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Biomedical subjects

A Vissink

Publications and source records attributed to A Vissink.

At least 109 records · Page 6Linked to original sources

[Dental implants: a better anchor for dentures].

Loss of teeth results in resorption of the jaws. As a consequence the denture bearing area progressively reduces, eventually causing loss of retention and stability of the conventional denture. In three patients, two women aged 36 and 37 and a man aged 46, suffering from severe problems with their conventional dentures endosteal implants were inserted in the jawbone. After the healing period the dentist fabricated an implant-retained overdenture. The patients were very satisfied with the final result. Endosteal implants are, especially in the mandible, a reliable treatment modality for a stable implant-retained denture in case of patients suffering from retention problems with their conventional dentures.

Adult↗

On the chemical characterization of colloid cyst contents.

Colloid cysts of the third ventricle have been investigated by chemical characterization of the cyst contents using ELISA with monoclonal antibodies for certain carbohydrate epitopes as well as a polyclonal antiserum against peptide domains, and immunohistochemistry on the cyst wall using the same antibodies. Furthermore, the carbohydrate composition of one sample has been determined after gel filtration. The cyst contents reacted strongly with the monoclonal antibody for the sulfo-Lewis epitope, and with the antimucin polyclonal antiserum. In one case the cyst fluid exhibited a blood group A antigen. A sample of cyst wall obtained by biopsy showed strong immunoreactivity against sulfo-Lewis antigen, and the sialo-Lewis antigen. The presence of the S atom with its high atomic number relative to that of C, H, and O atoms, may contribute to the high density appearance of colloid cysts on CT-scans. The sulfo-Lewis and sialo-Lewis carbohydrate epitopes are known as ligands for selectins, involved in inflammatory processes, and may well account for the aseptic meningeal reaction that may follow spilling of cyst contents during operative evacuation. The carbohydrate epitopes exhibited by colloid cysts and their contents, have also been reported for the mucins of salivary glands, uterine cervix, gall bladder and colon, and therefore, are not inconsistent with the assumption of an endodermal origin of colloid cysts.

Biopsy↗

Risks for oral health with the use of antidepressants.

In this article, attention is focused on oral pathology, particularly dental caries, caused by hyposalivation as a consequence of (long-term) use of antidepressants. Changes in clinical psychiatric practice and increasing numbers of prescriptions of antidepressants in primary care and specialty care settings have made awareness of this risk even more relevant than in the past. Normal physiology of salivary glands and changes in the secretion of saliva during use of antidepressants are described. Monitoring, prevention, and treatment of hyposalivation induced by antidepressants are encouraged as an adjunct in the clinical management of depression.

Antidepressive Agents↗

Dentin dysplasia type I: five cases within one family.

Five cases of dentin dysplasia type I within one family are described. Clinically and radiologically, such patients are characterized by a delayed eruption pattern, opacity of the incisional margins, hypermobility of the teeth, short and defective roots, and obliterated pulp chambers. A conservative attitude toward the treatment of common conditions in dentin dysplasia type I favors the preservation of a vulnerable dentition.

Child↗

[Dental foci. Role, treatment and prophylaxis in patients at risk].

A dental focus usually is a localized chronic infection that under certain circumstances may result in severe local or systemic disease. The most important dental foci are periodontitis, periapical lesions, advanced carious lesions, nonvital pulp, partially impacted teeth and root tips. Local effects of dental foci particularly are processes that may come to expression because of a compromised immunological defence, such as osteoradionecrosis. Systemic effects are mainly caused by transient bacteraemia which can occur spontaneously out of dental foci or after manipulations such as brushing, flossing and dental treatment. Well known examples are infectious endocarditis, fever during chemotherapy and hematogenous infections of total joint prostheses. For all patients at risk (a.o. endocarditis, endoprosthesis, chemotherapy, radiotherapy) it is important that dental foci are treated. Because in most patients the risk factors are present lifelong, a healthy dentition and a healthy periodontium are the best way of prevention.

Antibiotic Prophylaxis↗

[Relapse after endodontic treatment: endodontic retreatment or apex resection?].

In many cases, unsuccessful endodontic treatment is followed by apicoectomy. Endodontic retreatment, however, could be an appropriate alternative for apicoectomy more frequently. In this paper indications, specific problems and treatment methods are presented for endodontic retreatment, apicoectomy and intentional replantation.

Apicoectomy↗

[Syndromes 4. Sanfilippo syndrome].

The Sanfilippo syndrome belongs to the mucopolysaccharidoses. In this syndrome heparansulfate accumulates in the lysosomes because of an enzymatic disorder in the degradation of mucopolysaccharides. The result is a function disorder of the involved tissues. The Sanfilippo syndrome is characterized by a combination of mental deterioration from the third year of life, hepatosplenomegaly and a typical facial appearance. These characteristics and the implications for dental treatment are discussed.

Craniofacial Abnormalities↗

[Syndromes 5. Williams-Beuren Syndrome].

