Biomedical subjects

A Weinstein

Publications and source records attributed to A Weinstein.

150 records · Page 9Linked to original sources

PubMedDate not supplied

Low dose methotrexate in rheumatoid arthritis.

A systematic analysis of the efficacy of methotrexate (MTX) in severe rheumatoid arthritis (RA) was carried out. Twenty-one patients with severe classical RA resistant to conventional therapy were treated with 7.5 to 25 mg of oral or intramuscular MTX for 3-114 weeks (mean of 38 weeks). Eleven patients (52.4%) showed definite clinical improvement and a fall in sedimentation rate; some improvement was seen in 5 other patients (23.8%). Two patients were unresponsive. Three patients discontinued MTX, 1 because of acute hepatitis and the other 2 because of noncompliance and fear of toxicity. Abnormal liver function tests reversible with modification of therapy occurred frequently. Other side effects were minor. The results of this uncontrolled study indicate that MTX may be an effective drug for the treatment of severe RA. Double blind trials and longterm followup are needed prior to its widespread use in RA.

Adult↗

PubMedDate not supplied

Hairy cell leukemia and vasculitis.

A patient with hairy cell leukemia, systemic vasculitis, and HB8 antigenemia is reported. The patient presented with polyarthralgia before the diagnosis of the leukemia and had documented polyarthritis before the subsequent recognition of the vasculitis. The association of systemic vasculitis and hairy cell leukemia in the setting of HB8 antigenemia is discussed. The therapeutic challenge of treating coincident hairy cell leukemia and vasculitis is presented.

Adult↗

PubMedDate not supplied

Whither Westergren--the sedimentation rate reevaluated.

The term "Westergren sedimentation rate" implies that a standardized test is being performed. Questionnaires sent to 177 rheumatologists and 150 clinical laboratory directors showed that a variety of techniques are used to perform the sedimentation rate by the "Westergren" method. A comparative study revealed that the most reproducible results could be obtained with the classical Westergren technique or with a modified Westergren technique using EDTA anticoagulated blood and saline diluent. The use of undiluted whole blood in a Westergren tube was less reproducible and compared poorly with the classical Westergren technique. The results confirm that the undiluted Westergren technique should not be used and that in clinical studies the technique employed for determining the sedimentation rate should be specified.

Arthritis, Rheumatoid↗

PubMedDate not supplied

The coexistence of rheumatoid arthritis and systemic lupus erythematosus: a case report and review of the literature.

We describe a patient with longstanding classical erosive rheumatoid arthritis (RA), who after many years developed the clinical and serological manifestations of systemic lupus erythematosus (SLE) including diffuse proliferative lupus nephritis. She fulfilled the ARA preliminary criteria for the classification of SLE as well as the ARA criteria for classical RA. In addition she had antibodies to native DNA, hypocomplementemia, and deposits of immunoglobulins at the dermal-epidermal junction of the non-lesional skin. The rarity of the concurrence of these 2 diseases in the same patient and the discriminating findings with tissue typing analysis suggest that this coexistence may be coincidental.

Adult↗

PubMedDate not supplied

Systemic lupus erythematosus in the younger patient: survival studies.

One hundred eighty-two patients fulfilling the American Rheumatism Association criteria for the classification of systemic lupus erythematosus (SLE) were followed prospectively. Sixty-seven had the onset of SLE before age 21, 32 before age 16, and 35 between age 16 and 20. All patients received similar therapy. Only 4 patients received cytotoxic agents. Malar blush, cellular casts, and profuse proteinuria were significantly more common in the 0-15 compared to the adult group (age 21 or older). Five-year survival was 100% for children with membranous or focal lupus nephritis and 85% for diffuse proliferative lupus nephritis.

Adolescent↗

PubMedDate not supplied

Lyme disease.

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Diagnosis, Differential↗