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Biomedical subjects

A Verdeguer

Publications and source records attributed to A Verdeguer.

42 records · Page 3Linked to original sources
PubMed1983

[Wilms' tumor. Clinico-prognostic correlates].

A series of 42 children with Wilms' tumor collected in 11 years is reported. The female-to-male ratio was 1,5:1 and 85 per cent of the patients were under 5 years at diagnosis. The majority of the tumors were Stage I (38 per cent) followed by Stages III and IV. Pathological findings following Belkwith's criteria are commented upon. The 5 year survival was 72 per cent, and tumor-free survival was 62 per cent. There was a clear relationship between survival and Stage, age and the presence or absence of intra-abdominal lymph-node spread. Efficacity of preoperative chemotherapy and its' influence on the stage of tumor at operation is discussed.

Child↗
PubMed1983

[Malignant histiocytosis in children].

Three cases of malignant hystiocytosis in infants are reported. Two of them are medullary hystiocytic reticulosis and the other one familial erytrophagocytic lymphohystiocytosis. Clinical and pathological differences and similarities between both entities are discussed. Our experience sustains the hypothesis that RHM and LEF are two forms of a same disease.

Age Factors↗
PubMed1982

[Epidemiology of leukemia in children in Valencia (author's transl)].

The incidence of leukemia in Valencia in children zero-seven years old, during a period of ten years (1970-1979), is studied. One hundred and fifty five cases of leukemia were diagnosed on five hospitals during this time. This makes an incidence of 3.5 cases per 100,000 children and years. A light predominance of males was observed and the peak age of presentation was between two and five years. Acute lymphoblastic leukemia was the more frequent variety, followed a big distance by acute myeloid. The relation with other factors, as chromosome abnormalities, parents age, socioeconomic level, are also studied.

Age Factors↗
PubMedDate not supplied

Intrathecal chemotherapy-related myeloencephalopathy in a young child with acute lymphoblastic leukemia.

Since the mid-1960s intrathecal chemotherapy (methotrexate [MTX], cytarabine [Ara-C], or both, plus hydrocortisone) has constituted the standard approach to prophylaxis and treatment of central nervous system (CNS) leukemia and lymphoma. Intrathecal chemotherapy-related neurotoxicity has been described in a variable proportion of patients. At least 35 cases of subacute myeloencephalopathy with transient or permanent paraplegia/quadriplegia after intrathecal chemotherapy have been reported. Different factors have been cited: high cumulative MTX dose, meningeal leukemia, cranial irradiation, and preservatives in MTX and Ara-C. A direct toxic effect of the intrathecal chemotherapy seems the most likely mechanism. Early imaging studies are usually normal. We describe a nonfatal case of permanent flaccid quadriplegia after the fourth triple intrathecal chemotherapy in a 6-year-old girl with acute lymphoblastic leukemia and no evidence of meningeal involvement. Six months after intrathecal chemotherapy, CNS magnetic resonance imaging showed severe atrophy of spine, cerebellum, and cerebral hemispheres. The outcome of reported cases is diverse. No treatment has been shown to reverse neurotoxicity. Among the cases reported in the literature, complete recovery of neurologic deficits was observed in 9 patients, partial recovery with variable sequelae in 6, no recovery in 8, and 13 patients died from the initial oncologic disease or neurotoxicity progression.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Immunosuppression. Role on the infectious diseases of oncologic children.

Cancer patients show an immune deficit whose beginnings are influenced to one extent or another, by two factors: the cancer itself, and the antimitotic-immunosuppressive treatment to which the patient is subjected. The immune deficit will have repercussions in the anti-infectious defense that these patients show: --Greater number of infections. --Greater severity of infections. --Tendency towards generalization and showing of septicemic states. The problem is most serious in hematological tumors (leukemia, lymphosarcoma) where the primary cause of death is infection. During the period of activity of the disease, and also in relation to the antimitotic treatment, the PMN will decrease in absolute count and will function poorly. The consequence will be a high frequency of bacterial infections, sepsis, pneumonia, skin infections, etc., predominantly caused by gram-negative germs and staphylococcus (any germ considered not to be "very virulent" can be found); and it will result in a high mortality rate. When these children are in remission or have solid tumors, the problem is not so acute, and bears more relation to antimitotic treatment and other extraneous factors (hospitalization, catheters, antibiotics, gastrointestinal ulcers...). Patients most frequently show localized bacterial, viral and protozoon infections (varicella, zooster, herpes simplex, cytomegalia, pneumocystis) because of the predominance of cellular immunity deficit.

Antibody Formation↗