Biomedical subjects

A W Crossley

Publications and source records attributed to A W Crossley.

22 records · Page 2Linked to original sources

PubMed1987

Radiographic study of intercostal nerve blockade in healthy volunteers.

The spread of solutions injected to the intercostal space was studied in 10 healthy volunteers. Up to 20 ml of a 50:50 mixture of local anaesthetic solution and a radiopaque dye was injected through a modified extradural catheter placed in an intercostal space at the posterior angle of the rib. Radiographic films demonstrated spread by an extrapleural route into adjacent intercostal spaces and this was confirmed by the occurrence of analgesia in the corresponding dermatomes. The relevance of these results to clinical practice is discussed.

Adult↗

PubMed1983

The effect of an inhibitory factor from the bovine retractor penis on the gastro-intestinal tract and gall bladder of the guinea-pig.

1 The effect of a smooth muscle inhibitory factor extracted from the bovine retractor penis has been examined on a variety of in vitro smooth muscle preparations from the guinea-pig alimentary canal and on the guinea-pig gall bladder. 2 The inhibitory factor caused relaxation of spontaneous and carbachol-induced tone in the taenia coli, the stomach fundal strip and the duodenum and colon. There was little effect on the ileum. Sensitivity was highest in the taenia coli where the response to the inhibitory factor mimicked the response to stimulation of the non-adrenergic, non-cholinergic (NANC) inhibitory nerves. 3 In the taenia coli the inhibitory response to stimulation of the NANC nerves and to ATP was abolished by apamin 5 x 10(-8) M, whereas this or higher concentrations had no effect on the response to the inhibitory factor. This makes it unlikely that the latter is the neurotransmitter in these NANC nerves. 4 The inhibitory factor had no effect on the gall bladder. Inhibitory responses to field stimulation were obtained in this tissue but these were insensitive to tetrodotoxin in concentrations greater than those needed to block the motor cholinergic nerves.

Adenosine Triphosphate↗

PubMed1979

The effect of morphine and some other narcotic analgesics on brain tryptophan concentrations.

An acute dose of morphine increased brain tryptophan in mice. This effect was not prevented by naloxone nor was it produced by other narcotic analgesics. Dextrorphan, but not levorphanol, had a similar effect to morphine. A large dose of tryptophan had no effect on the antinociceptive action of morphine in mice. Morphine increased brain tryptophan in rats. This effect was prevented by naloxone. A large dose of tryptophan antagonised the antinociceptive action of morphine in the rat.

Analgesics, Opioid↗

PubMedDate not supplied

Postoperative shivering.

Shivering is common during recovery from anaesthesia. Factors in the aetiology include the use of volatile anaesthetic agents, prolonged anaesthesia, gender and age. The relationship between postoperative shivering and thermoregulation is not clear. Management should include measurement of the patient's temperature.

Anesthesia, General↗