Search PubMed⌕ Search

Biomedical subjects

A Verma

Publications and source records attributed to A Verma.

224 records · Page 13Linked to original sources
PubMedDate not supplied

Alterations in the hematological profile in rat following whole body gamma radiation with and without venoruton pretreatment.

The radioprotective effect of venoruton [O-(beta-hydroxyethyl)-rutoside] has been assessed in the hematological profile of Swiss albino male rats subjected to a single dose of 300 rads whole body gamma radiation. The results showed that the severity of the radiation-induced abnormalities in the red and white blood cells is significantly lessened by venoruton administered prior to radiation exposure.

Animals↗
PubMedDate not supplied

Pancreatic islet transplantation: utility of ductular obstruction and exocrine atrophy model?

Introduction of 'silent' exocrine atrophy (and endocrine 'enrichment') in pancreatic grafts following ductular blockade may have a role in human diabetes by circumventing currently elusive islet isolation/purification protocols. To explore this potential, pancreatic isografts were performed in 12 pairs of inbred Wistar NIN rats. Donor pancreatectomy was performed after distal clamping and canulation of common bile duct and injection of 0.5 ml. polyacrylamide gel (blocked n = 7) or normal saline (un-blocked n = 5) respectively. One to 2 m.m. fragments of the resulting mildly distended pancreases were transplanted in to 2 sites (renal capsule and iliac fossa subcutaneously) of cach recipient. Post-operative biopsies of the transplanted grafts (unilateral nephrectomy and iliac fossa biopsies) revealed macroscopic and microscopic evidence of necrotizing pancreatitis in both the groups at both the sites (histiocytic and giant cell infiltration, fat necrosis and focal calcification with destruction of exocrine and endocrine cells) as early as 1 and 3 weeks. Possible detrimental factors include: volume and pressure of ductal injection, graft sites (confined spaces), post-operative wound infection and bio-compatibility of the material used for ductular blockade.

Acrylic Resins↗
PubMedDate not supplied

Differential role of dopamine receptor subtypes in thermoregulation and stereotypic behavior in naive and reserpinized rats.

The present study explores the differential role of dopamine receptor subtypes and their interplay in the thermoregulation and stereotypic behavior in naive and acutely or chronically reserpinized rats. In naive rats, the D2 dopamine agonist B-HT920 (0.25-1 mg/kg) produced hypothermia, an effect sensitive to blockade by the D1/D2 antagonist haloperidol (0.5 mg/kg) and to potentiation by the D1 agonist SKF38393 (5 mg/kg). The hypothermic effect of the same doses of B-HT920 was reduced following acute reserpinization (5 mg/kg, 24 hr prior) but significantly enhanced following chronic reserpinization (1 mg/kg for 15 days), as compared with the B-HT920 effect in naive rats. Although SKF38393 (5 mg/kg) failed to elicit any significant effect on the rectal temperature, it potentiated the hypothermic effect of B-HT920 (0.25 mg/kg) in naive and acutely reserpinized rats. SKF38393 (5 mg/kg), on the contrary, produced a slight hyperthermia and failed to enhance the hypothermic effect of B-HT920 (0.25 mg/kg) following chronic reserpinization. A higher dose of SKF38393 (10 mg/kg), however, produced a significant rise in body temperature when administered alone or in combination with B-HT920 (0.25 mg/kg) in chronically reserpinized rats. Apomorphine (0.25-2 mg/kg), a mixed D1/D2 agonist, also produced a significant hypothermia in naive and acutely reserpinized rats. Following chronic reserpinization, however, apomorphine (0.25-1 mg/kg) produced a significant rise in body temperature, which was significantly enhanced upon co-administration with SKF38393 (5 mg/kg) but reversed to hypothermia when given in combination with B-HT920 (0.5 mg/kg). Similarly, B-HT920 (0.25-1 mg/kg) or apomorphine (0.25-2 mg/kg) produced a mild stereotypy in naive rats. The stereotypic effect of B-HT920 as well as of apomorphine was enhanced in parallel with the increase in the duration of reserpinization. SKF38393 (5 mg/kg) failed to elicit any significant stereotypic effect but significantly enhanced the stereotypic effect of B-HT920 (0.25 mg/kg) in naive or reserpinized rats. The above data, therefore, suggest a differential involvement of D2 and D1 receptors in temperature changes and stereotypy in naive and reserpinized rats, respectively.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗
PubMedDate not supplied

Ultrasonic evaluation of pleural opacities.

Fifty patients of pleural effusion were subjected to radiological and ultrasonic examinations. The results of both examinations were compared and presented here. The study was undertaken to assess the comparative efficacy of ultrasonography in diagnosing pleural effusion.

Adolescent↗
PubMedDate not supplied

Radiation-induced brachial plexopathy: MR and clinical findings.

A 54-year-old man had a slowly progressive bilateral brachial plexopathy 17 months after surgery and radiation therapy for a stage IV supraglottic carcinoma. MR imaging at presentation showed a symmetric pattern of parascalene and interscalene hyperintense signal on T2-weighted images and after contrast enhancement. Although hyperintense signal has been more often associated with recurrent tumor than with delayed radiation injury or fibrosis, the location and pattern of the signal abnormalities suggested a diagnosis of radiation-induced plexopathy. This diagnosis was confirmed by the relative stability of the neurologic and MR findings 30 months after treatment.

Brachial Plexus↗