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Biomedical subjects

A W Fisher

Publications and source records attributed to A W Fisher.

At least 19 recordsLinked to original sources

Fine vascular anatomy of adult rabbit knee ligaments.

The microvascular anatomy of discrete knee ligaments in adult rabbits is described. Epiligamentous plexuses give rise to a limited number of vessels which penetrate deeply into ligament substance. Intraligamentous vessels are usually longitudinally orientated, widely separated linear anastomoses but occasionally complex glomus-like configurations are present. The significance of these findings is discussed in relation to other articular connective tissues and to the possible roles of the intraligamentous microvasculature.

Animals↗

Immunocytochemical localization of urotensin I neurons in the caudal neurosecretory system of the white sucker (Catostomus commersoni).

The localization of urotensin I has been investigated in the caudal neurosecretory system of the white sucker (Catostomus commersoni). The peptide is present in all the cells of the system both large and small, in the large axons passing to the urophysis, and in fine beaded fibres not only within the urophysis but also in a fine plexus lateral to the large cells in the spinal cord proper. The possibility that the caudal neurosecretory system is not a functionally uniform system but rather a collection of dissimilar cells of different synaptic inputs with a common entity, urotensin I, is discussed. Moreover, the feasibility of a urotensin-I feedback loop is described.

Animals↗

The muscle layer of the canine gallbladder and cystic duct.

The muscle layer of the canine gallbladder wall and cystic duct was found to be a three-dimensional meshwork of smooth muscle bundles which appear loosely and irregularly arranged on the mucosal aspect and consolidate to form a homogeneous plate-like layer on the serosal aspect. The muscle bundles are tightly woven around interspersed pockets of loose connective tissue in the gallbladder wall and gradually become loosely arranged with more prominent amounts of intervening connective tissue in the cystic duct. The muscle layer is thickest in the gallbladder wall and becomes progressively thinner out into the cystic duct. No anatomic sphincter was observed. Ultrastructural organization revealed individual muscle fibers to be of irregular profile, often branching, widely spaced with intervening collagen fibers, and having few cell-to-cell contacts.

Animals↗

Salivary gland heterotopia: a unique cerebellopontine angle tumor.

An unusual maldevelopmental lesion, a salivary gland heterotopia of the right cerebellopontine angle, was studied. There was an associated primary adenoid cystic carcinoma. Possible modes of development and the relationship to salivary heterotopia of the middle ear are discussed.

Adult↗

A 3-dimensional reconstruction of the hypothalamo-neurohypophysial system of the rat. The neurons projecting to the neuro/intermediate lobe and those containing vasopressin and somatostatin.

A three-dimensional reconstruction of the rat's hypothalamo-neurohypophysial system, depicting the neurons that project to the neuro-intermediate lobe of the pituitary, has been made by using retrograde transport of horseradish peroxidase injected into the neuro-intermediate lobe and by using immunocytochemistry with antisera to vasopressin and somatostatin. The overall picture illustrates the neurons situated in the walls of a pair of ill-defined cone-shaped tunnels, the apices pointing anteriorly. Among the neuronal aggregates in the tunnel wall two, the paraventricular and forniceal nuclei, appear similar in shape but clearly separated by a gap of at least 150 micrometers. Many of the vasopressin-positive neurons lie in the same nuclear aggregates with two notable exceptions: the suprachiasmatic nucleus contains many vasopressin-positive cells but does not project to the pituitary, and the forniceal aggregate, which does project to the pituitary, contains no vasopressin-positive cells. Somatostatin-positive cells are situated close to the third ventricle and their size is intermediate between parvocellular and magnocellular. Cell counts show only half the cells in the system lying in the supraoptic and paraventricular nuclei, the rest being in "accessory nuclei".

Afferent Pathways↗

Solitary liver nodules.

There has been confusion in the literature over the nomenclature of solitary liver nodules. Several such lesions have recently been reported in patients taking oral contraceptives. Similarities exist between these cases that suggest they may be examples of focal nodular hyperplasia. Here three further cases are presented. The criteria for making the diagnosis and its importance are discussed.

Adult↗