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Biomedical subjects

A Volpe

Publications and source records attributed to A Volpe.

At least 253 records · Page 14Linked to original sources
PubMed1982

Endocrinological features and endometrial morphology in climacteric women receiving hormone replacement therapy.

Prolactin (PRL), follicle stimulating hormone (FSH), luteinizing hormone (LH), oestrone (E1), and oestradiol (E2) levels were determined in 204 women who were receiving hormone replacement therapy for their climacteric symptoms. The changes in these hormone levels and the endometrial morphology were studied in order to determine the effects of the replacement therapy. The women were divided into two groups: the first group of 120 women was treated with conjugated oestrogens administered cyclically, plus norethisterone acetate. The second group of 84 women received oral oestriol succinate, also administered cyclically but without additional progestogens. The oestrogen-progestogen therapy resulted in a disappearance of the climacteric symptoms and a significant decrease of FSH and LH levels. Oestriol therapy was less effective than the conjugated oestrogens as a replacement therapy. Oestriol therapy also resulted in a less remarkable decrease of gonadotrophin levels. There were no significant changes in prolactin levels in either group of women. The endometrial histology did not change significantly after either of the two hormone replacement therapies.

Climacteric↗
PubMed1982

An intrauterine progesterone contraceptive system (52 mg) used in pre- and peri-menopausal patients with endometrial hyperplasia.

An intrauterine progesterone contraceptive system (IPCS) (52 mg) was inserted in 25 women with cystic endometrial hyperplasia. Among these women, 11 complained of heavy climacteric symptoms and also received an oestrogen replacement therapy consisting of conjugated oestrogens (0.625 mg/day) administered cyclically for 3 out of 4 wk. Prior to the therapy and after 6 mth of treatment, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), oestrone (E1) and oestradiol (E2) plasma levels were measured and endometrial histology was evaluated. In the women receiving IPCS treatment alone, there were no significant changes in FSH, LH, PRL, E1 and E2 plasma levels. However, there were remarkable changes found in their endometrial histology. In the remaining women receiving both treatments there was a sharp decrease in FSH and LH plasma levels and an increase in E1 and E2 plasma levels, while the prolactin levels remained unchanged. With the exception of two of these women, the endometrial histology changed remarkably. The endometrial morphology of the two exceptions remained unchanged. All climacteric symptoms disappeared after the administration of both IPCS and the oestrogen replacement therapy. The remarkable changes which did occur in the endometrial histology resulted in a less active glandular epithelium and stromal decidual formation, thus proving a useful effect of treatment.

Adult↗
PubMed1982

Circadian rhythm of testosterone and prolactin in the ageing.

The role which testicular hormones have on the decrease of sexual function in ageing men is still uncertain, but of primary interest. Previously, it has been known that the impairment of Leydig cell activity is a causal factor in the decreasing sexual function in ageing men. The present study is an evaluation of some chronobiological aspects, which directly or indirectly concern the 'Gonadostat' in ageing men, in order to determine of any change of the hypothalamic-pituitary axis occurs during the ageing process. The results from a group of 18 young men aged between 21 and 37 were compared with the results from a group of 28 older men between the ages of 67 and 98. The daily variations of testosterone (T) levels were determined in both groups of men as its circadian rhythm is well known in adult men. Moreover, the nocturnal secretory pattern of prolactin (PRL) was studied in 6 of the 28 elderly men. When comparing the usual increase of T levels in adult men, which occurs in the morning, there were no significant differences found in the older group of men between early morning and evening. The PRL levels showed no nocturnal increase in 4 of the 6 men. A hormonal impairment in the central nervous system may, in fact, be associated with the testicular deficiency leading to the decrease in sexual function of ageing men.

Adult↗
PubMed1982

Prolactin and certain obstetric stress conditions.

Prolactin levels were evaluated during certain stress conditions, obstetric or gynecologic surgical interventions, labor, and birth. In 68 patients undergoing voluntary abortion, prolactin levels were measured to study the effect of anesthetics and of dilatation and curettage on hormonal secretion. Prolactin levels were evaluated in five patients undergoing elective cesarean section and in five post-menopausal patients undergoing total abdominal hysterectomy with bilateral oophorectomy. Moreover, prolactin concentration in serial samples of blood was estimated in 32 normal patients with spontaneous vaginal delivery at term and in 16 newborns at term after 30-60 and 120 min following birth. Prolactin responsiveness to TRH was evaluated in 12 newborns at the 4th day of life. Plasma prolactin levels rose in all the stress conditions investigated except in labor, during which hormone levels showed a decrease starting 2 h before delivery and reaching the lowest value 1 h prior. From this moment on there was a remarkable rise in prolactin concentration, with a peak 1 h after delivery. The decrease in prolactin levels during labor could possibly be due to an increase in dopaminergic activity. Moreover, the finding of no variation of prolactin levels during induced abortion in a group of patients pretreated with methysergide supports the view that the serotoninergic system also affects prolactin release.

Abortion, Induced↗
PubMed1980

Behaviour of HPL and GH plasmatic rate in pregnant women at different times of their pregnancy during dynamic tests.

The authors have studied the effects of an oral or intravenous glucose load, of insulinic hypoglycemia, of arginine and the effects of the 2-deoxi-glucose on the plasmatic concentration of HPL and GH on pregnant women at different times during their pregnancy. None of the used tests seemed able to modify in any way the plasmatic concentration of the placental lactogen hormone; the somatotropinic response to the different stimuli happens to be lower than that found in non pregnant women of the same age. We and by asserting that unlike what happens with the GH, there does not exist a direct "feedback" between the modifications of plasmatic concentration of the main underlayers and HPL.

Arginine↗
PubMed1978

Surgical treatment of congenital club foot. (Comparison of the results of Codivilla's operation with those of Turco's modification).

The purpose of this paper is to compare the results of the classical Codivilla operation with those obtained from the same operation as modified by Turco. The authors have assessed ninety one feet in sixty eight patients treated between 1968 and 1975. The severity of each foot was assessed before and after corrective treatment according to the classification of Manes et al., 1975. The results were determined according to the classification of Mastragostino et al., 1976, based on the clinical, radiographic and functional findings. In this connection, the authors attached particular importance to the dorsiflexion test. Based on their findings in this survey, the authors assert that Turco's modification of the classical Codivilla operation enhances the results.

Age Factors↗