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Biomedical subjects

A V Timchenko

Publications and source records attributed to A V Timchenko.

9 recordsLinked to original sources
PubMed2004

[Level of soluble tumor necrosis factor receptor type I in patients with systemic scleroderma].

AIM: To study content and clinical correlations of sTNF-RI in patients with systemic sclerosis (SS). MATERIAL AND METHODS: Thirty nine SS patients were examined with enzyme immunoassay for serum levels of sTNF-RI and soluble adhesion molecules (sSAM) sVSAM-1, sISAM-1 and sR-selectine using R&D System kits (USA). The control group consisted of 14 healthy subjects (donors). Content of sTNF-RI and sSAM was considered as elevated if it exceeded relevant mean values by 1SD. RESULTS: sTNF-RI content was significantly higher in the patients than in the controls (p = 0.0001) and was similar in patients with diffuse and limited forms of the disease. A rise in sTNF-RI correlated with a rise in pulmonary artery pressure. In patients with pulmonary hypertension or restrictive pulmonary affection sTNF-RI was higher than in patients free of pulmonary hypertension or impaired external respiration function. A marked correlation was found between sTNF-RI and sVSAM-1. Patients with high CRP had significantly higher sTNF-RI level than patients with normal CRP. CONCLUSION: SS is characterized by elevated content of sTNF-RI. This content may serve a diagnostic marker of the disease progression.

Adult↗
PubMed2003

[Clinical value of soluble adhesion molecules in systemic scleroderma].

The aim of the trial was to study clinical significance of estimation of cell adhesion soluble molecules (CASM) in scleroderma systematica (SS). Quantitation of CASM VCAM-1, ICAM-1 and R-selectin was made with enzyme-immunoassay (R&D System kits, USA) in 38 patients with SS (11 with limited SS and 27 with diffuse SS). The levels of VCAM-1, ICAM-1 and R-selectin was elevated in 30 (79%), 17 (45%) and 20 (53%) patients, respectively. Mean values of VCAM-1 and ICAM-1 in patients were significantly higher than in healthy donors. R-selectin was also higher but insignificantly. A mean CASM level and a relative number of patients with elevated count of CASM in patients with diffuse and limited forms of SS did not differ. In 15 patients with active (progressive) course of the disease the level of VCAM-1 was significantly higher than in patients with chronic (non-progressive) course of SS while concentrations of ICAM-1 and R-selectine were almost the same. Thus, SS patients have elevated levels of CASM. CASM VCAM-1 concentration is the most sensitive marker of SS activity compared to other CASM.

Adult↗
PubMed2003

[Tumor necrosis factor alpha in systemic scleroderma].

The authors present the review of the literature on the role of tumor necrosis factor alpha (TNF alpha) in scleroderma systematica (SS). It is shown that TNF alpha participates in activation of vascular endothelium, regulation of immune response and metabolism of the connective tissue by modulation of fibroblastic function. SS patients exhibit a systemic and local rise of TNF alpha content. This rise contributes to SS progression, development of fibrosing alveolitis and skin fibrous alterations in Raynaud's syndrome.

Disease Progression↗
PubMed1997

[Gastric and small intestine motility in patients with duodenal ulcer and sleep disorders].

Fasting motility of the stomach and small intestine and that after carbohydrate, protein and fat meals were studied with tubes furnished with tensometers over 24-50 hours in 7 healthy and 31 duodenal ulcer males. Over the first night 7 healthy and 17 ulcer subjects were subjected to polygraphic sleep registration including electroencephalogram. Sleep quality was assessed by means of biorhythmologic questionnaire. Time co-incidence was registered for the most active phases of 90-min rhythms of the sleep and periodic gastrointestinal activity. In patients with poor sleep the pattern of periodic motility cycles was abnormal, motility of the jejunal proximal part was inhibited in some time intervals after carbohydrate and protein meals. All the patients with ulcer and sleep disorders received recommendations to take therapeutic measures for sleep normalization.

Adolescent↗