Biomedical subjects

A Wedrich

Publications and source records attributed to A Wedrich.

48 records · Page 3Linked to original sources

PubMed1992

Effect of carbachol on intraocular pressure in small-incision cataract surgery.

Sixty patients, who underwent phacoemulsification and implantation of a folded polyHema intraocular lens were assigned to two groups. Following wound closure 0.5 ml of 0.01% carbachol or balanced salt solution was instilled into the anterior chamber. Healon was used in all eyes but evacuated from the capsular bag behind the intraocular lens and the anterior chamber. Intraocular pressure was measured the day before as well as 6 and 18 hours postoperatively. At 6 hours the mean change of intraocular pressure from baseline was -2.8 +/- 5.3 mmHg in the carbachol group compared with +4.7 +/- 8.0 mmHg in the BSS group (p < 0.0001). At 18 hours the mean change from baseline was -3.0 +/- 4.6 mmHg in the treatment group and +2.3 +/- 8.5 in the control group (p < 0.0001). Intraocular pressure exceeding 25 mmHg at 6 hours was observed in 8 (27%) eyes of the control group but none of the treatment group. At 18 hours 4 (13%) eyes of the control group and 1 (3%) of the carbachol group still had an increase of intraocular pressure. Summarizing our results we conclude that the effect of Healon on the postoperative intraocular pressure is successfully counteracted by its aspiration from the capsular bag and the anterior chamber, especially when carbachol is used for intraoperative miosis.

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PubMed1992

Induced astigmatism following small incision cataract surgery combined with trabeculectomy.

The combination of phacoemulsification and implantation of foldable intraocular lenses through a small incision with a trabeculectomy is increasingly preferred in glaucoma patients with coexisting cataract. Small incisions induce less astigmatism and thereby enhance visual recovery. This study should clarify if this benefit of small incision cataract surgery is preserved when combined with a trabeculectomy. Thirty-five eyes were included in this study. Preoperative astigmatism measurements were compared with those obtained one month and one year postoperatively. Vector analysis was performed. A series of 30 cases which underwent small incision cataract surgery alone were used as a control group. One month postoperatively the eyes undergoing the combined procedure showed about the same with-the-rule astigmatic peak (mean: +0.32 dpt.) as the control group eyes (mean: +0.26 dpt.; p > 0.05). One year postoperatively both groups showed the same against-the-rule astigmatic shift (mean: -0.28 dpt.; p > 0.05). In conclusion, patients undergoing small incision cataract surgery combined with trabeculectomy showed a small amount of surgically induced astigmatism. When compared with patients which underwent small incision cataract surgery alone, the difference in astigmatic changes was found to be statistically not significant.

Astigmatism↗

PubMed1992

Combined small-incision cataract surgery and trabeculectomy--technique and results.

In a prospective study 35 eyes of 25 patients with coexisting cataract and glaucoma underwent trabeculectomy, phacoemulsification and implantation of a folded polyHema intraocular lens through the trabeculectomy opening. Follow-up ranged from 6 to 27 months (mean 13.3). The mean age was 76.4 (68 to 88 years). 22 eyes suffered from primary open angle glaucoma, 10 eyes from a pseudoexfoliation glaucoma and 3 eyes had a chronic angle closure glaucoma. Preoperatively intraocular pressure was controlled in 10 eyes with a mean medication of 2.1 but uncontrolled in 25 eyes (mean medication: 2.5). The preoperative visual acuity ranged from 20/40 to hand motions. Postoperatively intraocular pressure was controlled (< 18 mmHg) in all (100%) eyes and without therapy in 32 (91%) eyes. Three (9%) eyes had to be treated with topical timolol twice a day after surgery. Mean intraocular pressure dropped from 21.2 +/- 6.0 mmHg preoperatively to 13.5 +/- 2.1 mmHg postoperatively. Vision improved in all but 4 eyes, 25 (74%) achieving a visual acuity of 20/40 or better. The causes for failed improvement or deterioration of vision were senile macular degeneration in 2 eyes and central retinal vein occlusion and vascular optic nerve atrophy in one eye respectively. Post-operative complications included hyphema in 9 (26%) eyes, fibrin effusion to a various extent into the anterior chamber in 19 (54%) eyes and delayed hypotony (< 5 mmHg) with chorioidal effusion in 1 (3%) eye. Fibrin effusion was frequently observed in eyes with intraocular pressure below 10 mmHg, iris surgery and hyphema. Finally the complications did not effect the results regarding visual acuity or glaucoma control.(ABSTRACT TRUNCATED AT 250 WORDS)

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PubMed1992

Intraocular pressure following small-incision cataract surgery and polyHEMA posterior chamber lens implantation. A comparison between acetylcholine and carbachol.

