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Biomedical subjects

A V Vazhenin

Publications and source records attributed to A V Vazhenin.

At least 19 recordsLinked to original sources
PubMed2005

[Arteropathy as late-onset complication of radiotherapy for malignant tumor].

Such late-onset complications of radiotherapy as stenosis and occlusion of major arteries within fields of irradiation, designated in this paper as "post-radiation arteropathy", have not received sufficient scrutiny. The study group of 50 patients (1964-2003) included 35 females and 15 males, aged 33-77, (mean age--59 years). Total focal dose ranged 24-74.8 Gy (mean dose--48.9 Gy) per vascular bunch projection. Signs of ischemia were detected in the catchment area of irradiated artery after 8-360 months (average 90.6 months). Palliative treatment was given to 29 patients while 21 were operated on. Certain morphological features atypical of atherosclerosis were identified. Despite some negative factors, the results were not inferior to those of therapy for atherosclerosis. The hazard of stenotic effect of irradiation of major arteries in area of exposure should be perfectly clear to radiologists, oncologists and vascular surgeons.

Adult↗
PubMed2004

[Therapy of cancer patients with concurrent critical atherosclerosis of the aorta and peripheral arteries].

The results are presented of 5-year experience with therapy of concurrent neoplasia and atherosclerotic lesions of the aorta and peripheral arteries gained at the Center for Oncosurgery, Regional Oncological Dispensary, Chelyabinsk. The analysis was concerned with the treatment received by 118 patients, irrespective of tumor stage or localization: surgical correction of blood flow was carried out in 60. Clinically significant atherosclerotic lesions of the aorta and peripheral arteries in a cancer patient should not be regarded as absolute or relative contraindication for combined treatment. Atherosclerotic occlusion of the femoral or shin arteries was managed conservatively in most cases (p<0.05). In cases of similar lesions of the carotid arteries and aortal aneurysm, surgical correction of blood flow was mostly used.

Aged↗
PubMed2003

[Complications of combined therapy for stomach cancer].

An original classification of complications of combined treatment for gastric cancer is suggested. The results of treatment of 300 cases are evaluated. The qualitative and quantitative characteristics of complications after combined treatment differ from those of surgery alone. They are mostly transient in nature and cannot influence the strategy of therapy, nor do they contribute to a significant rise in mortality rates. According to the present results, no complications should ever justify a refusal to undertake combined treatment.

Combined Modality Therapy↗
PubMed2003

[Metachronous multiple primary tumors of the female genitals. Role of radiotherapy in secondary tumorigenesis].

According to the Center's register, primary multiple tumors were detected in 584 patients (5%) (metachronous--413 (70.7%); synchronous--138 (23.6%) in 1960-1998. In 4.8%, both types were hormonally-dependent; familial cancer was identified in 10.8%. Out of 298 patients treated with radiation, 41 (13.8%) developed tumors in the area of exposure. Excessive dosage due to taking repeat courses for relapse was received by 10 (24.4%). Thirty patients (10.1%) had malignancies outside the exposed area, in distant organs. Such factors as total over dosage due to repeat courses, extensive exposure of the bone marrow and idiosyncrasy to radiotherapy were mainly responsible for secondary tumorigenesis both in and outside zone of exposure.

Female↗
PubMed2003

[Neutron-photon radiotherapy of brain tumors].

The data on combined photon-neutron radiation therapy of brain tumors (23 patients) are presented. Total focal dose (NSD) of photon radiation was 48-60 isoGy; neutron radiation--2.4 Gy (OBE equivalent to gamma radiation of 14.4 Gy). Out of 23 patients, 15 (65.2%) had suffered from tumor disease for a long time which continued after surgery or combined treatment, while 8 (34.8%) were followed up after treatment for primary brain tumor. First symptoms were evaluated. Dehydration therapy was given to 16 (69.6%). Photon- neutron radiation therapy follow-up was up 12 months. Immediate results were assessed every week. The number of complaints went down by approximately 12-15%; improvement was reported in 13 (56.5%), stabilization--9 (39.2%), deterioration--1 (4.8%). According to CT examination of the brain one month later, condition at focal site was unchanged in 17 (73.9%), 10% regression of tumor--6(26.1%). General aggravation of symptoms without roentgenological signs of tumor progression was registered in one case 3 months later. Brain tumor relapsed in still another patient 4 months later. All patients survived 12 months. These indices were 1.5-2 times higher than those for treatment of similar pathology using photon component alone.

Adult↗
PubMed1995

[Use of cava-filter in the treatment of acute venous thrombosis in the end of pregnancy].

