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Biomedical subjects

A Valero

Publications and source records attributed to A Valero.

98 records · Page 6Linked to original sources
PubMedDate not supplied

[Occupational hypersensitivity to spiramycin. Report of a case].

A case report of occupational hypersensitivity to Spiramycin. Rhinoconjunctivitis and spasmodic cough are reported in a 34 year-old female handling spiramycin powder in a pharmaceutical factory. The symptoms appeared within the first few hours of coming into contact with the drug and continued for several hours after leaving her place of work. The patient had no personal case history of atopy. Results for prick-test with extracts using a concentration of 1/100 (w/v) were positive, as were results por intradermical tests with a solution using a concentration of 1/10.000 (w/v). The diagnostic was confirmed with the application of a nasal provocation test. Our criteria to determine positivity to this test was according to Bachman (1) and the European Committee of Rhinomanometry. On our suggestion the patient was transferred to another section of the pharmaceutical company whereupon all symptoms disappeared immediately and no further allergic reactions to drugs were registered. This case suggest that reactions to a chemical product may involve immunological mechanisms.

Adult↗
PubMedDate not supplied

[Prolactin variants in serum and amniotic fluid of women with ovulatory hyperprolactinemia].

There is enough evidence that prolactin (PRL), like many other pituitary hormones, is composed by multiple forms that differ from each other by size charge. Although they can be seen in the pituitary glands of a variety of species, their biological significance, identity and chemical nature still remain poorly understood. Recently, a new syndrome characterized by normal ovarian function in the presence of sustained hyperprolactinemia has been reported by our group. In these women, highly abnormal percentages of serum big big PRL have been consistently demonstrated. This observation suggests that big big PRL is immunologically similar, but biologically less active than monomeric or little PRL. In this study we have determined then molecular size heterogeneity of immunoreactive PRL in serum and amniotic fluid from two ovulatory hyperprolactinemic subjects (subjects A and B) who had, under non-pregnant conditions, large amounts of serum big big PRL, throughout different stages of parturition. Control subjects consisted of two women at the end of pregnancy in whom PRL species demonstrated a normal size distribution (subjects C and D). Mean basal levels of PRL were the highest in subjects A and B and remained constant during labor. In the control subjects a remarkable decline in PRL levels was observed during the periparturitional period. This pattern of PRL release was not correlated with changes in steroid hormone concentrations. The relative proportions of PRL size variants throughout delivery showed no apparent changes in all four subjects.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Parameters of immunotherapy: a retrospective study.

This is the second in a series of studies carried out on a group of 26 patients undergoing immunotherapy (IT) (9). The objective of this paper was to determine a new subclass of specific IgG, IgG1, so as to achieve comparable results with the previous study on IgG4. All patients in the study group were suffering from respiratory diseases and were all sensitized to Dermatophagoides pteronyssinus (DPT). They were subjected to IT for a period of 36 months. A 6 monthly control on the levels of anti-DPT specific IgE, anti-DPT specific IgG1 and anti-DPT specific IgG4 was done. Our results showed a level drop in anti-DPT specific IgE after 12 months of immunotherapy (p < 0.001) which was maintained in the 6 monthly controls which followed levels of anti-DPT (p < 0.01). Levels of anti-DPT specific IgG1 (p < 0.05) were lowered following 30 months of IT and were maintained till the end of treatment. The levels of anti-DPT specific IgG4 showed a level increase (p < 0.05) between 6 and 24 months of IT. The anti-DPT specific IgG4 level after 36 months of immunotherapy were lower than those obtained after 24 months of immunotherapy and were of no statistical significance. These values were statistically significant, however, when compared with the levels obtained prior to IT (p < 0.05). The IgG4/IgG1 ratio showed a gradual increase and reached extreme values after 24 months of IT (p < 0.05). There was no relationship between these values and the clinical evolution of each patient.

Adolescent↗
PubMedDate not supplied

Contact dermatitis: clinical review of 800 patients tested using the standard European series.

The results of the use of the European Standard Series on 800 patients suffering from Contact Dermatitis, including occupational Dermatosis is reported. This work also attempts to provide insight into the interests and difficulties of carrying out an epidemiological study in an Allergy Centre and Immunology Clinic. All the patients underwent a Patch Test following the guidelines laid out by the International Contact Dermatitis Research Group. The results of the patch tests were positive in 462 patients (57.7%) and negative in 338 cases (42.3%). The agents responsible for the symptoms in our study were as follows: metals (33%), parafenilen-diamine (13.9%), cobalt (13.3%), perfumes (5.5%), benzocaine (5.4%) and potassium dichromate (5.4%). In this study 72 patients were verified to have Occupational Dermatosis, corresponding mainly to the following occupational sectors: metal industry workers, hairdressers and bakers and pastry makers.

Adolescent↗
PubMedDate not supplied

Exercise-induced asthma prophylaxis in athletes using inhaled nedocromil sodium.

This open labelled, group comparative, cross over study, was carried out to analyze the efficacy of two dosages of Nedocromil sodium (NS) in the prophylaxis of Exercise Induced Asthma (EIA). 13 athletes (6 males, 7 females), aged: 12-38 years, were studied measuring their EIA by forced spirometries prior and at 1, 3, 5, 10, 15 and 30 minutes post treadmill test. Four mg of NS were administered via inhalation chamber 30 minutes prior to the second test; prior to the third one;: NS at a dose of 4 mg every 8 hours during four weeks plus 4 mg of NS 30 minutes before it. In the baseline exercise test, a 33.6 +/- 10.5 percent decrease of FEV1 was observed; 12.6 +/- 11.4 in the second one, and 9.7 +/- 9.76 in the third test. A protection index higher than 30% was obtained in 9 cases of the second test (81.5 +/- 16.2%), and in 10 of the third one (77.2 +/- 15.3%). Nedocromil sodium (4 mg prior to exercise) is effective for EIA prophylaxis. Although no significant differences exist between both dosages, a greater protection index is reached after NS sustained administration.

Adolescent↗