Ninety patients who had phacoemulsification and implantation of a flexible polyHEMA intraocular lens (IOGEL 1103) were assigned to three groups. After evacuation of sodium hyaluronate retrolentally from the capsular bag, 0.5 ml of 1% acetylcholine chloride, 0.01% carbachol, or balanced salt solution was instilled into the anterior chamber following wound closure. Intraocular pressure (IOP) was measured the day before, and six hours, 18 hours, and one week postoperatively. No topical or systemic antiglaucomatous drug was given during the study period. Preoperatively and one week postoperatively there was no significant difference between the three groups (P greater than .01). At six hours postoperatively the mean IOP decreased in the carbachol group (-2.8 mm Hg) and increased in the acetylcholine and control groups (+0.6 mm Hg and +/- 4.7 mm Hg) when compared with baseline pressures. At 18 hours the mean change from baseline was -3.0 mm Hg in the carbachol group, +0.8 mm Hg in the acetylcholine group, and +2.3 mm Hg in the control group. At six hours IOP exceeding 22 mm Hg was observed in ten of the control patients (30%) receiving balanced salt solution intracamerally and four of the acetylcholine patients (13.3%) but none of the carbachol patients. At 18 hours IOP remained above 22 mm Hg in three of the acetylcholine patients (10%) and four of the control patients (13.3%). Only one of the carbachol patients developed an increase of IOP up to 26 mm Hg at 18 hours. Removal of viscoelastic substances from behind the IOL reduced the incidence of pressure spikes in the early postoperative period.(ABSTRACT TRUNCATED AT 250 WORDS)

Acetylcholine↗

PubMed1992

[Effect of intraocular administration of acetylcholine and carbachol on postoperative intraocular pressure after cataract surgery].

In a consecutive series of 90 patients we examined the effect of intracameral acetylcholine and carbachol on intraocular pressure following extracapsular cataract surgery. In all cases phacoemulsification and implantation of a folded polyhema intraocular lens under healon was performed. After evacuation of the viscoelastic substance from the capsular bag behind the inserted lens and wound suturing we instilled 0.5 ml 1% acetylcholine, 0.5 ml 0.01% carbachol or 0.5 ml balanced salt solution respectively into the anterior chamber. Without the influence of antiglaucomatous drugs applanation tonometry was performed 6 and 18 hours postoperatively. When compared with preoperative values intraocular pressure decreased in the carbachol group (-2.8 mm Hg) but increased in the acetylcholine group (+0.6 mm Hg) and control group (+4.7 mm Hg). 18 hours postoperatively the mean change was -3.0 mm Hg in the carbachol group, +0.8 mm Hg in the acetylcholine group and +2.3 mm Hg in the control group. Intraocular pressure exceeding 22 mm Hg at 6 hours was observed in 33% of the control group and 13% of the acetylcholine group but none of the carbachol group. At 18 hours intraocular pressure was still elevated in 13% of the control group, 10% of the acetylcholine group and 3% of the carbachol group. Reviewing our results we conclude that the evacuation of viscoelastic substances from the capsular bag behind the implanted lens reduces the incidence of pressure rises in the early postoperative period. This effect can be enhanced by the use of acetylcholine and, the more potent, carbachol.

Acetylcholine↗

PubMed1992

Effect of acetylcholine on intraocular pressure following small-incision cataract surgery.