A characteristic facial appearance, mental retardation, growth deficiency, cardiovascular anomalies, and infantile hypercalcemia are major features of the Williams-Beuren syndrome. The dentist can contribute to the (early) diagnosis of this disorder.

Chromosomes, Human, Pair 7↗

Efficacy of a synthetic polymer saliva substitute in reducing oral complaints of patients suffering from irradiation-induced xerostomia.

OBJECTIVE: A saliva substitute based on polyglycerylmethacrylate, lactoperoxidase, and glucose oxidase (Oral Balance) has been developed. The aim of this study was to evaluate the effect of Oral Balance on the dryness-related oral complaints in patients suffering from irradiation-induced xerostomia. METHOD AND MATERIALS: The efficacy of Oral Balance on the dryness-related complaints of 28 patients was assessed by means of self-administered questionnaires. Each patient completed an initial questionnaire about dryness-related symptoms and then was given the moistening gel. The patients were instructed to apply the gel as often as desired. After 2 weeks and 3 months, the patients were asked to complete a progress questionnaire. The severity of xerostomia was measured with a saliva absorption method. RESULTS: All patients suffered from moderate-to-severe xerostomia, the severity of which did not change during the experimental period. Three patients did not complete the study. In the other 25 patients, the application of Oral Balance tend to diminish the sensation of oral dryness and improve oral functioning. Statistically significant reduction of the dryness-related complaints was observed only in the patients suffering from severe xerostomia. CONCLUSION: Use of Oral Balance is of potential benefit in patients suffering from severe xerostomia.

Aged↗

Bone grafting of the floor of the maxillary sinus for the placement of endosseous implants.

This study describes and evaluates a technique to augment the floor of the maxillary sinus and to widen the alveolar crest of the atrophic posterior maxilla with autogenous bone. The subjects were 43 patients whose maxillary alveolar crest was not high enough to permit reliable placement of endosseous implants in the posterior maxilla. Large autogenous cancellous bone grafts (n = 37) or smaller grafts from the mandibular symphyseal area (n = 5) or the maxillary tuberosity (n = 1) were harvested. The operations were done in either one stage (n = 20 patients, 36 sinuses) or two (bone grafting followed by placement of implants, n = 23, 45 sinuses). In 28 cases the sinus membrane was perforated with no subsequent problems. Nine of the 171 Brånemark implants that were inserted were lost during follow-up (mean 26 months, range 8-62 months). Augmentation of the maxillary sinus with autogenous bone is a reliable way of achieving placement of an implant.

Adolescent↗

Bone height measurements on panoramic radiographs: the effect of shape and position of edentulous mandibles.

OBJECTIVE: The aim of this study was to quantify the effect of mandibular angulation, position, and shape of an edentulous mandible on the distortion of its image in panoramic radiographs. STUDY DESIGN: Five edentulous dry mandibles varying in size from small to wide and equipped with metal bars in and on top of the mandible were used. The mandibles were radiographed at nine different positions by tilting the mandible posteriorly around a transversal axis, using an orthopantomograph. RESULTS: The length of the images of the bars on top of the mandible increased significantly by tilting the mandibles from +20 degrees to -20 degrees. The magnification factor of the images of the intrabony bars in the mandible was the largest at 0 degrees and decreased significantly by both decreasing or increasing the inclination. The size of the mandible was not related to the magnification factor. CONCLUSION: For both diagnostic and evaluation purposes of the edentulous mandible, the panoramic radiograph is not a reliable radiographic technique unless meticulous precautions are taken for reproducible positioning of the patient in the apparatus.

Acrylic Resins↗

Muscarinic receptor stimulation increases tolerance of rat salivary gland function to radiation damage.

PURPOSE: To investigate if muscarinic receptor-stimulated activation of the PLC/PIP2 second messenger pathway prior to irradiation increases the radiotolerance of rat salivary gland. MATERIALS AND METHODS: Rats were treated with pilocarpine, methacholine, reserpine, methacholine plus reserpine, or atropine prior to irradiation with a single dose of 15 Gy X-rays. Parotid and submandibular/sublingual saliva was collected 4 days before and 1-30 days after irradiation. Lag phase, flow rate, amylase secretion, and salivary sodium and potassium concentration were measured. RESULTS: Pretreatment with pilocarpine or methacholine resulted in an improvement of all measured functions of both glands. Pretreatment with reserpine had no effect on parotid gland function. Reserpine plus methacholine did not increase parotid gland function when compared with methacholine alone, indicating a purely muscarinic receptor stimulation as the initiator for the induced radioprotection. Pretreatment protective effects on submandibular gland function of reserpine plus methacholine were additive, indicating cooperation of muscarinic and alpha-adrenergic receptors. Atropine pretreatment slightly increased the radiation induced loss of salivary gland function. CONCLUSIONS: Preirradiation activation of PLC/PIP2 second messenger pathway through stimulation of muscarinic receptors reduces the salivary gland radiosensitivity. The observed protection of salivary gland function may be of a secondary nature, implicating a cell conditioning after receptor stimulation of the PLC/PIP2 pathway.

Animals↗