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Biomedical subjects

A W Shafer

Publications and source records attributed to A W Shafer.

23 records · Page 2Linked to original sources
PubMed1966

Etiology of leukemia. A review.

A variety of factors probably are etiologically involved in leukemia, not only in different cases but also within individual cases. Abnormalities of chromosomes have been found in various types of leukemia. Whether these chromosomal alterations are primary or secondary is undetermined, but it is likely that they are at least contributory in the development of leukemia. There is an increasing body of evidence incriminating viruses in leukemogenesis in man, and they may be a factor in all cases. Certain chemicals may be important etiologic factors in a few cases. Many different studies have established that ionizing radiation in large doses may be leukemogenic. Whether small doses of irradiation are dangerous has not been demonstrated.

Chromosome Aberrations↗
PubMedDate not supplied

Priapism during filtration leukapheresis.

Priapism has been observed during two out of 3,680 filtration leukapheresis procedures in male donors and has been reported during hemodialysis. Both procedures are associated with enhanced granulocyte adhesion and aggregation presumably due to C5a. During both procedures, heparin is administered and this drug has been shown to cause heparin-dependent anti-platelet antibodies. It is suggested that complement mediated venous leukostasis or immune-induced platelet aggregates might impair the normal blood flow from the penis and result in a state of priapism.

Adult↗
PubMedDate not supplied

Broadening the base of a rare donor program by targeting minority populations.

Some red cell phenotypes are found exclusively in one race and may be of low frequency. Finding compatible blood for patients needing one of these rare types has been extremely difficult. A program was implemented to screen large numbers of donors for blood types found solely in their racial group. Implementation steps included obtaining broad community endorsement of the concept, educating blood service personnel, developing educational materials, enlisting the support of a knowledgeable physician from a minority group, developing a computer program to facilitate selection of donors to be tested, beginning the program and making the necessary adjustments, doing the laboratory testing to identify rare bloods, notifying the rare donors, and maintaining the enthusiasm of the entire blood service for the rare donor screening program. After 7706 black donors were typed, 1 Cr-, 5 Hy-, 24 U-, and 20 Js(b-) persons were found; one U- donor was also Js(b-).

Black People↗