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Biomedical subjects

A Weissman

Publications and source records attributed to A Weissman.

At least 127 records · Page 7Linked to original sources
PubMed1990

The effect of cervical cerclage on the course of labor.

Although it is generally believed that patients with previous cervical cerclage have abnormal labor patterns, there is little evidence to support this belief. We analyzed the pattern of cervical dilatation during labor in 114 women with cervical cerclage by the McDonald procedure who delivered vaginally at term and compared them with 150 normal laboring women. Similar patterns of cervical dilatation were found in both groups and there was no case of cervical dystocia, a commonly cited complication of cervical cerclage.

Adult↗
PubMed1990

Sonographic growth measurements in triplet pregnancies.

Sonographic growth curves of biparietal diameter (BPD), head circumference, abdominal circumference, head circumference/abdominal circumference ratio, and femur length were generated from 24 uncomplicated, concordant triplet pregnancies. These were compared with the standard curves derived for singletons used in our medical center. Slowing of BPD, head circumference, and abdominal circumference growth was noted in triplets from the 28th week of gestation, whereas the head circumference/abdominal circumference ratio was similar to that of singletons. Femur growth was parallel to that of singletons, although on the low margin of the two standard deviations. We conclude that the growth patterns of triplets are different from those of singletons. We suggest that femur length derived for singletons may be suitable for the follow-up of triplets. However, when growth retardation is suspected, the growth curves presented herein may be used to identify the growth-retarded fetus.

Abdomen↗
PubMed1989

Interstitial pregnancy: a diagnostic challenge.

A case report which illustrates the clinical problems and sonographic difficulties that accompany the diagnosis of interstitial pregnancy are reported. Non-specific clinical symptoms and normal sonographic findings do not always preclude interstitial pregnancy.

Adult↗
PubMed1989

The influence of increased seismic activity on pregnancy outcome.

The influence of increased seismic activity on pregnancy outcome was evaluated. A significant increase in delivery rate was noted during the 48 hours following an earthquake on all instances. In two out of five events, a significant increase in premature delivery rate was noted (p less than 0.05). Possible signs of fetal distress in utero were documented following these events.

Birth Rate↗
PubMed1989

A novel class of "GABAergic" agents: 1-aryl-3-(aminoalkylidene)oxindoles.

Antagonism of mercaptopropionic acid (MPA) induced convulsions, reflecting a GABAergic mechanism, was observed in a series of 1-aryl-3-(aminoalkylidene)oxindoles. Optimal MPA antagonism was associated with 3-halo, 3-alkyl, and/or 4-alkoxy substituents in the pendant aryl ring and with (dimethylamino)methylene, 1-(dimethylamino)-ethylidene and N-methyl-2-pyrrolidinylidene side chains. The precise mechanism of action of these agents is unclear at this time; however, they are not GABA mimics and they do not affect GABA levels. Like other GABAergic agents, these compounds are potent enhancers of benzodiazepine binding and they antagonize cyclic GMP elevations induced by isoniazid. Compounds from this series may therefore have potential therapeutic utility as anticonvulsants or anxiolytics.

3-Mercaptopropionic Acid↗
PubMed1989

Survival and long-term outcome of infants delivered at 24 to 28 weeks' gestation, by method of delivery and fetal presentation.

Significant advances in perinatal intensive care and the increased chances of neonatal survival that have evolved in the last decade have posed moral and medicolegal questions for obstetricians that are as yet unanswered. Aggressive delivery management and major interventions for infants who were not long ago considered to be nonviable have become increasingly common. On the other hand, reports of high incidence of handicaps in the survivors cause great concern and add to the dilemma facing obstetricians. In this study, survival and long-term morbidity in 169 infants delivered at 24 to 28 weeks' gestation have been analyzed according to method of delivery and fetal presentation. At 24 to 25 weeks, survival was extremely low (10.5%) while major handicap rate was very high (42.9%). Infants born at 26 to 28 weeks' gestation had a considerably higher survival potential (42% to 74%), with an incidence of major handicap of less than 10%. At 26 to 28 weeks, abdominal delivery did not alter survival prospects of vertex-presenting infants; however, it improved survival of breech-presenting infants (70.0% compared with 22.2%) and showed a trend toward a lower handicap rate in the survivors.

