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Biomedical subjects

A Vogt

Publications and source records attributed to A Vogt.

222 records · Page 13Linked to original sources
PubMedDate not supplied

High-dose intravenous penicillin G does not prevent further progression in early neurological manifestation of Lyme borreliosis.

We report two cases of Lyme borreliosis (LB) with erythema migrans (EM) and simultaneous meningopolyneuritis with radicular pain and lymphocytic pleocytosis in the cerebrospinal fluid (CSF). EM and pain disappeared completely under high-dose penicillin G therapy within few a days. Pathological findings in CSF improved. Nevertheless, during and after therapy, neurological signs of LB developed: cranial nerve palsies as well as paresis of extremity muscles with radicular distribution.

Abducens Nerve↗
PubMedDate not supplied

Vagal and sympathetic reflexes of left ventricular origin on the efferent activity of cardiac and renal nerves on anaesthetized cats.

The influence of reflexes of left ventricular origin on the postganglionic sympathetic activity and heart rate was investigated in anaesthetized cats. The experiments were to clarify 1. whether there are regionally different reflex adjustments due to an activation of ventricular receptors, 2. whether an increase of left ventricular diastolic pressure, which is known to activate afferent vagal fibres, causes an inhibition of sympathetic activity, 3. whether a coronary artery occlusion can activate a pressor reflex and a depressor reflex. Left ventricular receptors were stimulated by obstruction of the aortic root, coronary artery occlusion and mechanical stretch of the ventricular wall. In animals with intact CNS, all stimuli led to an inhibition of the activity of the inferior cardiac and renal sympathetic nerves and bradycardia. These reflex effects are initiated by mechanoreceptors and abolished by vagotomy. The inhibition of sympathetic activity was equally pronounced in the cardiac and renal nerves. After coronary artery occlusion and aortic obstruction, inhibition occurred as soon as the ventricular diastolic pressure had risen about 2 mmHg. In spinal animals both stimuli caused a sympathetic activation which was mainly restricted to the cardiac nerve. This activation is not due to mechanical changes, but rather a direct result of myocardial ischaemia. Coronary artery occlusion is able to produce both inhibition and activation of sympathetic fibres, but the activation is normally suppressed and thus seems not to be particularly important for circulatory control.

Animals↗
PubMedDate not supplied

Does digoxin sensitize left ventricular mechanoreceptors?

Afferent nerve fibre activity from left ventricular mechanoreceptors was recorded in 10 anaesthetized cats before and after two intravenous injections of 15 micrograms/kg digoxin at 1 hour interval. These receptors are activated by coronary artery occlusion and induce a depressor cardiovascular reflex resulting in bradycardia and hypotension. Neither the spontaneous activity of the receptor's afferent nerve fibres nor their maximum activity during temporary coronary artery occlusion was affected by digoxin. The results show that digoxin in therapeutic doses has no sensitizing effect on left ventricular mechanoreceptors with vagal afferent fibres. The sensitization of cardiopulmonary baroreflexes by digitalis glycosides shown in previous investigations is thus more likely to be mediated by a central nervous effect of the drug.

Animals↗
PubMedDate not supplied

Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch.

While vascular endothelial cells are repeatedly stretched by the pulsatile nature of cardiac output, in vitro models traditionally used to study vascular biology involve static culture techniques. We have recently shown that pulsatile stretching of endothelial cells in culture will increase their rates of proliferation and regulate their secretion of macromolecules. The aim of this study was to determine whether membrane adenylate cyclase is involved in intracellular signalling during pulsatile stress. Bovine aortic endothelial cells were seeded on flexible-bottomed culture wells (3 x 10(5) cells/25 mm well) and allowed to attach for 48 hours. The culture wells were placed in a vacuum-operated stress providing instrument and subjected to 0.5 s of 24% strain, 0.5 s relaxation (60 cycles/min) for 0, 1, 3, 5, 7, 10 and 15 minutes (N = 24 wells/time point). Cells were homogenized and a crude membrane preparation (27,000 x g) was assayed for adenylate cyclase under basal and forskolin (100 microM) stimulated conditions. The results indicate that there is a time-dependent increase in both basal and stimulated adenylate cyclase with cyclic deformation and suggest that there may be a "stretch receptor" coupled to adenylate cyclase which can modulate endothelial cell function with hemodynamic changes.

Adenylyl Cyclases↗
PubMedDate not supplied

[Critical life change events and adjustment in a group of elderly single women].

Women that were children or adolescents during World War II have rarely been studied in psychological and sociological research. Because of the death of over 3.5 million German men in that war, there remained many single (especially, never-married) women of corresponding age. In a research project at the University of Münster some psychological and social aspects of the life situation of never-married, employed women born between 1919 and 1933 in comparison to married women of the same age that had never been employed were studied by means of detailed interviews. Parts of the results concerning the retrospective experience of critical life events and coping strategies are described. The results indicate that the interviewees were confronted with difficult life events, but that they coped with them in a very active way. Differences between women of different martial statuses (e.g., for the never-married women a more frequent mentioning of events concerning the war, a higher involvement in personal health problems, a lower importance of their occupation than expected by the authors, and, for example, for the married women a higher family-centeredness) are discussed.

Adaptation, Psychological↗