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Biomedical subjects

A Warnet

Publications and source records attributed to A Warnet.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Acromegaly].

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Acromegaly↗
PubMed1987

The effect of subcutaneous infusion versus subcutaneous injections of a somatostatin analogue (SMS 201-995) on the diurnal GH profile in acromegaly.

Multiple sc injections of a long-acting somatostatin analogue (SMS 201-995) are currently used in the treatment of acromegaly. However, plasma GH concentration often reaches a pathological level (less than 5 micrograms/l) between two injections. In seven patients with active acromegaly we compared, in a short-term trial, the effect of SMS 201-995 administered by continuous sc infusion (50 micrograms and 100 micrograms a day) and by three sc injections (100 micrograms each). In six patients, plasma GH levels were significantly reduced regardless of the mode and dose of treatment (P less than 0.05). However, comparing diurnal profiles, 100 micrograms continuous sc infusion was more effective than discontinuous administration in reducing the number of GH levels above 5 micrograms/l (P less than 0.01). In two patients, continuous infusion was the only way to decrease all plasma GH values below 5 micrograms/l during the diurnal profile determination. Moreover, even when, in a long-term study, the dose of multiple injections was progressively increased to 500 micrograms three times a day, GH levels remained consistently elevated in one of these patients. Thus, in some acromegalic patients continuous sc injection seems currently the most efficient way of treatment with SMS 201-995.

Acromegaly↗
PubMed1986

[Thyrotropic function in patients with a hypothalamic or pituitary tumor. Possibility of the secretion of a TSH with reduced biological activity].

Thyrotropic function was studied in 100 patients with hypothalamic or pituitary tumours before treatment. Eighteen patients with thyroid deficiency showed no signs of primary hypothyroidism. This was also showed in 4 other hypothyroid patients who had pituitary tumours studied later on. Only 4 of these 22 patients had TSH deficiency. The other 18 had normal or high plasma TSH levels, and the TSH response to TRH was normal but often delayed and/or prolonged. This pattern, suggestive of secretion of TSH with reduced biological activity, might however be due to other factors. Tumoral invasion of the hypothalamus, present in these 18 cases, could reduce secretion of TRH and dopamine. Hypothyroidism would then be secondary to TRH deficiency if TRH is considered to have a direct thyroid-stimulating action, and, like dopamine deficiency, could contribute to maintaining normal or high TSH secretion.

Adenoma↗
PubMed1985

Hemostasis disorders in diabetes mellitus.

Hemostasis disorders are involved in diabetic micro and macroangiopathy. Platelet hyperactivity is related at least in part to an imbalance between thromboxane A2 and prostacyclin. Both hyper and hypoglycemia result in platelet activation.

Animals↗
PubMed1983

[Inhibin and cyberning].

Inhibin is a peptidic gonadal hormone which preferentially suppresses FSh secretion and synthesis. As its purification is not yet achieved, only bioassays are available, performed with testicular extracts or follicular fluid. Its secretion by granulosa cells and Sertoli cells is partly spontaneous, partly stimulated by androgens and FSH. In women, folliculogenesis is controlled by inhibin induced FSH fluctuations. But inhibin acts also at the gonadal level like the cybernis, peptidic substances secreted by the ovary, which modulate ovarian effects of gonadotrophins. Five of them have been identified : the oocyte maturation inhibitor, the luteinization inhibitor, the FSH binding inhibitor (implied in follicular atresia), the LH receptor binding inhibitor (involved in luteolysis), and gonadocrinins (which bind to ovarian LHRH-receptors). The discovery of these ovarian peptides leads to new concepts in folliculogenesis and luteolysis and may provide a new therapeutic approach in contraception and sterility fields.

Animals↗