Cava-filters were implanted in 16 women suffering from acute thrombosis of the deep veins of the lower limbs in the third gestation trimester. Initial or relapsing thromboembolism of the pulmonary artery (TEPA) had place in 5 cases. Two types of filters were used, the REPTEPA ones being used more frequently. As a rule, a filter was implanted in the infrarenal segment of vena cava inferior. Complications occurred in two patients: perforation of right atrial wall and thrombosis of the filter. Pregnancy ended in delivery in all the cases, cesarean section was made in the majority of patients. No TEPA was recorded from the moment of cava-filter implantation. In remote period 15 women developed moderately expressed postthrombotic syndrome.

Adolescent↗
PubMed1993

Endarterectomy and shunt: alternatives or in tandem?

There is no doubt about the efficacy of endarterectomy in the instance of localized occlusions of the arterial tree. The procedure was first developed in 1946 and has been widely used. However, in the case of extensive, non-localized atheromatus disease of the aorta-iliac and the femoral-popliteal-tibial segments in the leg, the majority of vascular surgeons prefer the application of shunts or prosthetics. Nevertheless, there are proponents of extensive obliteration of the endothelium in these regions. There is also the possibility of combining both techniques. In order to assess the outcomes of the latter technique, we reviewed 567 patients who were operated on for aorta-iliac and for femero-popliteo-tibial disease at Chelyabinsk Centre for Vascular Surgery in Russia from 1987 to 1991. Five hundred forty-one of these suffered from atherosclerosis. The other 26 patients had non-specific inflammation of arterial system. The age distribution was 32 to 78 years; there were 551 men and 16 women. Ischemia in the degree of III to IV (according to the scale established by Fontain) was present in 341 patients. Multi-site occlusions and associated multi-organ disease affected 213 patients. Atheromatous disease was determined by ultrasonography, load tests and angiography.

Adult↗
PubMed1991

[Replacement of infected vascular prosthesis by the femoral vein].

The article discusses restorative treatment of 12 patients with an infected prosthesis in the inguinal region after aortobifemoral, unilateral common iliofemoral, and submusculofemoral shunting. The infected segment of the prosthesis was removed 9 days to 5 weeks after the first operation by cutting it in tissues which were not involved in inflammation. The lacking segment of the shunt was replaced by the patient's femoral vein which was drawn through the infected wound. In 11 patients the wound in the inguinal region healed with maintained patency of the shunt. In 2 patients the extremity was amputated. Marked temporary venous insufficiency was encountered in one case.

Adult↗
PubMed1991

[Multiple-primary cancer of the skin].

Fourteen cases of multifocal squamous cell cancer of the skin are analyzed clinicomorphologically. Such form of skin cancer arises typically on the limbs following long-standing lesions: trophic ulcer, osteomyelitis, psoriasis, lupus. The tumors are both synchronous and metachronous. The prognosis is often unfavorable due to late diagnosis. Multiplicity of the lesions could be attributed to lymphogenic or hematogenic subcutaneous metastases in generalization of the malignant process.

Adult↗
PubMed1991

[Organization of radiotherapy of patients with cancer of the mouth].

During the last 15 years, the incidence of oropharyngeal cancer in the Chelyabinsk region increased from 2.0 to 5.7 per 100,000 of population. Lethality was 2.8 per 100,000. The radiological service of the region includes 4 radiological departments with a total of 270 beds equipped with 7 and units for gamma-ray teletherapy whereas in the oncological dispensary intrathecal gamma-ray therapy can be performed. Under these conditions, it is justified to plan treatment in the regional dispensary and to carry out gamma-ray teletherapy in the radiological department located most closely to the patient's place of residence whereas interstitial therapy should be performed in the dispensary. The said approach assured higher efficacy of treatment, better psychosocial status of patients and shorter duration of therapy; it holds promise for tumors of other sites requiring complex and costly procedures of intrathecal irradiation.

Brachytherapy↗
PubMed1991

[Combined radiation treatment in cancer of the oral cavity organs and the lower lip].

Within 1984-1989, combined radiation treatment was performed in 189 cases of cancer of the oral cavity and lower lip in the Regional Oncological Dispensary, Chelyabinsk. Complete response was achieved in 166 (87.8%) cases whereas 154 (81.5%) remained disease-free for 2 months--5 years. Radiation injury was observed in 27 (14.2%) patients: radiation ulcer--in 18 (9.5%) and osteomyelitis--in 9 (4.7%) cases. Regional metastases were the most frequent cause of death (85%).

Adult↗