Search PubMed⌕ Search

Biomedical subjects

A Wahlin

Publications and source records attributed to A Wahlin.

103 records · Page 6Linked to original sources
PubMed1979

Identification of renal tubular epithelial cells in urine with immunofluorescence.

Rabbits were immunized with human kidney homogenate. The rabbit sera, after absorption with human liver homogenate, showed antibody activity against human kidney, renal pelvis and urinary bladder. The sera were then absorbed with human renal pelvis and urinary bladder mucosa and subsequently showed no antibody activity against urinary bladder or renal pelvis. Immunofluorescence examinations showed fluorescing cells in kidney tubules, but not elsewhere. The finally absorbed antihuman kidney sera were used for indirect immunofluorescence examination of urinary sediments from patients with renal disease. Phase contrast microscopy was used simultaneously. Fluorescence was found in cells which in phase contrast microscopy were judged to be renal tubular cells. Fluorescing cells were often found in casts, but free cells were also seen. Immunofluorescence may thus provide a means of identifying renal tubular cells in urine.

Animals↗
PubMed1978

Urine microscopy.

Explore the source record for details and available documents.

Hematuria↗
PubMed1978

Differential count and quantitative estimation of granulocytes, mononuclear leukocytes and renal epithelial cells in urine.

Voided urine samples from healthy persons and patients with glomerulonephritis, chronic pyelonephritis and bacterial urinary tract infection were examined. Urine from healthy persons contained 0-12 granulocytes/mm3, 0 mononuclear leukocytes/mm3 and -2 renal epithelial cells/mm3. Urine from patients contained a larger number of cells/mm3 than did urine from healthy persons. With differential counting of granulocytes, mononuclear leukocytes and renal epithelial cells patients with glomerulonephritis could be separated from patients with chronic pyelonephritis or bacterial urinary tract infection. The percentage values obtained at differential counting were not correlated to age, sex, total number of cells/mm3, proteinuria or serum creatinine level.

Adult↗
PubMed1977

The urinary sediment in hydronephrosis.

Phase contrast microscopy has been used for examination of urinary sediments from 19 patients with hydronephrosis. Casts were seldom seen. A raised number of erythrocytes was seen only in association with catheter, calculi or diabetes. A raised number of leukocytes was seen in patients with bacteriuria. A striking observation was the finding of a great proportion (64%) of histiocyte-like cells in six out of 12 cases in whom a differential count was performed. The proportion of histiocyte-like cells was small (14%) in cases with bacteriuria or history of urinary tract infection.

Adolescent↗
PubMed1975

Differential count of urinary leucocytes and renal epithelial cells by phase contrast microscopy.

A total of 291 urine sediments from 255 patients with various renal or urinary tract diseases have been studied by phase contrast microscopy. Based upon morphological criteria, leucocytes were distinguished from renal epithelial cells and the white blood cells were classified either as mononuclear or polynuclear in 179 patients. The percentage of the different cell types varied considerably between and within the different diseases. The median values for polynuclear granulocytes were higher than 90% in bacterial renal or urinary tract disease and in polycystic kidney disease. In interstitial nephritis, nephrosclerosis and in renal transplanted patients the percentage of polynuclear granulocytes was somewhat lower, 76-85%. In diabetes, amyloidosis, tubular nephrosis (necrosis) glomerulonephritis, lupus nephritis and endemic benign nephropathy there were 14-66% polynuclear granulocytes. 29-33% mononuclear leucocytes were found in lupus nephritis and endemic benign nephropathy. The greatest proportion of renal epithelial cells was found in endemic benign nephropathy, namely 49%. 36% renal epithelial cells were found in tubular nephrosis (necrosis) and in glomerulonephritis. The technique is rapid and inexpensive. It facilitates differential diagnostics of urinary tract disease with pyuria.

Amyloidosis↗
PubMedDate not supplied

Visuospatial functioning and spatial orientation in a community-based sample of healthy very old persons.