40 patients, who underwent phacoemulsification and implantation of a polyHema intraocular lens (IOGEL-1103) were assigned to two groups. After evacuation of Healon from the capsular bag behind the lens and the anterior chamber, either 0.5 ml of 1% acetylcholine chloride or 0.5 ml of balanced salt solution was injected into the anterior chamber. When compared with preoperative values, the mean intraocular pressure (IOP) 6 h postoperatively was unchanged in the acetylcholine group (0 +/- 8.5 mm Hg) but increased in the control group (+4.1 +/- 7.4 mm Hg). 18 h postoperatively, the mean intraocular pressure slightly decreased in the acetylcholine group (-0.5 +/- 6.1 mm Hg) compared with an increase of +1.4 +/- 4.4 mm Hg in the control group. Intraocular pressure exceeding 25 mm Hg was observed at 6 h in 2 (10%) patients of the acetylcholine group and in 4 (20%) of the control group. At 18 h, intraocular pressure was elevated in only 1 (5%) patient of the acetylcholine group and in 3 (15%) of the control group. From these results, we conclude that the evacuation of Healon from the capsular bag behind the implanted lens and acetylcholine reduce the incidence of postoperative elevations of intraocular pressure.

Acetylcholine↗

PubMed1990

Evaluation of 150 consecutive cases of poly HEMA posterior chamber lenses implanted in the bag using a small-incision technique.

We report the results of 150 capsular bag implantations of the IOGEL PC-12 hydrogel lens. Mean follow-up was seven months. Following capsulorhexis and phacoemulsification, a Faulkner folder was used to insert the lens through a 3.5 mm to 4.0 mm scleral tunnel incision. Initially, a number of surgical complications were encountered. Because of increasing experience and modified instrumentation and technique, these did not occur in the later cases. Visual results were good, all eyes gaining a best case visual acuity of 20/40 or better and 97% achieving 20/25 or better. Morphological results were satisfactory. Generally the lenses remained centered and at a distance from the iris. Retention of viscoelastic substance or debris between the lens and the posterior capsule, occasionally observed at the start of the series, has been avoided by retrolental aspiration. Persistent pigment dispersion, which was observed when the lens had been implanted in the sulcus, was not seen. Tolerance of the lens material was generally satisfactory. There were six cases (4%) of fibrinoid uveitis, which is a relatively high incidence. From our experience and results we conclude that this implantation procedure allowed controlled insertion and placement of the IOGEL lens, provided that adequate instrumentation and technique was used; visual performance was comparable to that of poly(methyl methacrylate) lenses; capsular bag fixation furnished satisfactory morphological results, provided an adequately shaped capsulorhexis was performed.

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PubMed1990

Long-term follow-up of argon laser trabeculoplasty in uncontrolled primary open-angle glaucoma. A study with standardized extensive preoperative treatment.

The long-term results of 180 degrees argon laser trabeculoplasty (ALT) were studied in 61 eyes of 43 patients with uncontrolled primary open-angle glaucoma [intraocular pressure (IOP) less than 22 mm Hg]. In order to enhance the relevance of this prospective study, only eyes that had not responded to medication despite standardized extensive therapy were followed up over an average period of 4.4 years [52.8 +/- 7.3 (mean +/- SD) months]. The success rate of treatment (decrease in IOP less than 5 mm Hg, IOP below 20 mm Hg, stable visual field, stable optic nerve head and no further laser or surgical intervention) after 4.4 years was 73.7%. The mean decrease in IOP was 8.5 +/- 2.9 mm Hg (mean +/- SD). Eyes receiving ALT before cataract surgery retained control of IOP after surgery. A comparable pressure control was also attained with those eyes that had undergone previous trabeculectomy. Failures (26.3%) all occurred in the 1st year after treatment. The results and conclusions from our study are compared with those reported in the literature. The different theories regarding the mechanisms of action of ALT are discussed.

Adult↗

PubMedDate not supplied

Comparison of results and complications following combined ECCE-trabeculectomy versus small-incision-trabeculectomy and posterior chamber lens implantation.

