Biomedical subjects
Publications and source records attributed to A Valdazo.
The authors reported a case of cervical paraganglioma. Patient had a coma suggesting secretary activity of the lesion or cerebral venous thrombosis. Angiography showed an hypervascular lesion characterized by venous reflux into the contro-lateral sinus. After neurological stabilization by tumor embolization, the tumor was surgically removed.
On the basis of 6 cases, the authors review the clinical, histological and therapeutic aspects of olfactory esthesioneuromas. These rare tumours, showing varying rates and degrees of progression from one patient to another, generally have a severe prognosis. Diagnosis is based upon precise histological criteria which may be clarified by electromicroscopic data. In difficult cases it may be useful to seek the aid of immuno-histochemical techniques in order to demonstrate the presence in tumour cells of specific neuronal enolase and the labelling of such cells by anti-protein S-100 antibodies. The treatment of choice would appear to be radio-surgical completed by chemotherapy similar to that used in neuroblastomas.
A case report concerning a left primary maxillary meningioma is presented. Clinical, conventional radiographic and CT signs are presented. The diagnosis was made after histologic examination of the specimen. The pathogenesis is discussed.
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An anatomical and neuroradiologic study was conducted to define arterial irrigation of the nasal fossae, the topography of the different vascular territories, particularly that supplied by territories, particularly that supplied by the internal maxillary artery which is by far the most important, and the anastomoses of the different endo- and extra-nasal internal and external carotid systems.
Selective embolization of the distal branches of the internal maxillary artery was performed to treat severe essential epistaxis in 11 patients. Elective indications for this technique are elderly patients with profuse epistaxis.
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Ten cases of vesicular eruption affecting primarily the hands (4/10) and feet (6/10) occurred in a day-nursery for infants. An enterovirus related to coxsackie A 16 virus was isolated from two vesicular fluids and nine stools. The fact that the outbreak took place in the winter, the rarity of pharyngeal lesions (2/10), the high incidence of foot lesions and the presence of listlessness as only associated symptom lead to a discussion of the relationship between this small epidemic and true hand, foot and mouth disease.
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The detection of rubella haemagglutination inhibiting antibody, in the IgM fraction of the serum, on gel filtration through Sephadex G 200, needs precautions to exclude false results. Treatment with dithiothreitol is a satisfactory method for confirming the content of rubella IgM antibody. The failure of MnCl2-heparin pretreatment to remove non specific inhibitors of rubella hemagglutinin is unfrequent (7/108) and so do be repeated. Rarely (1/108) aggregated IgG fractionates with IgM and yield false positive results.
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The eosinophilic granuloma is part of the histiocytosis X classification, having a common histological substratum, the granuloma, which is characterized by a proliferation of histiocytes (reticulo-endothelial cells) and a cytoplasmic inclusion body (the X body) whose étiopathogenic significance is not yet established. These histiocytes are accompanied by other cells and in particular granulocytes, the majority of which are eosinophils. Histiocyte proliferation leads to a destruction of bone which is the organ preferentially affected. At first there is osteolysis (this explains the lacunar aspects seen radiologically) followed by sclerosis. The clinical classification established by Lichtenstein in 1953 outlines the tissue form (eosinophil granuloma), the acute disseminated form (Letterersive) and the chronic disseminated form (Hand-Schüller-Christian). This classification is still accepted today but it needs to be refined to include the transitionary forms, and solitary bone granulomas whose long terme evolutive nature it is impossible to measure clinically, biologically, or histologically. From our observation we note that therapy (surgery, radiotherapy, chemotherapy) is effective in controlling the acute growth spurts in a majority of the cases but does not seem to effect the potential long terme evolution.
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