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Biomedical subjects

A Wallgren

Publications and source records attributed to A Wallgren.

At least 91 records · Page 5Linked to original sources
PubMed1979

Prognistic relevance of radiation induced immune suppression in breast carcinoma.

The extent of radiation induced immune suppression was analysed in 100 patients with carcinoma of the breast. The relative changes of lymphocyte counts and stimulations by PHA and PPD were similar in patients who differed with regard to age, size of tumour and its malignancy grade or axillary node condition. Moreover, no difference in the degree of radiation induced immune suppression existed between patients who developed recurrent disease and those who remained free of disease during a follow-up period of 4 1/2 to 7 years.

Breast Neoplasms↗
PubMed1979

Blood lymphocyte subpopulations in breast cancer patients following post-operative adjuvant chemotherapy or radiotherapy.

The peripheral lymphocyte population was examined in sixty-five randomized breast cancer patients before and after post-operative adjuvant cyclic chemotherapy or local radiation therapy. During 10 months of chemotherapy total lymphocyte and T cell counts were reduced to 70% and non-T cells to about 50% of pretreatment values. The population of T cells was unaltered whereas the proportion of non-T cells was significantly reduced at the end of the period. Immediately after radiotherapy total lymphocyte and T cell counts were reduced to 30%, and non-T cells to 15% of pretreatment values. During 10 months' observation total lymphocyte and T cell counts increased to 70%, and non-T cells to 50--60% of pretreatment values.

Animals↗
PubMed1978

Preoperative radiotherapy in operable breast cancer: results in the Stockholm Breast Cancer Trial.

A randomized trial of preoperative radiotherapy in operable breast cancer was conducted from 1971 to 1976. The diagnosis was established by fine-needle aspiration biopsy. A dose of 4500 rad over five weeks was given to the chest wall, the breast and the lymph nodes of the axilla, the supraclavicular fossa and the internal mammary chain. Modified radical mastectomy was performed six weeks or more after completed radiotherapy. In control patients the same operation was performed without prior radiotherapy. By random allocation, one control group received no further treatment and postoperative irradiation was given to the other controls. Preoperative radiotherapy reduced the incidence of local and regional recurrence and of distant metastases, and also the mortality, as compared with the surgery only group. Postoperative radiotherapy as given in this trial gave almost equal reduction of local and regional recurrence but did not diminish the frequency of distant metastases or the mortality.

Adult↗
PubMed1978

Carcinoembryonic antigen and other tumor markers in tissue and serum or plasma of patients with primary mammary carcinoma.

50 patients with primary breast cancer were studied to determine the CEA and HCG contents in their tumor cells before any treatment was initiated. Tumor cells were obtained by needle biopsy and each tumor cell population was stained by immunofluorescence. In 21 of the 50 patients, CEA containing cells were found in a frequency ranging from 5 to 80% of the tumor cell population. The results were confirmed by radioimmunoassay of tumor extracts. No apparent relation was seen to cytologic type or grade of differentiation. HCG was detected by IF in 4 tumors with an apocrine cytologic cell type. The level of CEA in plasma was determined before treatment and followed for 2-6 months in 72 patients. CEA was the only measured serum parameter that correlated initially with size and extent of the localized tumor. It was too low to be of use for monitoring primary disease, but should be of value in early detection of metastasis. Posttreatment a low or decreased plasma CEA was seen more often in patients who had had curative treatment than in those given palliative radiation. No raised serum HCG levels were found. Raised serum liver enzymes did not predict the extent of the primary tumor but may be an indication of distant spread. Tumor CEA content and CEA plasma concentration were correlated, although not very strongly. This means that CEA, although present in the tumor, is not always released in measurable amounts.

Alkaline Phosphatase↗
PubMed1977

Carcinoma of the breast in women under 30 years of age: a clinical and histopathological study of all cases reported as carcinoma to the Swedish Cancer Registry, 1958-1968.

During 1958, 91 cases of breast carcinoma in women below 30 years of age were reported to the Swedish Cancer Registry. A histologic reexamination showed that 16 of these women had only benign proliferative conditions. Among the remaining 75 patients, two had noninvasive carcinoma, eight advanced carcinoma, and 65 operable invasive carcinoma. The carcinomas were characterized by little fibrous stroma and little or no elastosis. The survival rate of the patients with invasive breast carcinomas was similar to that in a total geographic material of all ages with breast carcinoma. The carcinoma was treated during pregnancy or within 1 year after delivery in 15 patients, with the same survival rate as for those whose carcinoma was not complicated by pregnancy.

Adolescent↗
PubMed1977

[The Stockholm preoperative radiotherapy of operable breast cancer. Preliminary report].

The 4 year results of a prospective clinical trial on the treatment of operable breast cancer, comparing the effects of preoperative radiotherapy followed by surgery with those of surgery followed or not by postoperative radiotherapy are presented for patient groups of approximately 100 each. At 4 years 85 per cent survive after preoperative radiotherapy plus surgery, as against 77 per cent after surgery only and 81 per cent after surgery plus postoperative radiotherapy. These differences are not statistically significant. The incidence of local recurrence after radiotherapy was reduced to 1/4 of that seen after surgery only. The radiation could be shown to induce temporary damage in a number of immunological parameters. No correlation could be demonstrated between these findings and the clinical course of the disease.

Breast Neoplasms↗
PubMed1976

Prognostic factors in mammary carcinoma.

The simultaneous prognostic influence of multiple clinical and microscopic features of mammary carcinoma was analysed in 581 women with radical mastectomy. The most important of these features were connected with the extent of the disease in the axillary lymph nodes. In substantial groups of patients, however, a favourable outcome could be predicted from microscopic features of the primary tumour, viz. tubule formation, mitotic frequency and elastosis.

Adult↗
PubMed1974

Bone-mineral losses in oophorectomized women.

The bone-mineral content of oophorectomized and non-oophorectomized women was assayed by x-ray spectrophotometry in five different parts of the skeleton. The patients had previously been treated for mammary cancer and were clinically free from disease. In the five to ten-year postoperative period the oophorectomized women had significantly lower mineral content in mainly trabecular parts of the skeleton (average, -18 per cent; p less than 0.01), whereas the mineral content in cortical parts of the skeleton was not significantly lower (average, -7 per cent; p greater than 0.01). The mineral loss in axial and peripheral trabecular bone was of the same magnitude. The results indicate that cessation of ovarian function will lead to an increased fracture risk in the wrist and the femoral neck, as well as in the spine.

Adult↗