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Biomedical subjects

A Vighetto

Publications and source records attributed to A Vighetto.

113 records · Page 7Linked to original sources

[Anatomo-clinical study of a case of topographic confabulation (or delusion)].

The authors report an observation of a fixed monothematic and long-termed topographical confabulation associated to a topographical disorientation, without mental confusion. Different factors leading to such a confabulation are discussed (alteration of topographical memory, anosognosia of the ambulatory defect, age of the patient). The favourable effect of neuroleptics permit to regard the continuity between confabulation and delirium. Anatomical data prove an isolated right parieto-temporal infarct.

Aged↗

[Non-hemorrhagic forms of intracranial arterial aneurysms].

Thirty eight consecutive cases of intracranial arterial aneurysms collected during the last decade in the same department of neurology are reported, the aneurysms being revealed by a non hemorrhhagic semeiology, i.e. without clinical meningeal syndrome. In 31 cases, the aneurysm seemed to be related to the clinical manifestation: in 14 cases, it was an acute headache, characterized by its suddenness, immediate maximum intensity, spontaneous and fastly regressive course. It occurred without any symptoms (6 cases) or associated with an epileptic seizure (1 case), or an ophthalmoplegia (7 cases). The course was often relapsing. In 8 cases, it was a cerebrovascular accident of ischemic type; in 6 cases, a pseudo-tumoral syndrome; in 2 cases, an epilepsy; in 1 case, a migraine. For the further 7 cases, the aneurysm was diagnosed fortuitously when investigating a non related disease. The present series shows: the high incidence of the non hemorrhagic forms of aneurysms since they account for 40 p. 100 of the aneurysms cases detected during the same period in our neurological department. The various clinical manifestations are already well-known, mainly the acute headache and the pseudo-tumoral forms. The aneurysm-related cerebrovascular accidents seem to be relatively frequent; 2 cases of the present series give the opportunity for a discussion about the relations between a spontaneous thrombosis and a definitive anatomical cure of the aneurysm. Finally, other cases lead to suspect aneurysms as a possible cause of epilepsy or of migraine. The prognosis of these non hemorragic forms of aneurysms is much better than that of ruptured aneurysms. The direct intracranial surgical cure of the lesion gives on the whole excellent results. Such a treatment must be advocated whenever possible for any unruptured symptomatic aneurysm, as the risk of their rupture or clinical relapse is far from being negligible. The strategy is more difficult to define for asymptomatic unruptured aneurysms as the actual risk of subsequent rupture or other clinical manifestations is not sufficiently known.

Adult↗

[Hemiballismus with logorrhea and thymo-affective disinhibition caused by hematoma of the left subthalamic nucleus].

A 71 year-old hypertensive right-handed man presented a small intracerebral haematoma limited to the left subthalamic nucleus that resulted in right hemiballismus and a neurobehavioral disinhibition syndrome. The latter associated logorrhoea and euphoria, but there was no frontal signs nor mental confusion. The patient kept full insight into his mental change, that contrasted with his prior personality. Hemiballismus and the manic-like state resolved within 2 months. This case and some others from the literature illustrated that a focal lesion in the basal ganglia could result in manic-like affective change, and that a relation did exist between hyperkinetic syndrome and euphoria. Our case contrasted with most of the published cases of neurobevioral changes following basal ganglia discrete lesions, expressing as hypokinesia, apathy and loss of motivation. With reference to the functional circuits linking the frontal cortex and the basal ganglia, as described by Alexander, this syndrome of combined disinhibition of motricity, speech and affect could involve either the lateral orbito-frontal or the anterior cingulate loops, more especially the indirect pathways travelling through the subthalamic nucleus, lesion of which is known to disinhibit thalamo-cortical activity.

Aged↗