[Effect of dose rate on intestinal tolerance in mice. Implications in radiotherapy (author's transl)].
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to A Wambersie.
Explore the source record for details and available documents.
The rate of reciprocal translocations induced in mouse spermatogonia by exposure to X-rays and to neutrons produced by 16 and 50 MeV deuterons has been estimated by scoring multivalent configurations in the descendant spermatocytes. In the X-irradiated group the yield of translocations increases from 2,1 per 100 cells after exposure to 100 rad to 5,7 after exposure to 300 rad. The dose-response relationship shows no statistical departure from linearity. After exposure to 50, 100 or 150 rad of d (16) + Be and d (50) + Be neutrons, the yield of translocations displays a humped curve. Up to this dose the RBE value decreases with absorbed dose and neutron energy.
Explore the source record for details and available documents.
A clinical study of human skin desquamation has provided the variation of the isoeffect curve as a function of the fraction number and overall time. These results have been compared to ELLIS formula (N.S.D.). These results have been compared to relationships related to intestinal mucosa and lung. Differential effects are put in evidence between these tissues as a function of fractionation and overall time. Such differential effects are likely to exist between tumors and normal tissues; however the basic data are still missing for optimizing the time factors of the therapeutic irradiations.
The incidence of reciprocal translocations induced in mouse spermatogonia has been studied in CBA mice given X-ray or neutron exposure. Analysis of dividing spermatocytes at diakinesis-first metaphase stage of meiosis shows that in X-irradiated mice there is a linear dose-response relationship. After exposure to fast neutrons the yield of translocations follows a humped curve with a maximum of chromosome exchanges after exposure to 100 rad.
The physical and radiobiological experiments performed with the fast neutron beams at the cyclotron of the University of Louvain are described and discussed in view of their therapeutic applications.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.