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Biomedical subjects

A Voller

Publications and source records attributed to A Voller.

At least 145 records · Page 8Linked to original sources
PubMed1968

Serological malaria surveys in Nigeria.

A parasitological and serological malaria survey of 2 large and 2 small areas of Nigeria was carried out in connexion with the activities of the WHO Treponematoses Epidemiological Team.The results, based on data obtained from 1082 subjects, showed that all the areas were holoendemic with the usual pattern of malariometric indices, and that the differences between the parasite rates of the two large areas were due to the different timing of the survey in relation to the seasonal wave of transmission.The fluorescent antibody test was positive (>/=1:20) in 92% of the 914 sera collected from these 2 areas.The serological profile of the population in the 2 areas was similar, but the immunofluorescence titres were higher in all age-groups in the area south of the Benue river, indicating the antibody response to the previous endemic wave rather than the actual amount of transmission taking place at the time of the survey.This study confirms the value of the immunofluorescent technique for large-scale malaria surveys, but indicates the need for caution in interpreting the results and stresses the importance of good knowledge of the local epidemiology of malaria before embarking on application of serological methods.

Fluorescent Antibody Technique↗
PubMed1967

Splenomegaly in New Guinea.

Seeking to determine whether there is a relationship in New Guineans between hepatic sinusoidal infiltration and splenomegaly on the one hand and malaria on the other, the authors studied 24 adults from a village protected from malaria for 5 years by 6-monthly DDT spraying and 34 adults from an unprotected village with hyperendemic malaria.It was found that clinical splenomegaly tended to be associated with greater hepatic sinusoidal infiltration among persons from the malarious village and that higher malaria antibody titres were more common in patients with splenomegaly in this village. In adults in the protected village the prevalence of malaria parasitaemia was much lower than in the malarious village and the sinusoidal infiltrates were also diminished.No associations between parasitaemia, malaria antibody titre, and hepatic sinusoidal infiltration could be demonstrated in the malarious village. The implications of these findings are discussed and the question of malaria being responsible for the marked splenomegaly encountered in tropical practice is discussed.

Adult↗