PURPOSE: To compare the efficacy and complication rate of two standard cataract extraction techniques with different incision lengths when combined with trabeculectomy. METHODS: 54 eyes after combined ECCE, posterior chamber lens implantation and trabeculectomy (ECCE-group) are compared with 49 eyes following phacoemulsification, trabeculectomy and implantation of a folded flexible posterior chamber lens (small-incision group). Minimum follow-up was 24 months. RESULTS: Glaucoma control was achieved in all eyes of both groups. There was a tendency towards a higher number of patients without therapy in the small-incision group (82% versus 65%, p = 0.07). Final mean IOP (14.2 +/- 3.0 mmHg versus 15.5 +/- 2.7 mmHg, p = 0.02) and mean therapy index (0.2 +/- 0.5 versus 0.4 +/- 0.6, p = 0.03) were significantly lower in the small-incision group. Postoperative complications such as severe fibrin effusion (41% versus 18%, p = 0.018), early postoperative IOP rises > 25 mmHg (18% versus 2%, p = 0.009), filtering bleb scarring (63% versus 8%, p < 0.0001) and the total number of complications (87% versus 63%, p = 0.006) were significantly higher in the ECCE-group. CONCLUSION: With the decrease of the incision size necessary for the cataract extraction a reduction of postoperative complications and better functional results are achieved in combined cataract/glaucoma surgery.

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PubMedDate not supplied

The use of recombinant tissue plasminogen activator for intracameral fibrinolysis following cataract surgery.

In a prospective study performed between June 1992 and March 1994 19 eyes of 19 patients with dense fibrinous pupillary membranes following cataract surgery were treated with intracameral injections of 25 micrograms recombinant tissue plasminogen activator (r-tPA). Injections were performed between the second and twenty-third postoperative day (mean 5.6 +/- 6.9 days). Complete fibrinolysis within one to 4 hours (mean: 3.3 +/- 0.89 hours) was observed in 18 (94.7%) eyes. In one (5.3%) eye fibrinolysis was incomplete despite a second injection. In 2 (10.5%) eyes. No recurrence of a distinct fibrinous membrane was noted which then cleared spontaneously with topical treatment. A small hyphema developed in 2 (10.5%) eyes and intraocular pressure exceeded 25 mmHg in 2 (10.5%) eyes. No increase of keratopathy nor any toxic intraocular side effect of 25 micrograms intracameral r-tPA was observed throughout the study. The intracameral injection of r-tPA clinically proved to safely accelerate the resorption of dense fibrinous membranes following cataract surgery and thus enhance visual recovery minimizing subsequent complications and systemic or subconjunctival anti-inflammatory treatment.

Adult↗

PubMedDate not supplied

Intracameral tissue plasminogen activator to treat severe fibrinous effusion after cataract surgery.

PURPOSE: To evaluate the efficacy and complications of intracameral recombinant tissue plasminogen activator (r-tPA) in the treatment of severe fibrinous effusion after cataract and combined cataract and glaucoma surgery. SETTING: University Eye Hospital Vienna, Austria. METHODS: In a prospective study, 40 eyes of 39 patients with severe fibrinous anterior chamber reaction in the early postoperative course received 25 microg r-tPA intracamerally through a temporal paracentesis. The main outcome measures were rate of complete fibrinolysis, time of maximal effect, and complications. RESULTS: Complete fibrinolysis occurred in 33 eyes (83%) after a mean of 3.2 hours +/- 0.9 (SD). The rate of complete fibrinolysis was higher in eyes having cataract surgery only (24 eyes, 89%) than in those having combined surgery (9 eyes, 69%). Recurrent fibrin was seen in 3 eyes (7%), small anterior chamber hemorrhage in 7 (18%), increased intraocular pressure in 3 (7%), and posterior synechias in 13 (33%). Complications were managed conservatively. CONCLUSION: The intracameral injection of 25 microg r-tPA proved to be a safe, efficient, and low-risk supplement in the treatment of severe postoperative fibrinous reactions.

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PubMedDate not supplied

Midterm visual outcome and progression of diabetic retinopathy following cataract surgery. Midterm outcome of cataract surgery in diabetes.

OBJECTIVE: To assess the influence of cataract surgery on progression of diabetic retinopathy and visual acuity. METHODS: 37 patient eyes with mild to moderate diabetic retinopathy at baseline underwent phacoemulsification and intraocular posterior chamber lens implantation. They were examined 3.3 +/- (SD) 0.7 years after surgery. RESULTS: 83.8% of the eyes showed a better final visual acuity, and 67.6% achieved a final visual acuity of 0.5 or better. The retinopathy remained unchanged in 83.8% and progressed in 16.2% of the eyes. No eye progressed to proliferative retinopathy. CONCLUSION: Phacoemulsification and implantation of a posterior chamber intraocular lens is a safe procedure for patients with mild to moderate diabetic retinopathy.

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