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Biomedical subjects

A Walan

Publications and source records attributed to A Walan.

At least 91 records · Page 5Linked to original sources
PubMed1977

Influence of food on the effect of propantheline and L-hyoscyamine on salivation.

The absorption of a quartenary (propantheline, 30 mg) and a tetiary (1-hyoscyamine, 0.8 mg) anticholinergic compound was studied in 8 healthy volunteers by measuring the effects on salivation. Both compounds were administered as rapidly disintegrating tablets, 1-hyoscyamine also in a slow-release formulation (Egazil Durules). The three preparations and placebo were administered under fasting conditions and with a standardized light meal using a randomized cross-over design. Salivation measurement were performed with a citric acid stimulation method every hour for 10 hours. In the fasting patient, all three anticholinergic test preparations decreased the salivation significantly. When taken with food, the effect of propantheline was almost abolished, while the effects of the 1-hyoscyamine preparations were uninfluenced. It was concluded that the clinical effects of proprantheline might be extremely varying depending how the drug is taken in relation to meals. In contrast the clinical effects of 1-hyoscyamine seem to be independent of food intake.

Adolescent↗
PubMed1976

Cimetidine in the treatment of active duodenal and prepyloric ulcers.

44 patients with endoscopically confirmed duodenal (36) or prepyloric (8) ulcers have received in a double-blind trial either the histamine H2-receptor antagonist cimetidine (30 patients) or placebo (14 patients) for six weeks. At three weeks 67% of patients treated with cimetidine and 17% of those receiving placebo had endoscopically healed ulcers (chi2 = 8.49; P less than 0.005). At six weeks all except 3 patients receiving cimetidine (90%) had healed ulcers compared with 36% receiving placebo (chi2 = 11.11; P less than 0.001). Those receiving cimetidine had less daytime and nocturnal pain than patients on placebo. The differences were statistically significant for daytime pain during four of six weeks. The cimetidine-treated patients consumed significantly less antacids than placebo-treated patients and these patients' overall assessments of their wellbeing were significantly better. All patients on cimetidine had a significant reduction (P less than 0.0005) of their basal and pentagastrin-stimulated acid secretion, but no reduction in acid secretion was measured in the group who received placebo.

Adult↗
PubMed1975

In vivo studies on the neutralizing effect of antacids using the Heidelberg capsule.

The effects on gastric pH of various forms of administration of antacids have been studied in healthy volunteers. Gastric pH was recorded using a radiotelemetric technique (Heidelberg Capsules). In one series of experiments the Heidelberg Capsules were compared with a conventional aspiration method of measuring gastric pHqt lower pH-levels (pH smaller than 2) the Heidelberg Capsules recorded lower values than what was found with the aspiration technique. However, when the pH-response to an antacid dose was studied the two techniques gave concordant results. In another series of experiments, four antacids with the same acid-neutralizing capacity in vitro were compared in fasting subjects, using a crossover design. A liquid preparation and a chewable tablet gave almost equal results with a short latency time and a duration of action of more than one hour (mean 69 minutes and 82 minutes, respectively, with pH above the basal level). Two other tablet antacids designed to be swallowed whole gave less prompt effects and a shorter duration of action (mean 45 minutes for both, with pH above the basal level).

Adult↗