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Biomedical subjects

A Virgili

Publications and source records attributed to A Virgili.

At least 19 recordsLinked to original sources
PubMed2004

Oral isotretinoin and haemophilia A.

The effects of oral isotretinoin on the coagulation system are still not well known: some case reports describe thrombocytopenia or thrombocytosis, others present different effects on fibrinolysis. We report a case of severe acne treated with oral isotretinoin in a patient affected with haemophilia A. In this case, which differs from the only other case reported in the literature, oral isotretinoin did not appear to influence the haemophilic patient's need of factor VIII.

Acne Vulgaris↗
PubMed2003

Primary cutaneous CD30+ large T-cell lymphoma in a patient with psoriasis treated with cyclosporine.

We report the case of a 61-year-old woman who developed an anaplastic CD30+ cutaneous T-cell lymphoma during oral cyclosporine (CsA) therapy for recalcitrant psoriasis. Two months after CsA discontinuation, clinical and histological resolution of the lymphoma was observed. However, 3 years later extracutaneous involvement of the lymphoma could be detected. The association between CsA administration and the occurrence of the lymphoma may be casual, but a relationship with immunosuppression may also be hypothesized. We have reviewed all relevant data in the literature. To our knowledge, this is the first case of primary cutaneous CD30+ anaplastic large T-cell lymphoma in a patient treated with CsA for psoriasis.

Biomarkers, Tumor↗
PubMed2002

Preparation and structural study of the enantiomers of alpha,alpha'-bis(trifluoromethyl)-9,10-anthracenedimethanol and its perdeuterated isotopomer, highly effective chiral solvating agents.

Enantiopure forms of alpha,alpha'-bis(trifluoromethyl)-9,10-anthracenedimethanol and the corresponding perdeuterated isotopomers were prepared. The conformational study was carried out by (1)H NMR, and the absolute configuration was determined by the X-ray study of the crystallized diastereoisomeric carbamate derivative. This compound was tested as a chiral solvating agent (CSA). The results showed very good discrimination for several racemic mixtures that improved other classical methods. The study of diastereomeric complexes was carried out by determination of the stoichiometry of the complex and the binding constant of the equilibrium.

Journal Article↗
PubMed2002

Granulomatous lesions of the homolateral limb after previous mastectomy.

BACKGROUND: Granulomas may be classified as palisaded, sarcoidal, tuberculoid, suppurative and foreign body. In cancer patients they are defined as tumour-related sarcoid granulomas. Otherwise they are classified as granulomatous lesions of unknown significance. It is still unknown why neoplastic diseases are sometimes associated with granulomas. OBJECTIVES: To investigate granulomas found on the same side as a previous mastectomy. METHODS: We studied four women who had previously undergone mastectomy and presented with epithelioid cell granulomas of the same side as the previous mastectomy. CONCLUSIONS: The association between breast cancer and host granulomatous reaction is uncommon. The cases discussed may correspond to cutaneous tumour-related sarcoid granuloma reactions.

Aged↗
PubMed2001

Managing vulvar lichen simplex chronicus.

OBJECTIVE: To develop a flow chart indicting which tests to perform with the aim of helping physicians with the diagnosis, management and treatment of lichen simplex chronicus. STUDY DESIGN: We reviewed the data on vulvar lichen simplex chronicus patients to delineate proper management. RESULTS: Patch test should be added to the series of tests performed to ascertain the causes of vulvar lichen simplex chronicus. CONCLUSION: Among the stimuli that may trigger vulvar lichen simplex chronicus, not only infections and irritating factors but also sensitization must be kept in mind, especially in long-lasting disease.

Decision Trees↗
PubMed2000

p53, cyclin-D1, PCNA, AgNOR expression in squamous cell cancer of the lip: a multicenter study.

BACKGROUND: The development of squamous cell carcinoma of the lower lip is an interesting model of photocarcinogenesis because of the structural and topographic characteristics of the lips. The purpose of this study was to evaluate the expression of immunohistochemical markers on the lips of patients with lower lip squamous cell carcinoma (LLSCC), compared with a control population. METHODS: Of the 98 subjects involved in the study, 58 were suffering from squamous cell carcinoma of the lower lip. The remaining 40 acted as a control. The case studies were taken from six university and hospital dermatology and plastic surgery departments. Questionnaires were administered to assess the risk factors for LLSCC. The cases involving squamous cell carcinoma underwent surgical excision and punch biopsy specimens were obtained from 20 control patients. Tissues were prepared in 5-microm-thick sections to carry out the following immunohistochemical study: PCNA, p53, AgNOR, cyclin-D1, bcl-2. RESULTS: The lower lip was the predominant location of squamous cell carcinoma, with the following factors playing important roles: chronic sun exposure, history of smoking, alcohol use and familial risk of cutaneous tumors. The male/female ratio in our survey was 5:1. The p53 protein was positive in approximately 50% of SCC cases and in 20% of controls. This protein is mostly associated with chronically photoexposed skin areas. AgNOR positivity increased with the loss of cellular differentiation; a progressive increase in size and a poorly defined shape were evident in poorly differentiated carcinomas. CONCLUSIONS: The results of this multicenter study showed that there is a noticeable difference in the expression of PCNA, p53, cyclin-D1, and AgNOR in tissues from patients with LLSCC and controls.

Aged↗
PubMed2000

Anaerobic sealants: still a problem today.

Acrylic anaerobic sealants are widely used in engineering and electronic industries. They may induce allergic contact dermatitis of the first three fingers and onycholysis. We report a case of allergic contact dermatitis due to anaerobic sealants and we underline some practical problems connected with the frequency of sensitization, patch-testing and material safety data sheet availability.

Acrylates↗
PubMed2000

Vulvar hidradenoma papilliferum. A review of 10.5 years' experience.

OBJECTIVE: To analyze 10.5 years' experience with hidradenoma papilliferum in Ferrara, Italy. STUDY DESIGN: Review of 8 cases plus 25 from other area clinicians. RESULTS AND CONCLUSION: The clinical aspects of hidradenoma papilliferum are confusing. The tumor is uncommon, so physicians do not gain enough experience to recognize it. Histology is diagnostic and simple excision curative.

Adenoma, Sweat Gland↗
PubMed2000

Serious hematoma of the vulva from a bicycle accident. A case report.

BACKGROUND: Vulvar hematomas may be caused by obstetric, athletic or sexual trauma or by car or bicycle accidents. CASE: A 29-year-old woman presented with a serious vulvar hematoma caused by a straddle bicycle accident. Monitoring of the hematologic parameters showed progressive anemia resulting from silent bleeding, which required surgical evacuation of the hematoma and complete hemostasis. CONCLUSION: The rich vulvar vascular network may be easily damaged by contusive frontal impacts, which crush the vulvar tissues against the osseous planes. Management of vulvar hematomas may range from conservative to surgical. Drainage and incision are advised in more severe cases to reduce infective complications and hospitalization.

Adult↗