Blindness↗
PubMed1989

Digoxin-like immunoreactive factor in twin and pregnancy-associated hypertensive pregnancies.

The objective of this study was to measure maternal total digoxin-like immunoreactive factor levels in singleton pregnancies with or without hypertension and in twin pregnancies. Plasma digoxin-like immunoreactive factor was measured in 113 third-trimester patients: 51 normotensives, 20 preeclamptics, 19 with latent or chronic hypertension, and 23 with twin pregnancies. The concentration of total digoxin-like immunoreactive factor in the twin gestations (1143 +/- 249 pg/mL) was significantly higher than that in either the normotensive pregnancies (890 +/- 161 pg/mL) (P less than .001) or in the hypertensive pregnancies (903 +/- 256 pg/mL) (P less than .01). However, there were no significant differences in digoxin-like immunoreactive factor levels between the normotensive and hypertensive groups. A trend of higher, although not statistically significant, levels of digoxin-like immunoreactive factor was noted in the chronic hypertensive group as compared with the preeclamptic patients (957 +/- 212 versus 852 +/- 288 pg/mL). We therefore conclude that digoxin-like immunoreactive factor does not contribute significantly to the pathogenesis or prediction of preeclampsia. The increased amount of digoxin-like immunoreactive factor in twin pregnancies may reflect a contribution from multifetal origin, or might be a physiologic adaptive mechanism allowing higher cardiac output by a possible cardiotropic effect.

Adult↗
PubMed1988

Single-dose cefazolin prophylaxis for cesarean section.

In a prospective, randomized trial, the efficacy of a single-dose, first-generation, long-acting cephalosporin was compared with a three-dose regimen in a group of 100 women undergoing cesarean section who were at high risk for postoperative febrile morbidity. Fifty women received a single 1 gm intravenous dose of cefazolin and 50 received 1 gm of the drug followed by two additional doses, 8 hours apart, to complete a three-dose regimen. Another 50 women, considered to be at low risk for postoperative febrile morbidity, were not given antibiotic prophylaxis. Outcomes of febrile morbidity (18% vs 12%) and particularly morbidity caused by endometritis (6% vs 8%, respectively) were similar for single-dose and three-dose groups. In the untreated low-risk group there were no cases of endometritis and the febrile morbidity was comparable to that of the prophylactically treated groups (14% vs 15%). Single-dose cefazolin prophylaxis appears to be comparable to multidose prophylaxis in reducing febrile morbidity after cesarean section.

Adult↗
PubMed1988

Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride.

The (R)-(+)- and (S)-(-)-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-(-)- and (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-(+)-enantiomer inhibited binding 29 times more potently than the (S)-(-)-enantiomer.

Animals↗
PubMed1988

Low birthweight breech infant: short-term and long-term outcome by method of delivery.

The effect of the delivery method on the short-term and long-term morbidity and mortality of the very low birthweight breech-presenting infants was evaluated. Although some previous studies question the benefit of cesarean section for the premature breech infants, the mortality rate and the incidence of birth injuries were significantly lower in the abdominally delivered group than in those delivered vaginally. The long-term follow-up clearly demonstrates that the vaginally delivered infants had a substantially higher incidence of cerebral palsy, visual damage, deafness, and severe developmental delay. It is concluded that cesarean section may be the preferred delivery method for the breech-presenting infants weighing 1000 to 1999 gm, offering a better quality of life.

Birth Injuries↗
PubMed1987

Uniform presentation of data concerning cesarean sections.

Many studies concerning the various aspects of cesarean section have recently appeared in the literature. The important issues are the changing indications for the operation and the different management protocols in trial of labor following a previous cesarean section. As the different authors use different ways of presenting their results, comparison of these studies is a complex matter and the conclusions are sometimes misleading. It is proposed that the data presented should be more uniformly used, according to the principles presented in this study.

Cesarean Section↗