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Biomedical subjects

A Wajgt

Publications and source records attributed to A Wajgt.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Local production of oligoclonal immunoglobulin in the central nervous system in multiple sclerosis in the light of quantitative and qualitative studies of cerebrospinal fluid immunoglobins].

The paper contains the results of qualitative and quantitative immunoglobulin (Ig) determinations in the cerebrospinal fluid (CSF) in multiple sclerosis (m.s.) and their evaluation in the aspect of the significance of local production and oligoclonal character of Ig in the pathogenesis of m.s. A statistically significant rise was found in the absolute and relative levels of IgG and IgA with an evident rise in the IgM level and IgG ratio values. The oligoclonal character of CSF Ig in electrophoresis in agar or agarose was evident in 84% of m.s. cases, and also in a limited number of cases of other central nervous system diseases. Abnormal ratio of kappa/lambda light globulin chains was found exclusively in investigations of CSF from m.s. cases--in 52% of cases, and in one case of subacute sclerosing panencephalitis. The author concludes that in most m.s. cases local production of oligoclonal Ig takes place within the CNS, but the mechanisms determining local selection of a limited number of cell clones in this disease are not known. It may be supposed that an action of external factor(s) on the immune system in the period preceding the appearance of clinical manifestations of the disease may be of decisive significance for the oligoclonal character of Ig in this disease.

Humans↗
PubMedDate not supplied

[Diagnostic value of quantitative and qualitative studies of cerebrospinal fluid immunoglobulins in multiple sclerosis].

The author reports the results of quantitative and qualitative investigations of immunoglobulins in the cerebrospinal fluid in multiple sclerosis and their evaluation in the aspect of their diagnostic usefulness. Determinations of the relative Ig level and the IgG index were of greater diagnostic usefulness than determinations of absolute Ig level. Already determination of the absolute level was valuable in cases with normal total protein level in the fluid. The results of quantitative determinations of Ig in the fluid were insufficient, however, for differential diagnosis against the group of diseases with local Ig production. Evaluation of the oligoclonal character of Ig in the fluid based on electrophoretic separation in agar and agarose was very useful in the diagnosis, but this phenomenon occurs also in a limited group of other central nervous system diseases. The abnormal ratio of kappa to lambda chains in the cerebrospinal fluid is of decisive importance for the diagnosis of multiple sclerosis. Complex quantitative and qualitative determinations of Ig in the cerebrospinal fluid are a significant advance in the diagnosis of multiple sclerosis making possible the correct diagnosis in cases with monosymptomatic or oligosymptomatic onset already in the first stage of the disease, and also in clinically silent periods e.g. before the first phase of the disease.

False Negative Reactions↗
PubMedDate not supplied

[Complement 3 level in the cerebrospinal fluid in multiple sclerosis].

Using the test of radial diffusion the absolute (mg%) and relative (% of albumin, % of total protein in cerebrospinal fluid) levels of the C3 component of the complement were determined in the cerebrospinal fluid and serum in a group of 61 cases of multiple sclerosis, and similar determinations were carried out in the control groups of patients with neurosis and organic diseases of the central nervous system. The absolute and relative levels of the C3 component in the cerebrospinal fluid in cases of multiple sclerosis were significantly lower (p < 0,001) and were independent of the levels of total protein and albumin in the cerebrospinal fluid. The low level of C3 in the cerebrospinal fluid was due to its low level in the serum in the same cases of multiple sclerosis, and the correlation coefficient of C3 levels in the cerebrospinal fluid and serum in this disease was r = 0.816. The C3 index studied in this work was statistically insignificantly lower in the group of multiple sclerosis with low C3 level in the cerebrospinal fluid as compared with the cases of this disease with normal C3 level in the cerebrospinal fluid. This shows that no data were obtained indicating a local consumption of complement components within the central nervous system in cases of multiple sclerosis. The possibility of a temporarily reduced complement consumption in the areas of demyelination cannot be excluded.

Albumins↗
PubMedDate not supplied

[Evaluation of treatment efficiency of acute hemispheric strokes using intravenous nimodipine infusions].

The authors present the results of treating acute hemispheric stroke with intravenous nimodipine. 17 patients were additionally treated with nimodipine given intravenously in 1 mg-2 mg dose, and the control group consisted of 71 patients treated in standard way with Dextran 40,000. The selection of patients for the study was random, and the treatment was conducted by blind trial method. All patients were admitted within 24 hours since acute stroke onset. The diagnosis was based on clinical examination and CT. The analysis of treatment results was made twice before and after the treatment according to criteria recommended by WHO Karnofsky scale. Statistical analysis showed that in the group treated additionally with nimodipine neurological and social consequences of stroke were significantly lower in comparison with standard therapy (p < 0.001).

Acute Disease↗
PubMedDate not supplied

[Diabetes and multiple sclerosis].

We report four patients who had multiple sclerosis associated with diabetes mellitus. Multiple sclerosis and diabetes mellitus share clinical, epidemiological and immunological features. The association between these two putative autoimmune diseases may suggest a similar pathogenic mechanism.

Adult↗