A population-based sample (n=219) of healthy older adults ranging from 75 to 96 years of age was examined in tests measuring visuospatial ability (modified Block Design Test) and spatial orientation (Clock Setting Test and Clock Reading Test). Results indicated an age-related deterioration in both visuospatial abilities and spatial orientation. Block Design performance was higher under self-paced than under paced conditions across the entire age range, although the beneficial effects from decreased pacing tended to increase with increasing age. Also, the clock test data suggest that the abilities underlying time recognition (clock reading) may deteriorate later in the normal aging process than those underlying time drawing (clock setting). Finally, regression analyses on the relationship between a variety of demographic, psychometric, and biological variables and visuospatial functioning showed that, in order of importance, years of age, Mini Mental State Examination (MMSE), and education, were significantly related to task performance.

Journal Article↗
PubMedDate not supplied

Trail Making Test performance in a community-based sample of healthy very old adults: effects of age on completion time, but not on accuracy.

A population-based sample of healthy old adults ranging from 76 to 93 years of age (n=94) was examined in the Trail Making Test (TMT), and in tests assessing motor functions of the hands (the dynamic and optic-spatial organization of the motor act). Results indicated no age-related differences in TMT accuracy, although the time required to complete the test increased with increasing age. Similar patterns of results were observed for TMT-A and TMT-B. There were no age-related differences in the tests of hand-motor functioning, and subjects were carefully screened on visual and auditory capacity, hence making it unlikely that motor and sensory factors contributed to the results obtained. A test of visuo-spatial skill (Block Design Test) was marginally related to performance on TMT-B, whereas sex, education, a marker of global cognitive status (the Mini-Mental State Exam), and tests of primary memory (digit dpan forward and digit span backward) made no contribution to TMT performance. Several biological variables (e.g. vitamin B12, albumin, blood pressure) were also unrelated to TMT performance, although a positive relationship between thyroid stimulating hormone and TMT-B performance was documented. It was suggested that the influence of age on TMT speed may reflect age-related deficits in a variety of task-relevant skills, including perceptual speed, attentional functions (e.g. vigilance, concentration, visual scanning), and visuo-spatial ability.

Journal Article↗
PubMedDate not supplied

Free recall and recognition of slowly and rapidly presented words in very old age: a community-based study.

This study addressed the effects of study time on episodic recall and recognition of words in a community-based sample of healthy older adults ranging from 75 to 96 years of age (N = 221). Results indicated a slight but reliable age-related deterioration of free-recall performance that was attributable to age deficits in secondary memory. The size of the age-related impairment in recognition was reduced relative to that in recall. As well, for all age groups, recall and recognition were higher when items were slowly as opposed to rapidly presented, indicating proficient utilization of study time in very old age. Finally, multiple regression analyses indicated that, although a variety of demographic (i.e., age and education), psychometric (i.e., Mini-Mental State Exam [MMSE] and Block Design scores), and biological (i.e., thyroid-stimulating hormone) variables were related to free-recall performance, only Block Design and MMSE scores made independent contributions to recognition performance.

Aged↗
PubMedDate not supplied

Visuospatial performance in very old demented persons: an individual difference analysis.

This study examines selected demographic, psychometric, and biological measures as predictors of visuospatial performance in a sample of 98 persons with mild to moderate dementia. Visuospatial performance was measured using standardized neuropsychology instruments, namely: Poppelreuter's figures, the clock test, and block design. Although multiple measures were initially correlated with performance on the selected visuospatial tests, the Mini-Mental State Examination was the exclusive predictor of Poppelreuter's figures and the clock test scores. For block design, years of education also contributed to the prediction model, but only among mildly demented persons. These results suggest that disease severity plays a dominant role in the prediction of visuospatial performance in dementia, particularly in more advanced stages of the disease. The differential role of education in predicting block design performance in mild vs. moderate dementia was also highlighted.

Aged↗