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Biomedical subjects

A Warnke

Publications and source records attributed to A Warnke.

69 records · Page 4Linked to original sources
PubMed1994

Childhood-onset schizophrenia: history of the concept and recent studies.

Schizophrenic disorders in childhood are rare: 0.1-1 percent of all schizophrenic disorders manifest themselves before age 10, and 4 percent before age 15. There is, however, a remarkable increase in schizophrenia during adolescence. Age and developmental stage also influence symptoms, course, and outcome. The evidence for a male preponderance in the very early-onset group (< 14) does not apply for adolescents over age 14. The presence of positive and negative precursor symptoms can be demonstrated in child and adolescent schizophrenia before the first clinical manifestation leading to inpatient treatment. With regard to pharmacologic treatment, atypical neuroleptics such as clozapine can be used successfully. As to outcome, schizophrenic psychoses with early manifestation have a poor prognosis. The patients' premorbid personality also seems to be of great importance: A poor prognosis can be found in patients who were cognitively impaired, shy, introverted, and withdrawn before the beginning of their psychotic state.

Adolescent↗
PubMed1994

[Bone density in anorexia nervosa--with comments on prevention and therapy of osteoporosis].

Anorectic women often have reduced bone density, which may predispose them to osteoporosis and fractures. The mechanisms involved and their relative contribution are still a matter of discussion. Most studies have been done in young adults, but during the past few years children and adolescents have also been investigated. In this paper we present preliminary data on bone mineral parameters in young anorectic females during the first few months of inpatient treatment. Measurement of trabecular bone density (TBD), bone mineral density (BMD) and body composition were done by peripheral quantitative computed tomography (pQCT) at the distal end of the radius and by dual-energy X-ray absorptiometry (DEXA) in ap-projection. Hormonal parameters and clinical course were monitored. Baseline values of TBD and BMD seemed to be generally within the normal range. Follow-up measurements showed a significant reduction in TBD but not in BMD in most patients during the first two months of treatment despite clinical improvement. There was no clear correlation with hormonal or clinical parameters. Further evaluations are necessary. Possible therapeutic consequences are discussed.

Adolescent↗
PubMed1990

[Concept and services provided by a mobile pediatric and adolescent psychiatric service in a rural area].

A mobile child and youth psychiatric service is presented that concerned with the mental health care of a county with a population of 239,000 inhabitants. This kind of service was conceived especially to meet the demands of rural regions which are high, as empirical investigations about administrative and real prevalence have shown. The hypothesis that child and youth psychiatric or other specialized institutions create demands not normally existing, could be refuted. The service proved to be an efficient model for mental health care in rural regions so that it can be looked upon--especially in areas which are not sufficiently provided with child psychiatric institutions--as a fully valid alternative to other kinds of mental health services. Still, there is the problem of financing, which is not yet completely solved. A standardized regulation for the whole Federal Republic is suggested with the participation of the health insurance funds.

Adolescent↗
PubMed1989

Variability of immunoglobulin expression in follicular lymphoma. An immunohistologic and molecular genetic study.

Immunohistochemical and molecular genetic studies were performed on tissues involved by follicular lymphomas that at some point in their course showed a lack of detectable surface or cytoplasmic immunoglobulins (Ig). The variable nature of Ig expression in these lymphomas was evidenced by three tumors biopsied from two different sites that showed an Ig-negative phenotype in one biopsy versus an Ig-positive phenotype in the other. The B lineage derivation of Ig-negative follicular lymphomas was confirmed by the presence of Ig heavy and light chain gene rearrangements in eight of eight lymphomas tested. In a way similar to Ig-expressing follicular lymphomas, the Ig-negative tumors were characterized by bcl-2 gene rearrangements (seven of eight) and overexpression of the Bcl-2 protein (eight out of nine). In two of the three lymphomas with Ig-positive and Ig-negative tumor cell populations, the clonal relationship of the Ig-expressing and nonexpressing cells was established by demonstration of identical t(14; 18) DNA rearrangements. The findings demonstrated that the variability of Ig expression in follicular lymphomas reflects the phenotypic heterogeneity of these tumors and is not a manifestation of separate clonal origins.

Gene Rearrangement↗
PubMed1987

[Treatment of dyslexia in childhood].

Dyslexia often causes failure at school, emotional problems in children and affects the occupational career of the adult. Early treatment is important, it includes: a) individual treatment of reading and writing performance by means of functional training and learning behavior management, b) strengthening the child's psychological ability by psychotherapy to handle the persisting handicap more successfully, c) special education at school and support of the family. Therapeutical efforts should be combined and integrated. Dyslexia tends to persist. As few as about 4% of severely disabled readers seem to attain normal reading level during high school. Treatment improves prognosis concerning educational and occupational career.

Combined Modality Therapy↗
PubMed1981

[Etiology of behavior disorders in children: a study of children in inpatient psychiatric treatment (author's transl)].

The behavior problems of 144 behaviorally disturbed children are described who were treated as inpatients between 1966 and 1973. The problems were classified with the multiaxial classification system for psychiatric disorders in childhood. In addition, they were evaluated with a psychopathology assessment inventory developed by the authors. Data on somatic and psychosocial factors were also recorded. Specific behavior disorders were associated with specific somatic and psychosocial factors. The extent to which behavior could be modified during in patient treatment depended on the kind and severity of the behavior problems bu only to a small extent on somatic and psychosocial factors. On the other hand, parenteral cooperativeness had a significant influence on therapeutic outcome. The multiaxial classification system was validated by the ratings on the psychopathology assessment inventory. The reasons for certain difficulties in classifying behavior problems in children are discussed.

Adolescent↗
PubMedDate not supplied

Dermatologic findings in anorexia and bulimia nervosa of childhood and adolescence.

The cutaneous signs of anorexia nervosa (AN) and bulimia nervosa (BN) have been described previously in adult patients. For the first time, we present here dermatologic findings in children and adolescents suffering from eating disorders. Thirty consecutive young anorexic and bulimic inpatients (8 to 17 years of age, mean 15.1 years) underwent a standardized dermatologic examination. Patients were checked for abnormalities of the skin including atopic stigmata, dermographism, hair, nails, and oral cavity. Serum was obtained for hemoglobin, iron, zinc, GPT, thyroid, and sex-hormone levels. In 13 patients, the total serum IgE was determined, and a prick test was carried out with defined type I allergens. Findings in order of frequency included xerosis of the skin, white dermographism, diffuse hypertrichosis, acrocyanosis, scars, diffuse effluvium, artifacts, brittle nails, and onychophagia. Significant co-relations were found between the presence of hypertrichosis and the existence of amenorrhea or a body mass index of less than 16. In 22 patients a low T3 level was found. In summary, children and adolescents suffering from AN or BN show dermatologic features similar to those reported in older patients. Special findings in this age group are extensive lanugo hair and signs of autoaggressive behavior.

Adolescent↗