Search PubMed⌕ Search

Biomedical subjects

A Weis

Publications and source records attributed to A Weis.

31 records · Page 2Linked to original sources
PubMed1989

Islet transplantation in experimental diabetes of the rat. XII. Effect on diabetic retinopathy. Morphological findings and morphometrical evaluation.

Digest-preparations of rat retinal vasculature were examined with respect to single capillary alterations and diffuse changes in cellular composition. Retinas of streptozotocin-diabetic rats revealed single micro-aneurysms, degenerated capillaries, strand formation, microthromboses and further lesions, occurring sooner than previously described. A severe loss of pericytes and a slight increase in endothelial cell number resulting in an increase in E/P-ratio were observed, all effects becoming more pronounced with longer duration of diabetes. Syngeneic islet transplantation could prevent all of the described alterations if carried out soon after diabetes induction. If performed six months later it was able to almost restore the normal cellular composition while pathomorphological lesions could be arrested or reversed only partially.

Animals↗
PubMed1988

Cooperative care: an application of Orem's self-care theory.

Cooperative Care provides acute care patients the opportunity to function with maximum autonomy during all or part of their hospitalization. Based on the self-care theory of Orem, it enables patients and their families to have increased participation in the health care process. Nursing care is available but the role is primarily that of educator and skilled observer as the patients and families assume responsibility for activities of daily living. This paper describes the Cooperative Care Unit at the Medical Center Hospital of Vermont (MCHV).

Evaluation Studies as Topic↗
PubMedDate not supplied

Diagnostic value of bone and tumour markers in patients with malignant diseases.

INTRODUCTION: Biochemical bone markers, such as the bone isoenzyme form of alkaline phosphatase, have been used to assess the bone formation phase of bone turnover in health and disease. Skeletal metastases often occur in patients with malignancies. Recent developments suggest that bone markers could be valuable clinical tools for the management of patients with metastatic bone disease. PATIENTS AND METHODS: Serum levels of BAP, along with serum levels of beta-CrossLap, were measured in a large group (n = 200) of patients with newly-diagnosed or progressive cancer of the prostate, breast, colon, liver and pancreas. Tumour markers such as PSA, CEA, CA 19-9, AFP, CA 15-3 and bone marker levels were correlated with the presence or absence of bone scan-documented metastases. RESULTS: Both of the bone markers examined were elevated in a high proportion of patients with confirmed metastases to bone. All patients with prostate, breast and colon carcinoma showed elevated beta-CrossLap values. The determined values of beta-CrossLap and BAP were significantly correlated with the number of skeletal metastases. CONCLUSION: Markers of biochemical bone remodeling can be used in assessing and managing patients with malignancies that metastasize to bone. These markers are abnormally raised in the blood of patients with metastatic bone disease.

Alkaline Phosphatase↗