Alkaline Phosphatase↗
PubMed1981

Detection of Legionella pneumophila capsular-like envelope antigens by counterimmunoelectrophoresis.

The capsular-like envelope of Legionella pneumophila strains Togus 1 (serotype 2) and Philadelphia 1 (serotype 1) was isolated and purified by column chromatography on Sepharose 6B. Antibody raised in rabbits to these two antigenic materials did not cross-react in gel diffusion. Upon electrophoresis followed by gel diffusion, the majority of both envelope materials was found to migrate towards the cathode. A minor antigenic component of each envelope only migrated slightly towards the anode. Using the envelope antigens and the two anti-envelope sera in a counterimmunoelectrophoresis (CIE) assay, positive results were only obtained when the antigenic materials were placed in the cathodal well. The Togus 1 and Philadelphia 1 antigens did not cross-react in CIE. The sensitivity of the CIE assay was poor (15.6 micrograms/ml by carbohydrate content) compared to its sensitivity in other microbial systems. Although CIE may not be a useful diagnostic aid in identifying Legionella species due to its low sensitivity, it may be of value in serotyping the microorganism since we did not see cross-reactivity between the two strains when anti-envelope sera were used.

Animals↗
PubMed1980

Topochemical variation of LDH and CK isoenzyme patterns in aorta.

LDH and CK isoenzyme patterns are determined electrophoretically (Beckman) from various aortic regions and layers and in atherosclerotic plaques as compared to control areas. Throughout consecutive layers of human aorta LDH isoenzymes show a continuous cathodic shift from both surfaces towards the center with a maximum between the inner and middle third. CK shows a heterogenous pattern with maxima at CK MM and CK BB and less CK MB. Most of the CK MM is located in the intima, the media contains more of CK BB. Regional analysis shows an anodic shift of CK from proximal to distal thoracic aorta. In experimental short term hypertension a definite anodic CK isoenzyme shift is observed with increased relative CK BB activity.

Animals↗
PubMed1980

[Treatment of the buttonhole phenomenon and similar functional deficiencies].

In the last 20 years we performed 28 operations in cases of button-hole deformities and 6 reconstructive procedures in similar cases caused by destruction of the extensor aponeurosis. In 15 cases of the first mentioned group we reinserted the central slip, which we advanced at the same time by a Lengemann suture, which works also by blocking the PIP-joint; in one case we reinserted according to KAPLAN as modified by VERDAN; in the other 12 cases the deformities were operated according to the methods of DOLPHIN, FOWLER, HELLMANN, LITTLER and EATON, MATEV, PIEPER, NICHOLS, and VERDAN. Based on these experiences the problem of the button-hole deformity can be regarded as sufficiently solved, provided that there is no substantial defect of the central slip. Of all the procedures we prefer the reinsertion of the central slip. For the treatment of deformities with loss of substance we have different surgical procedures at our disposal, the techniques of which are discussed. Due to the small number of cases of buttonhole deformity, there are a priori no optimal conditions for comparative studies, so that we could not evaluate the different surgical methods. Due to this, our therapeutic decision depends much more on the findings in each single case. Even in case of extensive destruction of the extensor aponeurosis we recommend reconstruction. We have seen that the patients in many cases estimate the results more highly than we had supposed, based purely on postoperative measurements.

Female↗
PubMed1980

[Analysis of sialyltransferase activity in human serum (author's transl)].

The activity of sialyltransferase in human serum was determined by a radiochemical assay with desialylized fetuin as acceptor. The precision of this method proved to be low. The effect of storage, temperature, concentration of hydrogen ions and other substances was investigated. As at least 5 pH-optima were found, multiple forms of sialyltransferase may well exist in serum.

Blood Preservation↗
PubMed1979

Obstruction of the duodenal bulb caused by gallstone perforation.

Because of acute symptoms in the upper abdomen, upper gastrointestinal endoscopy was performed in a 75-year-old female patient. A large (5 cm x 10 cm) perforated gallstone was embedded in the duodenum, causing complete obstruction of the duodenal bulb. The stone was removed via pylorotomy. A fistula remained between the gallbladder and the duodenum. Cholecystectomy was not carried out because of the unfavourable cardiac condition of the patients. There was no complications.

