Statistical methods are available for performing a meta-analysis when the response variable of interest is the same in each study. Problems arise when studies exploring a common therapeutic question use different patient response types. This article presents statistical methods for combining studies which involve different classifications of response into ordered categories. The assumptions required for the stratified proportional odds model, on which the analysis is based, are discussed. The approach is illustrated using results from a series of studies investigating the prevention of gastrointestinal damage induced by non-steroidal anti-inflammatory drugs.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMedDate not supplied

Chemical emergencies and the Health Advisory Group on Chemical Contamination Incidents (HAGCCI).

The Health Advisory Group on Chemical Contamination Incidents (HAGCCI) (pronounced 'Hag-C'), is an independent advisory group which was established to advise Directors of Public Health throughout the United Kingdom (UK) and the Chief Medical Officers of the UK Health Departments on the medical aspects of major chemical contamination incidents involving air, soil or water. Separate arrangements exist for the provision of advice on chemical contamination of food. HAGCCI comprises a core group of three individuals, supported by a multidisciplinary panel of experts, and a secretariat provided by the Department of Health. We describe the role of HAGCCI within the overall framework of preparedness for the public health aspects of chemical emergencies.

Decontamination↗