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Biomedical subjects

A Welch

Publications and source records attributed to A Welch.

59 records · Page 4Linked to original sources
PubMed1987

Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strain.

Two patients with relapsing Clostridium difficile diarrhoea following metronidazole and vancomycin therapy were colonised with a non-toxigenic avirulent Clostridium difficile strain given orally in three doses. Both patients appeared to respond without side-effects. Oral bacteriotherapy with a defined nontoxigenic strain of Clostridium difficile would appear to represent an acceptable, alternative and novel way to treat hospitalised patients who relapse with Clostridium difficile diarrhoea after specific antibiotic therapy.

Aged↗
PubMed1985

Diarrhoea due to enterotoxigenic Clostridium perfringens: clinical features and management of a cluster of ten cases.

Clostridium perfringens has recently been shown to be associated with antibiotic-associated diarrhoea. We describe here the clinical features and management of an outbreak of diarrhoea in a Geriatric Unit. Ten cases were due to enterotoxigenic C. perfringens and in these cases there was a highly significant correlation with recent antibiotic administration (P = 0.0001). The importance of early recognition of C. perfringens as a cause of infective diarrhoea in the elderly is stressed.

Aged↗
PubMed1978

Antibiotics in acrylic bone cement. In vitro studies.

The effect of combining gentamicin and cephalothin with Surgical Simplex bone cement was tested in vitro. Experiments were designed to determine (1) quantitative elution rates and period of time the antibiotics were eluted and (2) effective bactericidal qualities. Both antibiotics were eluted from polymerized acrylic cement in large quantities within 24--48 hr after coming in contact with fluid and continued to be released in smaller amounts for 21 days to more than 175 days. This varied with the antibiotic, concentration of antibiotic in the cement, surface area of cement, and volume of elution fluid. Quantitative determinations of numbers of bacteria in broth cultures demonstrated that sufficient quantities of antibiotics were released to be bactericidal to microorganisms within 45 min to 20 hr. This was dependent on the type of antibiotic, type of bacteria, concentration of antibiotic in the cement, and time of contact.

Arthroplasty↗