Fatal multisystemic toxicity associated with prophylaxis with pyrimethamine and sulfadoxine.
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Adult↗
Biomedical subjects
A W Macfarlane
Publications and source records attributed to A W Macfarlane.
Necrobiotic xanthogranuloma with paraproteinaemia.
A 66-year-old man with necrobiotic xanthogranuloma associated with paraproteinaemia is described. He also had long-standing normolipaemic plane xanthomata. Treatment was with melphalan 0.15 mg/kg body weight/day. Initially, three 5-day courses were given at 4-weekly intervals but a fourth course was necessary after a further 4 months because of a deterioration in both his skin and associated systemic symptoms.
Aged↗
Pyoderma gangrenosum treated with cyclosporin A.
A 49-year-old woman with a 14-year history of pyoderma gangrenosum unresponsive to a variety of systemic and topical treatments was given oral cyclosporin A (CyA), a potent immunosuppressive agent widely used in organ transplantation for the prophylaxis of acute graft-versus-host disease. Improvement and subsequent healing of the lesions was evident within 3 weeks of starting treatment and has continued for the duration of treatment (12 months).
Adult↗