Aged↗
PubMed1979

[Treatment of arthroses of the carpal bones and the first carpometacarpal joint with liquid silastic implants].

In cases of resection arthroplasties of the carpometacarpal joint of the thumb we implant liquid silastic. This implant provides a good adaptation to the individual local situation and shows a good resistance to deformation. On the basis of our initial experience with this procedure we regard it as highly apt to provide an exactly fitting substitute in the wrist--especially in cases of an extirpation of the lunate bone.

Arthritis↗
PubMed1977

[Operation for draining the stomach by subtotal pyloro-myectomy with and without dilatation of the mucous membrane (author's transl)].

According to our experiences a pyloroplasty adequate in shape and function can be formed by a separate plastic surgical treatment of the serosa muscularis and mucosa, which can not only be carried out in a very simple way, but if strict attention is paid to its indications and the technical details are adhered to exactly, it also guarantees a complete normalization of evacuation of the stomach without dumping syndrome and duodenal reflux with satisfactory reliability. The necessary intervention consists essentially of a subtotal pyloro-myectomy which is combined with distention of the canal mucous membrane if it is too narrow.

Drainage↗
PubMed1977

[Management of epicondylitis humeri radialis through the decompression of the radial nerve].

The pain associated with refractory epicondylitis humeri radialis can be eliminated not only by denervation, i.e. palliatively, but also by decompression of the radial nerve in certain cases. We assume that the latter procedure eliminates an important cause of irritation, particularily by resection of the tendineous origin of the proximal caput of triceps muscle. In this respect we consider the inferior cervical syndrome, present in all cases, to be the primary pathogenetic factor in accordance with REISCHAUER.

Athletic Injuries↗
PubMed1977

[Functional mechanisms of the proximal ulnar nerve compression syndrome].

The proximal ulnar compression syndrome when it is not a result of trauma, tumors, inflammatory and degenerative processes, inborn deformations or external pressure, is caused by two mechansims, namely the pinching of the ulnar nerve between the proximal edge of the ligamentous and muscular coverings of the cubital tunnel and of the exit of the nerve from the tunnel under the tendinous arch of the flexor carpi ulnaris. The compression itself is dependent upon the possibility of subluxation of the ulnar nerve. Therapy should consists not only in "decompression", but also in a simultaneous anterior transposition of the ulnar nerve.

Elbow↗
PubMed1977

[Therapeutic possibilities in fibro-lipomatous hypertrophy of the hand and finger nerves].

If the main nerves of the forearm and wrist are effected with fibro-lipomatous hypertrophy, decompression can be performed as a palliative measure. As the disease is not pregressive, resection or defatting of the hypertrophic fascicles should be avoided. The fibrous and lipomatous tissue cannot be separated from the fascicles without damaging them, even if the finest microsurgical technique are applied. As the disturbance of motor function increases, reconstructive surgery is necessary. In the fingers the "tumor" can be resected completely; the sensation of functionally important areas should be reconstructed with a neurovascular island flap or local pedicle flaps.

Adult↗
PubMed1976

[Radial nerve compression].

A new compression syndrome of the deep branch of the radial nerve is described, in which a sudden anterior displacement of a part of this nerve under maximal tension is followed by an axonotmesis. This happens in an area in which the deep branch of the radial nerve crossed some narrow structures which are unyielding and have more compression strength (tense cords of connective tissue Fig. 3). The operative finding of a torsion of the injured fascicles justifies the correctness of the immediate operative revision; otherwise the nerve regeneration would be impaired by the torted empty endoneural tubes. This description is a further constribution not observed before to the compression syndromes of the radial nerve, since in 1970 the author was able to give an explanation for the pathogenesis of compression palsies of the radial nerve, unclear up to that time but observed after forceful muscle contractions again and again since the beginning of this century. This observation gives the evidence that the occurrence of a peripheral compression lesion of nerves is not bound absolutely on the existence of a "physiological narrowness" (fibrous or osteofibrous tunnel etc.). This is also true for the median nerve.

Humans↗